公开(公告)号：US20200246797A1

公开(公告)日：2020-08-06

申请号：US16827448

申请日：2020-03-23

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Min Seok KIM

IPC: B01L3/00 ,  B01D21/26 ,  B01D21/00 ,  B03C1/01 ,  B03C1/28 ,  B03C1/30

Abstract: Provided are a microfluidic apparatus and a method for separating a target cell using the same. The microfluidic apparatus for separating a first material in a biological sample from the biological sample, according to an embodiment of the disclosure, includes: a body rotatable on a rotation axis; a mixing chamber included in the body, wherein the biological sample and magnetic beads that are combined with a second material in the biological sample are mixed in the mixing chamber; a separation chamber included in the body and connected to the mixing chamber, wherein a mixed sample of the first material and the second material combined with the magnetic beads is separated in the separation chamber; and a magnetic member positioned on one side of the body outside the separation chamber, wherein, in the separation chamber, the first material is separated from the second material combined with the magnetic beads by a centrifugal force and a magnetic force.

公开(公告)号：US20230279325A1

公开(公告)日：2023-09-07

申请号：US18019854

申请日：2021-04-27

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min Seok KIM ,  Hyun Gyu KANG ,  Woon Hae KIM

IPC: C12M3/06 ,  C12M1/42

CPC classification number: C12M23/16 ,  C12M1/42 ,  C12M35/02

Abstract: The present invention relates to an electroceutical screening device and a screening method using same, respectively, wherein an electrical stimulation is applied, through the electrodes, to the cell clusters received in the channels, and the potentials of the cell clusters are measured so as to measure neural activity, and thus electrical stimulation tests are conducted in various ways, and by measuring conduction velocity according to the various electrical stimulation tests, conditions for electrical stimulation therapy are assessed.

公开(公告)号：US20210302284A1

公开(公告)日：2021-09-30

申请号：US17207890

申请日：2021-03-22

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min Seok KIM

IPC: G01N1/30 ,  G01N1/31 ,  C12N11/087

Abstract: The present disclosure relates to a method and apparatus for cell staining without cell loss, and more particularly, to a method and apparatus for cell staining without cell loss during treatment of a staining reagent or washing reagent by immobilizing cells to be analyzed in a phase change material before staining. A method for cell staining without cell loss according to the present disclosure may effectively prevent cell loss during staining and analysis of rare cells that are becoming important in clinical diagnosis, and thus may facilitate observation, analysis and diagnosis thereby even with a trace amount of sample. In addition, as the method for cell staining without cell loss according to the present disclosure allows immobilization of cells, it makes discrimination and isolation of single cells easy, and may be effectively used in analysis of the isolated cells.

公开(公告)号：US20210206821A1

公开(公告)日：2021-07-08

申请号：US17059513

申请日：2019-06-24

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Kyung Moo YEA ,  Min Seok KIM

IPC: C07K14/52 ,  C07K14/705 ,  C12N15/86

Abstract: The present invention relates to a cytokine fusion polypeptide or a cytokine library comprising the same, and according to the cytokine fusion polypeptide or a cytokine library comprising the same according to an aspect, it enables continuous stimulation by a cytokine to a target cell and thus can easily and accurately evaluate the functionality of cytokines at the single cell level.

公开(公告)号：US20220143088A1

公开(公告)日：2022-05-12

申请号：US17439124

申请日：2020-03-13

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min Seok KIM ,  Kyung Moo YEA ,  Hyun Young SHIN

IPC: A61K35/17 ,  C12N5/0783 ,  C07K14/55

Abstract: The present invention relates to cytokine-based immune cells and an immunotherapeutic use thereof, and an immune cell according to an aspect is designed in such a form that a cytokine is linked to the surface of the cell via a linker, and thus the cytokine continuously stimulates the immune cell, thereby inducing proliferation and activation, and the cytokine does not affect surrounding cells, whereby side effects can be minimized.

公开(公告)号：US20220032040A1

公开(公告)日：2022-02-03

申请号：US17390156

申请日：2021-07-30

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Min Seok KIM ,  Min Young KIM ,  Hyun Young SHIN

IPC: A61N1/04 ,  A61N1/36

Abstract: A customized electrical stimulation providing system includes: an electrical stimulation request input unit receiving electrical stimulation mode selection information; an electrical stimulation control unit setting an electrical stimulation control variable according to the electrical stimulation mode selection information and generating a control signal; and an electrical stimulation providing means receiving the control signal generated by the electrical stimulation control unit and providing electrical stimulation, wherein the electrical stimulation mode selection information includes at least one of a beauty mode (muscle loss mode) and a muscle strengthening mode.