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    Methods of coating an implantable device having depots formed in a surface thereof
    5.
    发明授权
    Methods of coating an implantable device having depots formed in a surface thereof 有权
    在其表面形成具有贮库的可植入装置的方法

    公开(公告)号：US06506437B1

    公开(公告)日：2003-01-14

    申请号：US09690907

    申请日：2000-10-17

    申请人： Sameer Harish ,  Steven Z. Wu ,  Kurt W. Scheinpflug ,  Brandon Yoe

    发明人： Sameer Harish ,  Steven Z. Wu ,  Kurt W. Scheinpflug ,  Brandon Yoe

    IPC分类号： B05D300

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/606

    摘要： The present invention provides methods of coating an implantable device, such as a stent or a graft, having a plurality of depots formed in a surface thereof. An exemplary method includes applying a composition including a polymer and a solvent to the implantable device proximate to the depots. Such application of the composition is performed at a first gas pressure. The method also includes applying a second gas pressure, which is greater than the first gas pressure, to the composition-coated device so that air pockets in the depots are eliminated, or at least reduced in size. The method also includes the act of removing the solvent from the composition to form a coating. An implantable device coated in accordance with the method is also provided. The compositions employed in the methods may include one or more therapeutic substances such as antineoplastics, antimitotics, antiinflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, antiallergics, radioisotopes, and combinations thereof.

    摘要翻译： 本发明提供了在其表面形成有多个贮库的可植入装置（例如支架或移植物）的涂覆方法。 示例性的方法包括将包含聚合物和溶剂的组合物施加到靠近储库的可植入装置。 组合物的这种施用在第一气体压力下进行。 该方法还包括将大于第一气体压力的第二气体压力施加到组合物涂覆的装置，使得储存库中的气穴被消除或至少减小尺寸。 该方法还包括从组合物中除去溶剂以形成涂层的作用。 还提供了根据该方法涂覆的可植入装置。该方法中使用的组合物可包括一种或多种治疗物质，例如抗肿瘤药，抗虚菌药，抗炎药，抗血小板剂，抗凝剂，抗纤维蛋白，抗血栓素，抗增生剂，抗生素，抗氧化剂，抗过敏药， 放射性同位素及其组合。