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1.发明授权Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效烷基取代的哌啶衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07547788B2
公开(公告)日：2009-06-16
申请号：US11579060
申请日：2005-06-14
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
IPC分类号： C07D211/06 , C07D211/40 , A61K31/445
CPC分类号： C07D211/42 , C07D211/46 , C07D211/54 , C07D211/58
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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2.发明授权Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权烷基取代的哌啶衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07915419B2
公开(公告)日：2011-03-29
申请号：US12437233
申请日：2009-05-07
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
IPC分类号： C07D211/08 , C07D211/40 , C07D211/06 , A61K31/445
CPC分类号： C07D211/42 , C07D211/46 , C07D211/54 , C07D211/58
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2011/02/15/US07888358B2/abs.jpg.150x150.jpg)
3.发明授权8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07888358B2
公开(公告)日：2011-02-15
申请号：US12216213
申请日：2008-07-01
申请人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A61K31/46 , A61K31/498 , A61P25/00 , C07D451/00
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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4.发明授权Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07696350B2
公开(公告)日：2010-04-13
申请号：US11661966
申请日：2005-09-28
IPC分类号： C07D221/02 , C07D225/00 , C07D401/00
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2009/04/28/US07524958B2/abs.jpg.150x150.jpg)
5.发明授权Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效某些9-氮杂 - 双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07524958B2
公开(公告)日：2009-04-28
申请号：US11579056
申请日：2005-06-14
IPC分类号： C07D221/02 , A61K31/44
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2008/08/05/US07407970B2/abs.jpg.150x150.jpg)
6.发明授权8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07407970B2
公开(公告)日：2008-08-05
申请号：US10561417
申请日：2004-06-18
申请人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A01N43/42 , A61K31/44 , C07D451/00 , C07D451/02
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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7.发明授权8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环（3.2.1）辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07247643B2
公开(公告)日：2007-07-24
申请号：US10544027
申请日：2004-02-10
IPC分类号： A01N43/42 , A61K31/44 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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8.发明授权Substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors 失效取代的芳氧基烷基胺及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07973082B2
公开(公告)日：2011-07-05
申请号：US11658902
申请日：2005-08-24
申请人： Birgitte L. Eriksen , Dan Peters , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Birgitte L. Eriksen , Dan Peters , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A61K31/135 , C07C11/00
CPC分类号： C07C217/44 , C07C217/46 , C07C2601/02
摘要： This invention relates to novel substituted aryloxy alkylamines useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型取代的芳氧基烷基胺。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors](/abs-image/US/2010/05/11/US07713990B2/abs.jpg.150x150.jpg)
9.发明授权3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors 失效3,8-取代的8-AZA-双环[3.2.1]辛烷衍生物及其作为单神经递质再摄取抑制剂的用途公开(公告)号：US07713990B2
公开(公告)日：2010-05-11
申请号：US11794365
申请日：2006-01-11
申请人： Dan Peters , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , John Paul Redrobe
发明人： Dan Peters , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , John Paul Redrobe
IPC分类号： A61K31/439 , C07D221/22
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US06617459B2
公开(公告)日：2003-09-09
申请号：US09855630
申请日：2001-05-15
IPC分类号： C07D45104
CPC分类号： C07D451/14 , A61K51/0455 , C07D451/02
摘要： The present invention relates to 8-azabicyclo[3.2.1]oct-2-ene derivatives in their labelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
摘要翻译： 本发明涉及其标记形式的8-氮杂双环[3.2.1]辛-2-烯衍生物。 此外，本发明涉及所述衍生物在其标记或未标记形式的诊断方法中的用途，特别是用于体内受体成像（神经成像）。
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