公开(公告)号：US20240361217A1

公开(公告)日：2024-10-31

申请号：US18770727

申请日：2024-07-12

申请人： Phaim Pharma Ltd.

发明人： Tihamer ORBAN ,  Jalahej HEYMAN ,  Nara DAUBENEY ,  Piers DAUBENEY

IPC分类号： G01N1/40 ,  A61K35/17 ,  A61P17/06 ,  A61P37/06 ,  C12N5/0783 ,  C12Q1/02 ,  G01N1/06 ,  G01N1/28 ,  G01N1/36 ,  G01N1/42 ,  G01N33/50

CPC分类号： G01N1/4077 ,  A61K35/17 ,  A61P17/06 ,  A61P37/06 ,  C12N5/0636 ,  C12Q1/02 ,  G01N1/06 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/36 ,  G01N1/42 ,  G01N33/505 ,  G01N33/5091 ,  G01N2001/2873 ,  G01N2800/24 ,  G01N2800/56

摘要： Provided are methods of preparing an immune cell sample from a subject having an autoimmune disorder, the method comprising: obtaining a tissue sample from the subject; and isolating a single immune cell in situ from the tissue sample using laser capture microdissection.

公开(公告)号：US20240344940A1

公开(公告)日：2024-10-17

申请号：US18596485

申请日：2024-03-05

申请人： Rotaprep, Inc.

发明人： Horacio Kido

IPC分类号： G01N1/28 ,  B01F31/20 ,  B01F31/22 ,  B01F33/25 ,  B01F33/501 ,  B02C17/00 ,  B02C17/14 ,  B02C17/24

CPC分类号： G01N1/286 ,  B01F31/201 ,  B01F31/22 ,  B01F33/251 ,  B01F33/50115 ,  B02C17/00 ,  B02C17/14 ,  B02C17/24 ,  G01N2001/2866 ,  Y10T29/49826

摘要： The disclosure is directed to a sample preparation apparatus for grinding or homogenizing test samples. More specifically, the disclosure relates to grinding samples using rotational and linear motion. Grinding samples can be accomplished with an apparatus with a slider-crank mechanism that is attached to an oscillating connecting linkage. The amplitude of oscillatory motion can be greater than or equal to a length of a sample processing chamber.

公开(公告)号：US20240331179A1

公开(公告)日：2024-10-03

申请号：US18736705

申请日：2024-06-07

申请人： Carl Zeiss SMT GmbH

发明人： Dmitry Klochkov ,  Eugen Foca ,  Jens Timo Neumann ,  Thomas Korb ,  Alex Buxbaum ,  Amir Avishai ,  Chuong Huynh

IPC分类号： G06T7/55 ,  G01N1/28 ,  G01N23/203 ,  G01N23/2206 ,  G06T7/00 ,  G06T7/521

CPC分类号： G06T7/55 ,  G01N1/286 ,  G01N23/203 ,  G01N23/2206 ,  G06T7/0004 ,  G06T7/521 ,  G01N2001/2873 ,  G01N2223/401 ,  G01N2223/6116 ,  G06T2200/04 ,  G06T2207/10056 ,  G06T2207/30148

摘要： A system and a method for volume inspection of semiconductor wafers are configured for milling and imaging of reduced number or areas of appropriate cross-sections surfaces in an inspection volume and determining inspection parameters of the 3D objects from the cross-section surface images. The system and method can be utilized for quantitative metrology, defect detection, process monitoring, defect review, and inspection of integrated circuits within semiconductor wafers.

公开(公告)号：US12085522B2

公开(公告)日：2024-09-10

申请号：US17648304

申请日：2022-01-19

申请人： CHANGXIN MEMORY TECHNOLOGIES, INC.

发明人： Kuojung Chiu

IPC分类号： G01N23/2251 ,  G01N1/28

CPC分类号： G01N23/2251 ,  G01N1/286 ,  G01N2001/2873 ,  G01N2223/309

摘要： The present disclosure provides a sample rotation system and method. The sample rotation system includes a rotation device, and the rotation device includes: a first carrier connected to a sample; a drive portion connected to the first carrier, wherein the drive portion is configured to drive the first carrier to rotate; and the first carrier drives the sample to rotate from an initial position to a target position; an acquisition device, configured to acquire a rotation state of the sample; and a control unit, electrically connected to the drive portion, and configured to control operation of the drive portion.

公开(公告)号：US20240288344A1

公开(公告)日：2024-08-29

申请号：US18574341

申请日：2022-06-28

申请人： Teknologian tutkimuskeskus VTT Oy

发明人： Jouni Hokkinen ,  Teemu Kärkelä ,  Anumaija Leskinen

IPC分类号： G01N1/28 ,  G01N1/10 ,  G01N1/22 ,  G01N1/40 ,  G21F9/30

CPC分类号： G01N1/286 ,  G01N1/10 ,  G01N1/2211 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/1018 ,  G01N2001/2866 ,  G21F9/30

摘要： According to an example aspect of the present invention, there is provided a method for sampling a solid object, the method comprising: providing a solid object; treating the solid object mechanically to remove material, such as pulverized material, from the solid object; and aspirating the removed material through a solids separation system, thereby separating one or more solid fractions from said material.

公开(公告)号：US20240280446A1

公开(公告)日：2024-08-22

申请号：US18623376

申请日：2024-04-01

申请人： Singular Genomics Systems, Inc.

发明人： Yuji Ishitsuka ,  Zhenmin Hong ,  Eli N. Glezer ,  Hu Cang ,  William Dempsey ,  Weiqiao Ding ,  Jaekyung Koh ,  Mohammad Vatankhah Varnosfaderani

IPC分类号： G01N1/31 ,  G01N1/28

CPC分类号： G01N1/312 ,  G01N1/286 ,  G01N2001/2873 ,  G01N2001/315

摘要： Disclosed herein, inter alia, are devices and methods for transfer and analyses of tissue sections using carrier substrates.

公开(公告)号：US20240255393A1

公开(公告)日：2024-08-01

申请号：US18587382

申请日：2024-02-26

申请人： Lee H. Angros

发明人： Lee H. Angros

IPC分类号： G01N1/28 ,  G01N1/30 ,  G01N1/31 ,  G01N1/36 ,  G01N1/44

CPC分类号： G01N1/286 ,  G01N1/30 ,  G01N1/312 ,  G01N1/36 ,  G01N1/44

摘要： A method of removing a floatation liquid from between a microscope slide and a paraffin embedded biological specimen including position the microscope slide with the paraffin embedded biological specimen floated thereon onto a slide support element. The slide support element is rotated to cause the microscope slide and the paraffin embedded biological specimen to move in a way that causes the floatation liquid disposed between the microscope slide and the paraffin embedded biological specimen to be removed from between the microscope slide and the paraffin embedded biological specimen.

公开(公告)号：US12050312B2

公开(公告)日：2024-07-30

申请号：US16920158

申请日：2020-07-02

申请人： MMI AG

发明人： Peter Tschanz

IPC分类号： G02B21/32 ,  G01N1/28

CPC分类号： G02B21/32 ,  G01N1/286

摘要： A manipulation system for microscope applications comprises a micromanipulation tool and a protective device protecting the tool, wherein the tool and the protective device are movable relative to one another between a position protecting the tool in a contactless manner and a position releasing the tool for the manipulation.

公开(公告)号：US20240241075A1

公开(公告)日：2024-07-18

申请号：US18434795

申请日：2024-02-06

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang

IPC分类号： G01N27/403 ,  B01L3/00 ,  G01N1/28 ,  G01N1/38 ,  G01N21/84 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00

CPC分类号： G01N27/403 ,  B01L3/502761 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/38 ,  G01N21/8483 ,  G01N33/4905 ,  G01N33/5438 ,  G01N35/00 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415

摘要： Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.

公开(公告)号：US12038357B2

公开(公告)日：2024-07-16

申请号：US17667580

申请日：2022-02-09

申请人： LEICA MICROSYSTEMS CMS GMBH

发明人： Falk Schlaudraff ,  Florian Hoffmann ,  Christoph Greb

IPC分类号： G01N1/04 ,  G01N1/28 ,  G06N20/00 ,  G02B21/06 ,  G02B21/26

CPC分类号： G01N1/286 ,  G06N20/00 ,  G01N2001/045 ,  G01N2001/2886 ,  G02B21/06 ,  G02B21/26

摘要： A method for obtaining dissectates from a microscopic sample using a laser microdissection system having a laser unit includes: a) at least partially circumcising and releasing from the sample dissectate regions of the sample as the dissectates using laser pulses provided by the laser unit; b) transferring the dissectates, by being released from the sample, along dissectate trajectories into receptacles of a dissectate collection unit; and c) positioning the receptacles of a dissectate collection unit using a positioning unit to collect the dissectates. The positioning of the receptacles of the dissectate collection unit using the positioning unit is automatically performed based on estimates of the dissectate trajectories, the estimates of the dissectate trajectories being obtained in a learning mode, the learning mode including obtaining dissectates by repeatedly performing at least steps a) and b). Parameters of the dissectate trajectories are determined for a plurality of dissectates.