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1.发明授权Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging 有权持久性发光纳米粒子以体内光学成像诊断剂的形式使用公开(公告)号：US08709383B2
公开(公告)日：2014-04-29
申请号：US12091571
申请日：2006-10-30
申请人： Daniel Scherman , Michel Bessodes , Corinne Chaneac , Didier Louis Gourier , Jean-Pierre Jolivet , Quentin Le Masne De Chermont , Serge Maitrejean , Fabienne Sylvie Pelle
发明人： Daniel Scherman , Michel Bessodes , Corinne Chaneac , Didier Louis Gourier , Jean-Pierre Jolivet , Quentin Le Masne De Chermont , Serge Maitrejean , Fabienne Sylvie Pelle
IPC分类号： A61K49/00
CPC分类号： G01N33/587 , A61K49/0067 , B82Y15/00
摘要： The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.
摘要翻译： 本发明涉及使用持续性发光纳米颗粒，如果需要，以体内光学成像的诊断剂的形式进行官能化。 所述纳米颗粒优选由选自以下的化合物组成：（1）硅酸盐，铝酸盐，硅铝酸盐，锗酸盐，钛酸盐，氧硫化物，磷酸盐和钒酸盐，其中所述化合物含有至少一种类型的金属氧化物，（2） 选自锌，锶和钙中的至少一种金属离子，和（3）金属氧化物，其中所述化合物掺杂有至少一种稀土离子，并且可能含有至少一种过渡金属离子。 在优选的实施方案中，诊断剂用于生物体血管成像。 还公开了通过使用所述预功能化纳米颗粒在体外检测或定量样品中生物或化学感兴趣的物质的方法和试剂盒。
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2.发明申请PERSISTENT LUMINESCENCE NANOPARTICLES USED IN THE FORM OF A DIAGNOSIS AGENT FOR IN VIVO OPTICAL IMAGING 有权用于血管成像的诊断代理形式中使用的单次发光纳米颗粒公开(公告)号：US20090155173A1
公开(公告)日：2009-06-18
申请号：US12091571
申请日：2006-10-30
申请人： Daniel Scherman , Michel Bessodes , Corinne Chaneac , Didier Louis Gourier , Jean-Pierre Jolivet , Quentin Le Masne De Chermont , Serge Maitrejean , Fabienne Sylvie Pelle
发明人： Daniel Scherman , Michel Bessodes , Corinne Chaneac , Didier Louis Gourier , Jean-Pierre Jolivet , Quentin Le Masne De Chermont , Serge Maitrejean , Fabienne Sylvie Pelle
CPC分类号： G01N33/587 , A61K49/0067 , B82Y15/00
摘要： The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularisation imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.
摘要翻译： 本发明涉及使用持续性发光纳米颗粒，如果需要，以体内光学成像的诊断剂的形式进行官能化。 所述纳米颗粒优选由选自以下的化合物组成：（1）硅酸盐，铝酸盐，硅铝酸盐，锗酸盐，钛酸盐，氧硫化物，磷酸盐和钒酸盐，其中所述化合物含有至少一种类型的金属氧化物，（2） 选自锌，锶和钙中的至少一种金属离子，和（3）金属氧化物，其中所述化合物掺杂有至少一种稀土离子，并且可能含有至少一种过渡金属离子。 在优选实施方案中，诊断剂用于生物体血管成像。 还公开了通过使用所述预功能化纳米颗粒在体外检测或定量样品中生物或化学感兴趣的物质的方法和试剂盒。
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公开(公告)号：US20090066960A1
公开(公告)日：2009-03-12
申请号：US12048052
申请日：2008-03-13
IPC分类号： G01N21/55
CPC分类号： G01N21/763 , G01N21/6456 , G01N21/6486
摘要： A luminescence imaging installation is disclosed comprising a lightproof enclosure containing: a support receiving a sample to be imaged; a detector detecting a luminescence image from the sample to be imaged; and a light reflector device reflecting light towards the detector. The light reflector device surrounds the support at least in part and presents at least two portions that are inclined relative to each other, each reflecting light towards the detector.
摘要翻译： 公开了一种发光成像装置，其包括防光外壳，其包含：接收待成像样品的支架; 检测来自要成像的样品的发光图像的检测器; 以及将光反射到检测器的光反射器装置。 光反射器装置至少部分地围绕支撑件并且呈现相对于彼此倾斜的至少两个部分，每个部分朝向检测器反射光。
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公开(公告)号：US20120002101A1
公开(公告)日：2012-01-05
申请号：US12995227
申请日：2009-05-29
IPC分类号： H04N5/225
CPC分类号： G01N21/763 , A61B5/0059 , A61B2503/40 , G01B11/24 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/1772 , G01N2021/1785 , G01N2021/6465
摘要： The imaging apparatus comprises a light-tight enclosure in which are enclosed: a detector adapted to detect a light signal emitted from a sample, a reflecting device comprising first and second reflecting portions reflecting toward first and second portions of the detector a signal emitted from first and second portions of the sample, the second reflecting portion reflecting toward a third portion of the detector a signal emitted from a the third portion of the sample and previously reflected by the first reflecting portion, a fourth portion of the detector directly detecting a signal emitted from a fourth portion of the sample.
摘要翻译： 所述成像装置包括封闭的不透光外壳：适于检测从样品发射的光信号的检测器，反射装置，包括朝向检测器的第一和第二部分反射的第一和第二反射部分，该信号从第一 和第二部分的样品，第二反射部分向检测器的第三部分反射从样品的第三部分发射并预先被第一反射部分反射的信号，检测器的第四部分直接检测发射的信号 从样品的第四部分。
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公开(公告)号：US07834989B2
公开(公告)日：2010-11-16
申请号：US12048052
申请日：2008-03-13
IPC分类号： G01N21/00
CPC分类号： G01N21/763 , G01N21/6456 , G01N21/6486
摘要： A luminescence imaging installation is disclosed comprising a lightproof enclosure containing: a support receiving a sample to be imaged; a detector detecting a luminescence image from the sample to be imaged; and a light reflector device reflecting light towards the detector The light reflector device surrounds the support at least in part and presents at least two portions that are inclined relative to each other, each reflecting light towards the detector.
摘要翻译： 公开了一种发光成像装置，其包括防光外壳，其包含：接收待成像样品的支架; 检测来自要成像的样品的发光图像的检测器; 以及将光反射到检测器的光反射器装置。光反射器装置至少部分地围绕支撑件并且呈现相对于彼此倾斜的至少两个部分，每个部分朝向检测器反射光。
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