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公开(公告)号：US20110218328A1
公开(公告)日：2011-09-08
申请号：US13032412
申请日：2011-02-22
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号：US20120189624A1
公开(公告)日：2012-07-26
申请号：US13314160
申请日：2011-12-07
IPC分类号： A61K39/395 , A61P25/00 , A61P9/00 , A61P43/00 , A61P29/00 , A61P19/02 , A61P35/00 , A61P25/02 , A61P7/00
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号：US20120321555A1
公开(公告)日：2012-12-20
申请号：US13460622
申请日：2012-04-30
CPC分类号： A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号：US07928203B2
公开(公告)日：2011-04-19
申请号：US12345650
申请日：2008-12-29
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20120039878A1
公开(公告)日：2012-02-16
申请号：US13187093
申请日：2011-07-20
IPC分类号： A61K39/395 , C07K16/00 , C12N5/10
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20110224408A1
公开(公告)日：2011-09-15
申请号：US13032507
申请日：2011-02-22
IPC分类号： C07K16/18
CPC分类号： A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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公开(公告)号：US08791243B2
公开(公告)日：2014-07-29
申请号：US12811049
申请日：2008-12-29
申请人： Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
发明人： Dale B. Schenk , Peter A. Seubert , Jonathan Wall , Jose Saldanha
IPC分类号： C07K16/18 , A61K39/395 , C12N5/07
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20140134103A1
公开(公告)日：2014-05-15
申请号：US14099692
申请日：2013-12-06
申请人： Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José Saldanha
发明人： Dale B. SCHENK , Peter A. Seubert , Jonathan Wall , José Saldanha
CPC分类号： A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US08636981B2
公开(公告)日：2014-01-28
申请号：US13314160
申请日：2011-12-07
申请人： Dale B. Schenk , Peter A. Seubert , Jonathan Wall
发明人： Dale B. Schenk , Peter A. Seubert , Jonathan Wall
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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公开(公告)号：US20090202432A1
公开(公告)日：2009-08-13
申请号：US12345650
申请日：2008-12-29
IPC分类号： A61K51/00 , C07K16/18 , A61K39/395 , A61K49/00 , A61K39/00
CPC分类号： C07K16/18 , A61K39/0008 , A61K49/00 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y10S530/809
摘要： Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
摘要翻译： 通过施用包含新表皮的肽，例如来自AA的C末端区域的AA片段和对聚集的淀粉样蛋白的新表皮特异的抗体，例如抗体，可用于预防或治疗淀粉样变性（包括AA淀粉样变性和AL淀粉样变性）的方法 特异于AA原纤维的C-末端区域。 用于抑制形成和/或增加患者淀粉样沉积物清除率的抗体，从而实现预防或治疗淀粉样蛋白病。
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