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公开(公告)号：US07858598B2
公开(公告)日：2010-12-28
申请号：US12034670
申请日：2008-02-21
申请人： Dan Yang , Zhen-Ning Sun , Yan Chen , Fengqin Liu
发明人： Dan Yang , Zhen-Ning Sun , Yan Chen , Fengqin Liu
CPC分类号： C07F5/022 , G01N21/6428 , G01N31/22 , Y10T436/19
摘要： Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.
摘要翻译： 本文提供了可用作直接或间接次氯酸或次氯酸盐的测量，检测和/或筛选试剂的化合物或次氯酸探针。 本文还提供了可用于直接或间接测量化学样品和生物样品（如细菌和生物体组织）中次氯酸或次氯酸盐的量的方法。 具体而言，该方法包括使本文公开的次氯酸探针与样品接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。 本文还提供了用于检测或筛选次氯酸或化合物的高通量筛选荧光方法，其可以直接或间接地增加或减少化学和生物样品中次氯酸或次氯酸盐的含量。
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公开(公告)号：US20080274560A1
公开(公告)日：2008-11-06
申请号：US12034670
申请日：2008-02-21
申请人： Dan Yang , Zhen-Ning Sun , Yan Chen , Fengqin Liu
发明人： Dan Yang , Zhen-Ning Sun , Yan Chen , Fengqin Liu
CPC分类号： C07F5/022 , G01N21/6428 , G01N31/22 , Y10T436/19
摘要： Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.
摘要翻译： 本文提供了可用作直接或间接次氯酸或次氯酸盐的测量，检测和/或筛选试剂的化合物或次氯酸探针。 本文还提供了可用于直接或间接测量化学样品和生物样品（如细菌和生物体组织）中次氯酸或次氯酸盐的量的方法。 具体而言，该方法包括使本文公开的次氯酸探针与样品接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。 本文还提供了用于检测或筛选次氯酸或化合物的高通量筛选荧光方法，其可以直接或间接地增加或减少化学和生物样品中次氯酸或次氯酸盐的含量。
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