Optical antipodes d-and l-n-benzoyl-3,4-dihydroxyphenylalanine and a process for their preparation
    2.
    发明授权
    Optical antipodes d-and l-n-benzoyl-3,4-dihydroxyphenylalanine and a process for their preparation 失效
    光学抗体D-和L-N-苯甲酰基-3,4-二羟基苯甲酰胺及其制备方法

    公开(公告)号:US3794655A

    公开(公告)日:1974-02-26

    申请号:US3794655D

    申请日:1970-12-18

    CPC classification number: C07D453/04

    Abstract: OPTICAL ANTIPODES D- AND L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE OF THE FORMULA:

    1-(PHENYL-CO-NH-CH(-COOH)-CH2-),3,4-DI(HO-)BENZENE

    AND THE CINCHONNE SALTS THEREOF. THESE COMPOUNDS ARE MADE BY REACTING CHINCHONINE WITH D- AND OR L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE AND THEN CRYSTALLIZING THE SALT FROM MIXTURES OF WATER WITH LOWER KETONES,LOWER ALKANOLS LOWER ETHERS OR MIXTAURES THEREOF IN ORDER TO SEPARATE AND RESOLVE THE OPTICAL ISOMERS. THESE SALTS ARE CLEAVED TO THE OPTICALLY PURE- OR L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE WHICH IS ITSELF CLEAVED TO 3,4-DIHYDROXYPHENYLALANIME.

    Process for the manufacture of pure l-n-benzoyl-3,4-dihydroxyphenylalanine
    3.
    发明授权
    Process for the manufacture of pure l-n-benzoyl-3,4-dihydroxyphenylalanine 失效
    纯L-N-苯甲酰基-3,4-二羟基苯乙胺的制备方法

    公开(公告)号:US3796750A

    公开(公告)日:1974-03-12

    申请号:US3796750D

    申请日:1970-12-18

    CPC classification number: C07C51/487

    Abstract: PROCESS FOR PRODUCING L-N-BENZOYL-3,4-DHYDROXYPHENYLALANINE BY RESOLVING A MIXED DL-N-BENZOYL-3,4-DIDHYDROXYPHENYL-ALANINE; RECOVERING THE L-ISOMER; REACTING THE D-ISOMER WITH ACETIC ANHYDRIDE; PRECIPITATING THE ACETOXY DERIVATIVE THUS FORMED; HUDROLYZING THE ACRTOXY DERIVATIVE WITH ALKALI METAL TO FORM RACEMIC DL-N-BENZOLY-3,4-DIHYDROXYPHENYLALANINE; RESOLVING THE RACEMATE; RECOVERING THE LISOMER; AND RECYCLING THE D-ISOMER.

Patent Agency Ranking