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    Fenugreek seed bio-active compositions and methods for extracting same
    5.
    发明授权
    Fenugreek seed bio-active compositions and methods for extracting same 有权
    葫芦巴种子生物活性成分及其提取方法

    公开(公告)号：US07338675B2

    公开(公告)日：2008-03-04

    申请号：US10434444

    申请日：2003-05-07

    申请人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Shi Zhou

    发明人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Shi Zhou

    IPC分类号： A01N65/00 ,  A01N37/30 ,  A01N37/12

    CPC分类号： A61K36/48

    摘要： A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells. Preferably, the composition of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine and gamma-amino butyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. A method for extracting a composition of bio-active compounds from fenugreek seeds is also disclosed, wherein the method comprises the steps of: (1) providing a plurality of fenugreek seeds; (2) preparing the fenugreek seeds; and (3) extracting a composition of bio-active compounds from the fenugreek seeds, wherein the bio-active compounds comprise 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine and gamma-amino butyrate. The composition of bio-active compounds and methods for extraction of same preferably include between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids.

    摘要翻译： 生物活性化合物的组合物和促进和支持葡萄糖和碳水化合物进入肌肉细胞的代谢和转运的方法。 优选地，生物活性化合物的组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸 ，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸酯。 在本发明的一个目前优选的实施方案中，从葫芦巴种子中提取生物活性化合物。 还公开了从葫芦巴种子提取生物活性化合物的组合物的方法，其中所述方法包括以下步骤：（1）提供多种葫芦巴种子; （2）准备葫芦巴种子; （3）从葫芦巴种子提取生物活性化合物的组合物，其中所述生物活性化合物包含4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸 ，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸，亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，赖氨酸，组氨酸和γ-氨基丁酸。 生物活性化合物的组成和其提取方法优选包括约10％至70％的4-羟基异亮氨酸和约20％至40％的氨基酸。

    Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed
    6.
    发明授权
    Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed 有权
    从葫芦巴种子得到，分离和/或提取氨基酸组合物的方法

    公开(公告)号：US07645466B2

    公开(公告)日：2010-01-12

    申请号：US11069747

    申请日：2005-03-01

    申请人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing S. Zhou

    发明人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing S. Zhou

    IPC分类号： A61K36/48

    CPC分类号： A61K36/48 ,  A61K36/286 ,  A61K36/55 ,  A61K36/88 ,  A61K36/8962 ,  A61K36/9066 ,  A61K2300/00

    摘要： The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, omithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds.

    摘要翻译： 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸，生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物， 维生素，矿物质和碳水化合物。 优选地，生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸，天冬氨酸，苏氨酸，丝氨酸，谷氨酸，脯氨酸，甘氨酸，丙氨酸，半胱氨酸，缬氨酸，甲硫氨酸，异亮氨酸， 亮氨酸，色氨酸，苯丙氨酸，鸟氨酸，脯氨酸，赖氨酸，组氨酸和γ-氨基丁酸。 生物活性化合物的组成优选包括约10％至约70％的4-羟基异亮氨酸和约20％至约40％的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生，分离和/或提取。

    Method for increasing muscle mass and strength through administration of adenosine triphosphate
    8.
    发明授权
    Method for increasing muscle mass and strength through administration of adenosine triphosphate 有权
    通过施用三磷酸腺苷来增加肌肉质量和强度的方法

    公开(公告)号：US07629329B2

    公开(公告)日：2009-12-08

    申请号：US11069746

    申请日：2005-02-28

    申请人： Steve S. Lee ,  Richard B. Hynson ,  Joe Zhou

    发明人： Steve S. Lee ,  Richard B. Hynson ,  Joe Zhou

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/7076

    摘要： The present invention is directed to compositions having an effective amount of Adenosine Triphosphate (“ATP”) sufficient to effect intracellular and extracellular concentrations of ATP in a mammal to improve anaerobic exercise capacity by increasing muscle size and/or strength and methods for using the same. Preferably, a gastric acid secretion inhibitory coating is applied to the effective amount of ATP in a manner that protects the ATP from degradation by gastric juices. ATP compositions of the present invention may be administered in nutraceutical or functional food dosage forms, including oral and non-oral delivery forms. In addition, the effective amount of ATP maybe combined with amino acids, botanicals, functional foods, herbals, nucleotides, nutraceuticals, nutrients, pharmaceuticals, proteins, and/or vitamins in an effort to enhance the targeted activity of the composition.

    摘要翻译： 本发明涉及具有足以实现哺乳动物中ATP的细胞内和细胞外浓度的有效量的三磷酸腺苷（“ATP”）的组合物，以通过增加肌肉尺寸和/或强度来提高厌氧运动能力，并且使用该方法 。 优选地，以有效量的ATP将胃酸分泌抑制性涂层以保护ATP免受胃液降解的方式施用。 本发明的ATP组合物可以以营养食品或功能性食品剂型给药，包括口服和非口服递送形式。 此外，ATP的有效量可以与氨基酸，植物药，功能性食品，草药，核苷酸，营养品，营养素，药物，蛋白质和/或维生素组合，以增强组合物的靶向活性。

    Methods for improving glycemic control in humans
    10.
    发明申请
    Methods for improving glycemic control in humans 审中-公开
    改善人体血糖控制的方法

    公开(公告)号：US20090076111A1

    公开(公告)日：2009-03-19

    申请号：US11975192

    申请日：2007-10-18

    申请人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Shi Zhou

    发明人： Steve S. Lee ,  Richard B. Hynson ,  Ke-Qin Zhang ,  Wu-Zhou Li ,  Jing Shi Zhou

    IPC分类号： A61K31/197 ,  A61P3/00 ,  A61K31/4172

    CPC分类号： A61K31/198 ,  A61K31/401 ,  A61K31/4745 ,  A61K36/48 ,  A61K2300/00

    摘要： The present invention is directed to methods for improving glycemic control in humans and animals comprising the step of administering a composition comprising an amino acid content including 4-hydroxyisoleucine in an amount between about 60% and about 70% of a total weight of the amino acid content, together with one or more amino acids selected from the group consisting of glutamate, aspartate, arginine, cysteine, threonine, serine, glycine, alanine, valine, methionine, isoleucine, and histidine (inclusive of any chemical salts, anhydrides, or isomers of any of the foregoing), in addition to, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Fasting blood glucose and glucose tolerance were studied in normal human subjects, in human subjects diagnosed with Metabolic Syndrome X, and in diabetic rats by means of dosing the subjects with compositions comprising 4-hydroxyisoleucine in an amount between about 20% and about 30% of the total weight of the composition, wherein improving glycemic control in standard glucose tolerance tests.

    摘要翻译： 本发明涉及用于改善人和动物血糖控制的方法，包括以下步骤：施用含有包含4-羟基异亮氨酸的氨基酸含量的组合物，其量为氨基酸总重量的约60％至约70％ 含有一种或多种选自谷氨酸，天冬氨酸，精氨酸，半胱氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，缬氨酸，甲硫氨酸，异亮氨酸和组氨酸的氨基酸（包括任何化学盐，酸酐或异构体 除了生物碱，糖苷，挥发性油，皂角苷，皂甙元，甘露聚糖，类黄酮，脂肪酸，维生素和维生素，矿物质和碳水化合物之外。 在正常人受试者，诊断为代谢综合征X的人类受试者中以及在糖尿病大鼠中通过给受试者给予包含4-羟基异亮氨酸的组合物的空腹血糖和葡萄糖耐量在约20％至约30％之间的量 组合物的总重量，其中改善标准葡萄糖耐量试验中的血糖控制。