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公开(公告)号:US20130244944A1
公开(公告)日:2013-09-19
申请号:US13731971
申请日:2012-12-31
申请人: Dan Yang , Xiang Li , Huiyan Zha
发明人: Dan Yang , Xiang Li , Huiyan Zha
IPC分类号: C07C335/16 , C07C259/06 , C07C275/28 , C07K5/062
CPC分类号: C07C335/16 , C07B2200/07 , C07C237/22 , C07C239/08 , C07C239/20 , C07C259/06 , C07C271/22 , C07C275/28 , C07D213/63 , C07D213/79 , C07D213/81 , C07K5/06034
摘要: Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
摘要翻译: 本文提供了可以在脂质双层或细胞膜中形成离子通道的自组装化合物和包含自组装化合物的离子通道形成组合物。 还提供了制造和使用由多个自组装化合物分子形成的离子通道的方法。 此外,提供了治疗或预防与离子通道功能障碍(包括氯化物通道)相关的病症和疾病的方法。