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    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    1.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US07642054B2

    公开(公告)日：2010-01-05

    申请号：US11225661

    申请日：2005-09-12

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and Intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed In certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达，以及在前列腺癌中，因此该家族的成员被称为前列腺的“STRAP”蛇纹石TRANmembrane抗原。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STRAP-1在某些其他人类癌症中高度过度表达。

    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    3.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US07928201B2

    公开(公告)日：2011-04-19

    申请号：US12575092

    申请日：2009-10-07

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    IPC分类号： C07K16/00

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

    Antibodies immunospecific for STEAP1
    4.
    发明授权
    Antibodies immunospecific for STEAP1 有权
    针对STEAP1免疫特异性的抗体

    公开(公告)号：US07053186B2

    公开(公告)日：2006-05-30

    申请号：US10011095

    申请日：2001-12-06

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STREPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STREP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要在前列腺以及前列腺癌中表达，因此该家族的成员被称为“STRAP”（前列腺的蛇纹状跨膜抗原）。 本文描述和表征了四种特定的人STEAP。 人类STREP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 前列腺癌各阶段的STREP-1蛋白表达维持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

    PHELIX: a testis-specific protein expressed in cancer
    5.
    发明授权
    PHELIX: a testis-specific protein expressed in cancer 失效
    PHELIX：在癌症中表达的睾丸特异性蛋白

    公开(公告)号：US07008779B1

    公开(公告)日：2006-03-07

    申请号：US09389000

    申请日：1999-08-31

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Arthur B. Raitano

    IPC分类号： C12H15/00

    CPC分类号： C07K14/4748 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00

    摘要： Described is a novel gene and its encoded basic Helix Loop Helix protein, termed PHELIX, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express PHELIX, particularly including prostate cancer, bladder cancer, ovarian cancer and testicular cancer. In human normal tissues, PHELIX is only expressed in testis tissue. However, PHELIX is expressed at high levels in prostate cancer cells and in other cancer cells. The structure of PHELIX suggests that it may function as a transcription factor that normally exhibits a testis-specific expression pattern but is turned on in prostate cancer as well as in other cancers.

    摘要翻译： 描述了一种新型基因及其编码的基本的Helix Loop Helix蛋白，称为PHELIX，以及用于治疗表达PHELIX的各种癌症的诊断和治疗方法和组合物，特别包括前列腺癌，膀胱癌，卵巢癌和睾丸癌。 在人正常组织中，PHELIX仅在睾丸组织中表达。 然而，PHELIX在前列腺癌细胞和其他癌细胞中以高水平表达。 PHELIX的结构表明它可能作为转录因子起作用，其通常表现出睾丸特异性表达模式，但在前列腺癌以及其他癌症中开启。

    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    6.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US06329503B1

    公开(公告)日：2001-12-11

    申请号：US09323873

    申请日：1999-06-01

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    IPC分类号： C07K100

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    8.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US07611904B2

    公开(公告)日：2009-11-03

    申请号：US11580538

    申请日：2006-10-12

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen Chappell Mitchell

    IPC分类号： G01N33/53

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (SIX Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的第六跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    9.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US07575749B2

    公开(公告)日：2009-08-18

    申请号：US10858887

    申请日：2004-06-01

    申请人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

    发明人： Daniel E. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

    IPC分类号： A61K39/38

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。