公开(公告)号：US20090019877A1

公开(公告)日：2009-01-22

申请号：US12087695

申请日：2007-01-16

申请人： Dale Larson ,  Jeffrey Ruberti ,  John Slusarz ,  Nicholas Goulas ,  Erin Rush ,  Trevor Ehret

发明人： Dale Larson ,  Jeffrey Ruberti ,  John Slusarz ,  Nicholas Goulas ,  Erin Rush ,  Trevor Ehret

IPC分类号： F25C5/00

CPC分类号： A01N1/0252 ,  A01N1/02 ,  A01N1/0242 ,  F25D31/00 ,  G01N1/08 ,  G01N1/42 ,  G01N2001/368

摘要： A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software.

摘要翻译： 提供了一种包括产生声音线性振荡运动的电动机的钻井系统，用于从存储的冷冻样品中除去冷冻的生物样品及其使用方法，而不融化样品的其余部分。 定子和滑块组件由伺服控制器操作，该伺服控制器可以通过装有软件的PC的端口进行通信和编程。

公开(公告)号：US08448456B2

公开(公告)日：2013-05-28

申请号：US12087695

申请日：2007-01-16

申请人： Dale Larson ,  Jeffrey Ruberti ,  John Slusarz ,  Nicholas Goulas ,  Erin Rush ,  Trevor Ehret

发明人： Dale Larson ,  Jeffrey Ruberti ,  John Slusarz ,  Nicholas Goulas ,  Erin Rush ,  Trevor Ehret

IPC分类号： F25D25/00

CPC分类号： A01N1/0252 ,  A01N1/02 ,  A01N1/0242 ,  F25D31/00 ,  G01N1/08 ,  G01N1/42 ,  G01N2001/368

摘要： A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software.

摘要翻译： 提供了一种包括产生声音线性振荡运动的电动机的钻井系统，用于从存储的冷冻样品中除去冷冻的生物样品及其使用方法，而不融化样品的其余部分。 定子和滑块组件由伺服控制器操作，该伺服控制器可以通过装有软件的PC的端口进行通信和编程。

公开(公告)号：US20140335554A1

公开(公告)日：2014-11-13

申请号：US13991103

申请日：2011-11-17

申请人： Dale N. Larson ,  Stephen L. Bellio ,  John Slusarz

发明人： Dale N. Larson ,  Stephen L. Bellio ,  John Slusarz

IPC分类号： G01N1/08 ,  G01N33/487

CPC分类号： G01N1/08 ,  G01N1/286 ,  G01N1/42 ,  G01N33/487

摘要： A method of obtaining an aliquot of a frozen sample contained in a container includes moving a coring device into the sample and then withdrawing it to obtain a frozen sample core. The location from which the core is taken is selected to be at a radial position where the concentration of at least one substance of interest in the frozen sample core is representative of the overall concentration of that substance in the sample notwithstanding any concentration gradients that may exist in the frozen sample. Another method includes taking two different frozen sample cores from the same sample from radial positions selected such that the concentration of one or more substances of interest in the combined sample cores is representative of the overall concentration of said at least one substance in the sample notwithstanding any radial concentration gradients. A robotic system is programmed or hardwired to implement the methods.

摘要翻译： 获得包含在容器中的冷冻样品的等分试样的方法包括将取芯装置移动到样品中，然后取出，以获得冷冻样品芯。 选择芯的位置选择在径向位置，其中冷冻样品核心中至少一种目标物质的浓度代表该样品中该物质的总浓度，尽管可能存在任何浓度梯度 在冷冻样品中。 另一种方法包括从所选择的径向位置取两个来自相同样品的不同冷冻样品核心，使得组合样品核心中一种或多种感兴趣的物质的浓度代表样品中所述至少一种物质的总浓度，尽管任何 径向浓度梯度。 机器人系统被编程或硬连线以实现这些方法。