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    QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
    6.
    发明申请
    QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS 有权
    喹诺酮 - 羧酰胺化合物作为5-HT4受体激动剂

    公开(公告)号：US20100285519A1

    公开(公告)日：2010-11-11

    申请号：US12782915

    申请日：2010-05-19

    申请人： Daniel Marquess ,  Paul R. Fatheree ,  S. Derek Turner ,  Daniel D. Long ,  Seok-ki Choi ,  Adam A. Goldblum ,  Daniel Genov

    发明人： Daniel Marquess ,  Paul R. Fatheree ,  S. Derek Turner ,  Daniel D. Long ,  Seok-ki Choi ,  Adam A. Goldblum ,  Daniel Genov

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/5088 ,  C07D451/04

    摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R1 is hydrogen, halo, hydroxy, C1-4 alkyl, or C1-4 alkoxy; R2 is C3-4 alkyl, or C3-6cycloalkyl; R3 is hydrogen or C1-3 alkyl: R4 is S(O)2R6 or C(O)R7; R5 is hydrogen, C1-3alkyl, C2-3 alkyl substituted with —OH or C1-3 alkoxy, or —CH2-pyrydyl; R6 is C1-3 alkyl; or R5 and R6 taken together from C3-4 alkylenyl; and R7 is hydrogen, C1-3alkyl, or pyrydyl; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

    摘要翻译： 本发明提供式（I）的新型喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性相关的疾病，以及可用于制备这些化合物的方法和中间体。 其中; R1是氢，卤素，羟基，C1-4烷基或C1-4烷氧基; R2是C3-4烷基或C3-6环烷基; R3是氢或C1-3烷基：R4是S（O）2R6或C（O）R7; R5是氢，C1-3烷基，被-OH或C1-3烷氧基取代的C2-3烷基，或-CH2-吡喃二基; R6是C1-3烷基; 或R 5和R 6一起为C3-4亚烷基; 并且R 7是氢，C 1-3烷基或吡喃基; 或其药学上可接受的盐或溶剂合物或立体异构体。

    Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
    7.
    发明授权
    Quinolinone-carboxamide compounds as 5-HT4 receptor agonists 有权
    喹啉酮 - 甲酰胺化合物作为5-HT 4受体激动剂

    公开(公告)号：US08309575B2

    公开(公告)日：2012-11-13

    申请号：US12782915

    申请日：2010-05-19

    申请人： Daniel Marquess ,  Paul R. Fatheree ,  S. Derek Turner ,  Daniel D. Long ,  Seok-ki Choi ,  Adam A. Goldblum ,  Daniel Genov

    发明人： Daniel Marquess ,  Paul R. Fatheree ,  S. Derek Turner ,  Daniel D. Long ,  Seok-ki Choi ,  Adam A. Goldblum ,  Daniel Genov

    IPC分类号： A61K31/47

    CPC分类号： G01N33/5088 ,  C07D451/04

    摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R1 is hydrogen, halo, hydroxy, C1-4 alkyl, or C1-4 alkoxy; R2 is C3-4 alkyl, or C3-6cycloalkyl; R3 is hydrogen or C1-3 alkyl: R4 is S(O)2R6 or C(O)R7; R5 is hydrogen, C1-3alkyl, C2-3 alkyl substituted with —OH or C1-3 alkoxy, or —CH2-pyrydyl; R6 is C1-3 alkyl; or R5 and R6 taken together from C3-4 alkylenyl; and R7 is hydrogen, C1-3alkyl, or pyrydyl; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

    摘要翻译： 本发明提供式（I）的新型喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性相关的疾病，以及可用于制备这些化合物的方法和中间体。 其中; R1是氢，卤素，羟基，C1-4烷基或C1-4烷氧基; R2是C3-4烷基或C3-6环烷基; R3是氢或C1-3烷基：R4是S（O）2R6或C（O）R7; R5是氢，C1-3烷基，被-OH或C1-3烷氧基取代的C2-3烷基，或-CH2-吡喃二基; R6是C1-3烷基; 或R 5和R 6一起为C3-4亚烷基; 并且R 7是氢，C 1-3烷基或吡喃基; 或其药学上可接受的盐或溶剂合物或立体异构体。