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公开(公告)号:US20150209485A1
公开(公告)日:2015-07-30
申请号:US14677741
申请日:2015-04-02
申请人: Dadong ZHANG , Xu CAI , Chengyun YUE , Junfei LI , Yan HU , Peng HUANG , Zhirong TANG , Qiyi LUO
发明人: Dadong ZHANG , Xu CAI , Chengyun YUE , Junfei LI , Yan HU , Peng HUANG , Zhirong TANG , Qiyi LUO
CPC分类号: A61L31/10 , A61F2/82 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2420/02 , C08L75/04 , C08L67/04 , C08L89/00 , C08L33/10 , C08L5/08
摘要: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.
摘要翻译: 介入医疗装置及其制造方法。 介入医疗装置包括:支架主体(1); 支架体(1)的表面设有药物释放结构(3),药物释放结构(3)中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物 肌肉细胞。 在使用中,将介入医疗装置植入人体后,用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张,并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物 可以抑制血管的内膜增殖。 两种药物的组合大大降低了支架内再狭窄的发生率。