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    Reagents for detection of hypochlorous acid
    1.
    发明授权
    Reagents for detection of hypochlorous acid 有权
    检测次氯酸的试剂

    公开(公告)号：US07858598B2

    公开(公告)日：2010-12-28

    申请号：US12034670

    申请日：2008-02-21

    申请人： Dan Yang ,  Zhen-Ning Sun ,  Yan Chen ,  Fengqin Liu

    发明人： Dan Yang ,  Zhen-Ning Sun ,  Yan Chen ,  Fengqin Liu

    IPC分类号： A01N55/08 ,  A61K31/69 ,  C07H23/00

    CPC分类号： C07F5/022 ,  G01N21/6428 ,  G01N31/22 ,  Y10T436/19

    摘要： Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.

    摘要翻译： 本文提供了可用作直接或间接次氯酸或次氯酸盐的测量，检测和/或筛选试剂的化合物或次氯酸探针。 本文还提供了可用于直接或间接测量化学样品和生物样品（如细菌和生物体组织）中次氯酸或次氯酸盐的量的方法。 具体而言，该方法包括使本文公开的次氯酸探针与样品接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。 本文还提供了用于检测或筛选次氯酸或化合物的高通量筛选荧光方法，其可以直接或间接地增加或减少化学和生物样品中次氯酸或次氯酸盐的含量。

    REAGENTS FOR DETECTION OF HYPOCHLOROUS ACID
    2.
    发明申请
    REAGENTS FOR DETECTION OF HYPOCHLOROUS ACID 有权
    用于检测嗜酸性粒细胞的试剂

    公开(公告)号：US20080274560A1

    公开(公告)日：2008-11-06

    申请号：US12034670

    申请日：2008-02-21

    申请人： Dan Yang ,  Zhen-Ning Sun ,  Yan Chen ,  Fengqin Liu

    发明人： Dan Yang ,  Zhen-Ning Sun ,  Yan Chen ,  Fengqin Liu

    IPC分类号： G01N33/58 ,  C07F5/02

    CPC分类号： C07F5/022 ,  G01N21/6428 ,  G01N31/22 ,  Y10T436/19

    摘要： Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.

    摘要翻译： 本文提供了可用作直接或间接次氯酸或次氯酸盐的测量，检测和/或筛选试剂的化合物或次氯酸探针。 本文还提供了可用于直接或间接测量化学样品和生物样品（如细菌和生物体组织）中次氯酸或次氯酸盐的量的方法。 具体而言，该方法包括使本文公开的次氯酸探针与样品接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。 本文还提供了用于检测或筛选次氯酸或化合物的高通量筛选荧光方法，其可以直接或间接地增加或减少化学和生物样品中次氯酸或次氯酸盐的含量。

    Reagents for highly specific detection of peroxynitrite
    3.
    发明申请
    Reagents for highly specific detection of peroxynitrite 有权
    高度特异性检测过氧亚硝酸盐的试剂

    公开(公告)号：US20070082403A1

    公开(公告)日：2007-04-12

    申请号：US11245529

    申请日：2005-10-07

    申请人： Dan Yang ,  Hua-Li Wang ,  Zhen-Ning Sun ,  Jian-Gang Shen

    发明人： Dan Yang ,  Hua-Li Wang ,  Zhen-Ning Sun ,  Jian-Gang Shen

    IPC分类号： G01N33/00

    CPC分类号： C07D207/34 ,  C07D493/10 ,  Y10T436/17

    摘要： This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.

    摘要翻译： 本发明提供了与过氧亚硝酸盐而不是其它活性氧和活性氮物质特异性反应的组合物。 本发明还提供了用于测量过氧亚硝酸盐的相关试剂。 本发明还提供了用于测量样品中过氧亚硝酸盐的相关方法，用于检测过氧亚硝酸盐的高通量筛选荧光方法和用于筛选增加或减少包含使用这些组合物和试剂的过氧亚硝酸盐生产的化合物的高通量方法。

    Reagents for highly specific detection of peroxynitrite
    4.
    发明授权
    Reagents for highly specific detection of peroxynitrite 有权
    高度特异性检测过氧亚硝酸盐的试剂

    公开(公告)号：US07705040B2

    公开(公告)日：2010-04-27

    申请号：US11245529

    申请日：2005-10-07

    申请人： Dan Yang ,  Hua-Li Wang ,  Zhen-Ning Sun ,  Jian-Gang Shen

    发明人： Dan Yang ,  Hua-Li Wang ,  Zhen-Ning Sun ,  Jian-Gang Shen

    IPC分类号： A61K31/55 ,  C07D309/00

    CPC分类号： C07D207/34 ,  C07D493/10 ,  Y10T436/17

    摘要： This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.

    摘要翻译： 本发明提供了与过氧亚硝酸盐而不是其它活性氧和活性氮物质特异性反应的组合物。 本发明还提供了用于测量过氧亚硝酸盐的相关试剂。 本发明还提供了用于测量样品中过氧亚硝酸盐的相关方法，用于检测过氧亚硝酸盐的高通量筛选荧光方法和用于筛选增加或减少包含使用这种组合物和试剂的过氧亚硝酸盐生产的化合物的高通量方法。

    Low cost backside illuminated CMOS image sensor package with high integration
    10.
    发明授权
    Low cost backside illuminated CMOS image sensor package with high integration 有权
    低成本背照式CMOS图像传感器封装，集成度高

    公开(公告)号：US08823126B2

    公开(公告)日：2014-09-02

    申请号：US13464939

    申请日：2012-05-04

    申请人： Dan Yang ,  Yat Kit Tsui ,  Shu Kin Yau ,  Pui Chung Law

    发明人： Dan Yang ,  Yat Kit Tsui ,  Shu Kin Yau ,  Pui Chung Law

    IPC分类号： H01L27/146

    CPC分类号： H01L27/1464 ,  H01L27/14618 ,  H01L27/14627 ,  H01L27/14632 ,  H01L27/14687 ,  H01L2924/0002 ,  H01L2924/00

    摘要： This invention discloses a backside illuminated image sensor without the need to involve a mechanical grinding process or a chemical-mechanical planarization process in fabrication, and a fabricating method thereof. In one embodiment, an image sensor comprises a semiconductor substrate, a plurality of light sensing elements in the semiconductor substrate, and a cavity formed in the semiconductor substrate. The light sensing elements are arranged in a substantially planar manner. The cavity has a base surface overlying the light sensing elements. The presence of the cavity allows the image to reach the light sensing elements through the cavity base surface. The cavity can be fabricated by etching the semiconductor substrate. Agitation may also be used when carrying out the etching.

    摘要翻译： 本发明公开了一种背面照明图像传感器，其制造方法不需要涉及机械研磨工艺或化学机械平面化工艺。 在一个实施例中，图像传感器包括半导体衬底，半导体衬底中的多个感光元件和形成在半导体衬底中的空腔。 光感测元件以基本上平面的方式布置。 空腔具有覆盖光敏元件的基面。 空腔的存在允许图像通过空腔基面到达光感测元件。 可以通过蚀刻半导体衬底来制造空腔。 进行蚀刻时也可以使用搅拌。