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    Methods of coating an implantable device having depots formed in a surface thereof
    1.
    发明授权
    Methods of coating an implantable device having depots formed in a surface thereof 有权
    在其表面形成具有贮库的可植入装置的方法

    公开(公告)号：US06506437B1

    公开(公告)日：2003-01-14

    申请号：US09690907

    申请日：2000-10-17

    申请人： Sameer Harish ,  Steven Z. Wu ,  Kurt W. Scheinpflug ,  Brandon Yoe

    发明人： Sameer Harish ,  Steven Z. Wu ,  Kurt W. Scheinpflug ,  Brandon Yoe

    IPC分类号： B05D300

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/606

    摘要： The present invention provides methods of coating an implantable device, such as a stent or a graft, having a plurality of depots formed in a surface thereof. An exemplary method includes applying a composition including a polymer and a solvent to the implantable device proximate to the depots. Such application of the composition is performed at a first gas pressure. The method also includes applying a second gas pressure, which is greater than the first gas pressure, to the composition-coated device so that air pockets in the depots are eliminated, or at least reduced in size. The method also includes the act of removing the solvent from the composition to form a coating. An implantable device coated in accordance with the method is also provided. The compositions employed in the methods may include one or more therapeutic substances such as antineoplastics, antimitotics, antiinflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, antiallergics, radioisotopes, and combinations thereof.

    摘要翻译： 本发明提供了在其表面形成有多个贮库的可植入装置（例如支架或移植物）的涂覆方法。 示例性的方法包括将包含聚合物和溶剂的组合物施加到靠近储库的可植入装置。 组合物的这种施用在第一气体压力下进行。 该方法还包括将大于第一气体压力的第二气体压力施加到组合物涂覆的装置，使得储存库中的气穴被消除或至少减小尺寸。 该方法还包括从组合物中除去溶剂以形成涂层的作用。 还提供了根据该方法涂覆的可植入装置。该方法中使用的组合物可包括一种或多种治疗物质，例如抗肿瘤药，抗虚菌药，抗炎药，抗血小板剂，抗凝剂，抗纤维蛋白，抗血栓素，抗增生剂，抗生素，抗氧化剂，抗过敏药， 放射性同位素及其组合。

    Biocompatible coating for a prosthesis and a method of forming the same
    2.
    发明授权
    Biocompatible coating for a prosthesis and a method of forming the same 有权
    用于假体的生物相容性涂层及其形成方法

    公开(公告)号：US06713119B2

    公开(公告)日：2004-03-30

    申请号：US09470559

    申请日：1999-12-23

    申请人： Syed F. A. Hossainy ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daniel A. Castro ,  Sameer Harish ,  Steven Z. Wu

    发明人： Syed F. A. Hossainy ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daniel A. Castro ,  Sameer Harish ,  Steven Z. Wu

    IPC分类号： A61F202

    CPC分类号： A61L33/0011 ,  A61F2/91 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  C08L29/04

    摘要： A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.

    摘要翻译： 公开了一种用于假体的涂层，例如支架和用于形成涂层的组合物。 该涂层可用作底漆，允许诸如聚合物的物质被假体有效地固定。 或者，涂层可以用作储存器，允许治疗物质局部和持续释放到生物组织。 组合物可以由乙烯乙烯醇共聚物和二甲基亚砜溶剂形成，具有或不具有治疗物质。 或者，组合物可以由乙烯乙烯醇共聚物，二甲基亚砜溶剂和润湿流体形成，具有或不具有治疗物质。 将组合物施加到假体的表面，并且基本上所有的二甲基亚砜溶剂或二甲基亚砜溶剂/润湿流体被除去或允许蒸发以形成涂层。

    Microparticle coated medical device
    3.
    发明授权
    Microparticle coated medical device 有权
    微粒涂层医疗器械

    公开(公告)号：US06656506B1

    公开(公告)日：2003-12-02

    申请号：US09851877

    申请日：2001-05-09

    申请人： Steven Z. Wu ,  Syed F. A. Hossainy ,  Sameer Harish ,  Deborra Sanders-Millare ,  Daryush Mirzaee

    发明人： Steven Z. Wu ,  Syed F. A. Hossainy ,  Sameer Harish ,  Deborra Sanders-Millare ,  Daryush Mirzaee

    IPC分类号： A61K914

    CPC分类号： A61L31/16 ,  A61K9/1635 ,  A61K9/1652 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/622 ,  C08L29/04

    摘要： A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

    摘要翻译： 将药物负载的微粒施加到医疗装置上，用于随后应用于生物组织。 公开了一种配制载药微粒并将其施加到诸如支架的医疗装置的表面上的方法。 通过将药物与各种化学溶液组合来配制载药微粒。 可以通过改变化学品/溶液的比例来改变微粒中包含的微粒的特定尺寸和药物的量。 除了各种药物之外，治疗物质和放射性同位素也可以加载到微粒中。 将负载药物的微粒悬浮在形成聚合物基质的聚合物溶液中。 聚合物基质可以通过浸渍，喷雾或其组合施加到整个表面或仅应用于医疗装置的选定部分。

    Implantable drug delivery prosthesis
    5.
    发明授权
    Implantable drug delivery prosthesis 失效
    植入式药物输送假体

    公开(公告)号：US06979347B1

    公开(公告)日：2005-12-27

    申请号：US09695022

    申请日：2000-10-23

    申请人： Steven Z. Wu ,  Deborra Sanders-Millare ,  Sameer Harish ,  Ryan J. Santos ,  Li Chen

    发明人： Steven Z. Wu ,  Deborra Sanders-Millare ,  Sameer Harish ,  Ryan J. Santos ,  Li Chen

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/14 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/44

    摘要： An apparatus and associated method for delivering a therapeutic substance to a vascular lumen, using an implantable prosthesis, such as a stent, which has grooves or trenches formed thereon. The grooves are formed on specific regions of the stent struts to increase the flexibility of the stent. The grooves also provide a therapeutic material carrying capability for treating intravascular ailments, such as instent restenosis and thrombosis. The therapeutic material loading of the grooves can be accomplished in several ways. For example, a pure therapeutic material or a pre-mixed material with a polymer solution, which enhances the adhesion properties of the material, may be deposited directly in to the grooves using conventional spray or modified dip techniques. In another example, a microextruded monofilament therapeutic material can be wound about the stent, such that the monofilament becomes embedded in the grooves.

    摘要翻译： 一种用于将治疗物质输送到血管内腔的装置和相关方法，所述方法使用在其上形成有凹槽或沟槽的可植入假体（例如支架）。 在支架支架的特定区域上形成凹槽以增加支架的柔性。 凹槽还提供用于治疗血管内疾病（例如局限性再狭窄和血栓形成）的治疗材料携带能力。 凹槽的治疗材料加载可以以几种方式实现。 例如，可以使用常规的喷雾或改性浸渍技术将纯化处理材料或具有聚合物溶液的预混合材料直接沉积到凹槽中，所述聚合物溶液增强材料的粘合性能。 在另一个实例中，微挤压单丝治疗材料可以缠绕在支架上，使得单丝嵌入槽中。

    Implantable medical device having protruding surface structures for drug delivery and cover attachment
    6.
    发明授权
    Implantable medical device having protruding surface structures for drug delivery and cover attachment 有权
    具有用于药物递送和盖附接的突出表面结构的植入式医疗装置

    公开(公告)号：US06254632B1

    公开(公告)日：2001-07-03

    申请号：US09675044

    申请日：2000-09-28

    申请人： Steven Z. Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya

    发明人： Steven Z. Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya

    IPC分类号： A61F206

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0068

    摘要： A method for forming an implantable medical device, such as a stent, covered stent, or synthetic stent graft, is provided. Protruding structures are formed on a surface of the device. The protruding structures have a central depression region surrounded by a lip. The protruding structures can have a variety of shapes, including circular and ovular shapes, or the protruding structure can form a groove. The protruding structures can be used to engage a cover. Glue can be added to the protruding structures to help secure the cover. The protruding structures can also contain a therapeutic substance or substances for release in situ. The protruding structures can be formed using a laser discharge to create a hole in the stent surface followed by directing a pressurized stream of grit at the surface.

    摘要翻译： 提供了一种用于形成可植入医疗装置的方法，例如支架，覆盖支架或合成支架移植物。 突出结构形成在装置的表面上。 突出结构具有由唇部包围的中心凹陷区域。 突出结构可以具有各种形状，包括圆形和卵形，或者突出结构可以形成凹槽。 突出结构可用于接合盖。 可以将胶水添加到突出结构中以帮助固定盖。 突出结构还可以含有用于原位释放的治疗物质或物质。 可以使用激光放电来形成突出结构，以在支架表面中产生孔，随后在表面引导加压的砂粒流。

    Methods of forming microparticle coated medical device
    7.
    发明授权
    Methods of forming microparticle coated medical device 失效
    形成微粒涂层医疗器械的方法

    公开(公告)号：US08361539B2

    公开(公告)日：2013-01-29

    申请号：US10663181

    申请日：2003-09-15

    申请人： Steven Z. Wu ,  Syed F. A. Hossainy ,  Sameer Harish ,  Deborra Sanders-Millare ,  Daryush Mirzaee

    发明人： Steven Z. Wu ,  Syed F. A. Hossainy ,  Sameer Harish ,  Deborra Sanders-Millare ,  Daryush Mirzaee

    IPC分类号： B05D3/00

    CPC分类号： A61L31/16 ,  A61K9/1635 ,  A61K9/1652 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/622 ,  C08L29/04

    摘要： A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

    摘要翻译： 将药物负载的微粒施加到医疗装置上，用于随后应用于生物组织。 公开了一种配制载药微粒并将其施加到诸如支架的医疗装置的表面上的方法。 通过将药物与各种化学溶液组合来配制载药微粒。 可以通过改变化学品/溶液的比例来改变微粒中包含的微粒的特定尺寸和药物的量。 除了各种药物之外，治疗物质和放射性同位素也可以加载到微粒中。 将负载药物的微粒悬浮在形成聚合物基质的聚合物溶液中。 聚合物基质可以通过浸渍，喷雾或其组合施加到整个表面或仅应用于医疗装置的选定部分。