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公开(公告)号：US10053407B2
公开(公告)日：2018-08-21
申请号：US15609159
申请日：2017-05-31
CPC分类号： C07C39/23 , C07B2200/13 , C07C37/68 , C07C2601/16
摘要： Solid cannabidivarin, crystalline cannabidivarin, (R,R)-(−)-crystalline cannabidivarin, (S,S)-(+)-crystalline cannabidivarin and substantially pure forms thereof are disclosed herein. Further disclosed are methods of making such cannabidivarin, compositions and formulations comprising such cannabidivarin, and methods of treating disease with such cannabidivarin.
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公开(公告)号：US20170349517A1
公开(公告)日：2017-12-07
申请号：US15609159
申请日：2017-05-31
IPC分类号： C07C39/23 , C07C37/68 , C07C2601/16
CPC分类号： C07C39/23 , C07B2200/13 , C07C37/68 , C07C2601/16
摘要： Solid cannabidivarin, crystalline cannabidivarin, (R,R)-(−)-crystalline cannabidivarin, (S,S)-(+)-crystalline cannabidivarin and substantially pure forms thereof are disclosed herein. Further disclosed are methods of making such cannabidivarin, compositions and formulations comprising such cannabidivarin, and methods of treating disease with such cannabidivarin.
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公开(公告)号：US20130280768A1
公开(公告)日：2013-10-24
申请号：US13819985
申请日：2011-09-01
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C07B59/002 , C07D473/10
摘要： The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
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4.发明申请PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION 有权从相关的酮中制备出具有良好活性的去除的二级酒精的方法，而不会减少去除毒素公开(公告)号：US20140017739A1
公开(公告)日：2014-01-16
申请号：US13820003
申请日：2011-09-01
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C07B59/002 , C07D473/04 , C12Y101/01184
摘要： The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
摘要翻译： 本发明提供了用于制备对映体富集的氘化仲醇而不减少氘掺入的方便和有效的方法。
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5.发明授权公开(公告)号：US09074233B2
公开(公告)日：2015-07-07
申请号：US13819985
申请日：2011-09-01
IPC分类号： C12P17/18 , C07B35/02 , C07D473/10 , C07B59/00
CPC分类号： C12P17/182 , C07B59/002 , C07D473/10
摘要： The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
摘要翻译： 本发明提供了通过使用酮还原酶或羰基还原酶而不减少氘掺入来制备式1-A的对映体富集的氘代仲醇的方法。
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6.发明授权公开(公告)号：US09085788B2
公开(公告)日：2015-07-21
申请号：US13820003
申请日：2011-09-01
IPC分类号： C12P17/18 , C07B59/00 , C07D473/04
CPC分类号： C12P17/182 , C07B59/002 , C07D473/04 , C12Y101/01184
摘要： The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.
摘要翻译： 本发明提供了用于制备对映体富集的氘化仲醇而不减少氘掺入的方便和有效的方法。
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7.发明授权Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides 失效大规模制备2'，3'-二脱氢-2'，3'-二脱氧核苷的方法
公开(公告)号：US5539099A
公开(公告)日：1996-07-23
申请号：US309636
申请日：1994-09-23
IPC分类号： C07H19/073 , C07H19/06 , C07H1/00
CPC分类号： C07H19/06
摘要： An improved process suitable for large-scale production of 2',3'-didehydro-3'-deoxythymidine (d4T) and close analogs is disclosed. The improved process yields d4T in high yield and purity without the use of hazardous reactions or reagents and incorporates several process improvements important on a large scale including a novel purification step involving the isolation of a d4T.N-methylpyrrolidinone solvate.
摘要翻译： 公开了适用于大规模生产2'，3'-二脱氢-3'-脱氧胸苷（d4T）和近似类似物的改进方法。 改进的方法产生高产率和纯度的d4T，而不使用危险反应或试剂，并且包括大量重要的若干工艺改进，包括分离d4T.N-甲基吡咯烷酮溶剂合物的新型纯化步骤。
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