公开(公告)号：US11530209B2

公开(公告)日：2022-12-20

申请号：US16753536

申请日：2018-10-04

Applicant: Dana-Farber Cancer Institute, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Jun Qi ,  Anthony Varca ,  Li Chai

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US11999729B2

公开(公告)日：2024-06-04

申请号：US17978591

申请日：2022-11-01

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Jun Qi ,  Anthony Varca ,  Li Chai

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US20230365583A1

公开(公告)日：2023-11-16

申请号：US18020486

申请日：2021-08-10

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： Sara Buhrlage ,  Anthony Varca ,  Bin Hu

IPC: C07D495/14 ,  C07D495/04 ,  C07D491/048 ,  C07D471/04

CPC classification number: C07D495/14 ,  C07D495/04 ,  C07D491/048 ,  C07D471/04

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28) and methods of inhibiting USP28.

公开(公告)号：US20230265082A1

公开(公告)日：2023-08-24

申请号：US18020493

申请日：2021-08-10

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： Sara Buhrlage ,  Anthony Varca ,  Bin Hu

IPC: C07D413/04 ,  C07D413/14 ,  C07D413/06 ,  C07D413/12

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D413/06 ,  C07D413/12

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The disclosure also relates to a method of treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28) a method of treating cancer, and a method of inhibiting USP28, comprising administering to a subject in need thereof a compound of formula (I).

公开(公告)号：US20230115483A1

公开(公告)日：2023-04-13

申请号：US17978591

申请日：2022-11-01

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Jun Qi ,  Anthony Varca ,  Li Chai

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

Abstract: Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US20250034126A1

公开(公告)日：2025-01-30

申请号：US18898034

申请日：2024-09-26

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： James E. Bradner ,  Jun Qi ,  Alexander Federation ,  Zoe Jacobson ,  Anthony Varca

IPC: C07D417/12 ,  A61P35/00 ,  C07D277/54 ,  C07D405/04 ,  C07D417/14 ,  C07D471/04

Abstract: Provided herein are compounds useful as inhibitors of CBX. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US12129248B2

公开(公告)日：2024-10-29

申请号：US16335951

申请日：2017-09-25

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： James Bradner ,  Jun Qi ,  Alexander Federation ,  Zoe Jacobson ,  Anthony Varca

IPC: C07D417/12 ,  A61P35/00 ,  C07D277/54 ,  C07D405/04 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D417/12 ,  A61P35/00 ,  C07D277/54 ,  C07D405/04 ,  C07D417/14 ,  C07D471/04

Abstract: Provided herein are compounds useful as inhibitors of CBX. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US20230271918A1

公开(公告)日：2023-08-31

申请号：US18020492

申请日：2021-08-10

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： Sara Buhrlage ,  Anthony Varca ,  Bin Hu

IPC: C07C311/46 ,  C07C317/26 ,  C07D295/26 ,  C07D295/12 ,  C07D233/58 ,  C07C233/65 ,  C07D235/06

CPC classification number: C07C311/46 ,  C07C317/26 ,  C07D295/26 ,  C07D295/12 ,  C07D233/58 ,  C07C233/65 ,  C07D235/06

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and pharmaceutical composition comprising the compound of formula (I). The present composition also relates to methods treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28), methods of treating cancer, and methods of inhibiting USP28.

公开(公告)号：US20200317664A1

公开(公告)日：2020-10-08

申请号：US16753536

申请日：2018-10-04

Applicant: Dana-Farber Cancer Institute, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Jun Qi ,  Anthony Varca ,  Li Chai

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.

公开(公告)号：US20200024267A1

公开(公告)日：2020-01-23

申请号：US16335951

申请日：2017-09-25

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： James Bradner ,  Jun Qi ,  Alexander Federation ,  Zoe Jacobson ,  Anthony Varca

IPC: C07D417/12 ,  C07D405/04 ,  C07D417/14 ,  C07D471/04 ,  C07D277/54 ,  A61P35/00

Abstract: Provided herein are compounds useful as inhibitors of CBX. Also described are pharmaceutical compositions and medical uses of these compounds.