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公开(公告)号：US20210332149A1
公开(公告)日：2021-10-28
申请号：US17366820
申请日：2021-07-02
发明人： Kensuke Miyake , Yusuke Murakami , Yuji Motoi , Atsuo Kanno , Toshiyuki Shimizu , Umeharu Ohto , Takaichi Shimozato , Atsushi Manno , Takashi Kagari , Jun Ishiguro , Kensuke Nakamura , Takashi Isobe
IPC分类号： C07K16/28
摘要： The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
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公开(公告)号：US10851162B2
公开(公告)日：2020-12-01
申请号：US16460632
申请日：2019-07-02
发明人： Tomoaki Komai , Takako Kimura , Daichi Baba , Yoshikuni Onodera , Kento Tanaka , Takashi Kagari , Anri Aki , Nobumi Nagaoka
摘要： It is intended to provide a therapeutic and/or prophylactic agent for transplant rejections, immunological diseases, allergic diseases, inflammatory diseases, thrombosis, cancers, etc., targeting human Orai1. The present invention provides, for example, a pharmaceutical composition comprising an antibody that specifically recognizes human Orai1 and has the activity of inhibiting human T cell activation.
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公开(公告)号：US10351624B2
公开(公告)日：2019-07-16
申请号：US15502088
申请日：2015-08-06
发明人： Tomoaki Komai , Takako Kimura , Daichi Baba , Yoshikuni Onodera , Kento Tanaka , Takashi Kagari , Anri Aki , Nobumi Nagaoka
摘要： It is intended to provide a therapeutic and/or prophylactic agent for transplant rejections, immunological diseases, allergic diseases, inflammatory diseases, thrombosis, cancers, etc., targeting human Orai1. The present invention provides, for example, a pharmaceutical composition comprising an antibody that specifically recognizes human Orai1 and has the activity of inhibiting human T cell activation.
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公开(公告)号：US20170226203A1
公开(公告)日：2017-08-10
申请号：US15502088
申请日：2015-08-06
发明人： Tomoaki Komai , Takako Kimura , Daichi Baba , Yoshikuni Onodera , Kento Tanaka , Takashi Kagari , Anri Aki , Nobumi Nagaoka
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K16/46 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N15/09
摘要： It is intended to provide a therapeutic and/or prophylactic agent for transplant rejections, immunological diseases, allergic diseases, inflammatory diseases, thrombosis, cancers, etc., targeting human Orai1. The present invention provides, for example, a pharmaceutical composition comprising an antibody that specifically recognizes human Orai1 and has the activity of inhibiting human T cell activation.
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公开(公告)号：US11578138B2
公开(公告)日：2023-02-14
申请号：US17366820
申请日：2021-07-02
发明人： Kensuke Miyake , Yusuke Murakami , Yuji Motoi , Atsuo Kanno , Toshiyuki Shimizu , Umeharu Ohto , Takaichi Shimozato , Atsushi Manno , Takashi Kagari , Jun Ishiguro , Kensuke Nakamura , Takashi Isobe
IPC分类号： C07K16/28
摘要： The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
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公开(公告)号：US11091560B2
公开(公告)日：2021-08-17
申请号：US17069760
申请日：2020-10-13
发明人： Kensuke Miyake , Yusuke Murakami , Yuji Motoi , Atsuo Kanno , Toshiyuki Shimizu , Umeharu Ohto , Takaichi Shimozato , Atsushi Manno , Takashi Kagari , Jun Ishiguro , Kensuke Nakamura , Takashi Isobe
IPC分类号： C07K16/28 , A61K39/395
摘要： The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
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公开(公告)号：US20210040225A1
公开(公告)日：2021-02-11
申请号：US17069760
申请日：2020-10-13
发明人： Kensuke Miyake , Yusuke Murakami , Yuji Motoi , Atsuo Kanno , Toshiyuki Shimizu , Umeharu Ohto , Takaichi Shimozato , Atsushi Manno , Takashi Kagari , Jun Ishiguro , Kensuke Nakamura , Takashi Isobe
IPC分类号： C07K16/28
摘要： The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
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公开(公告)号：US20190322740A1
公开(公告)日：2019-10-24
申请号：US16460632
申请日：2019-07-02
发明人： Tomoaki Komai , Takako Kimura , Daichi Baba , Yoshikuni Onodera , Kento Tanaka , Takashi Kagari , Anri Aki , Nobumi Nagaoka
摘要： It is intended to provide a therapeutic and/or prophylactic agent for transplant rejections, immunological diseases, allergic diseases, inflammatory diseases, thrombosis, cancers, etc., targeting human Orai1. The present invention provides, for example, a pharmaceutical composition comprising an antibody that specifically recognizes human Orai1 and has the activity of inhibiting human T cell activation.
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