Pyrvinium For The Treatment of Cancer
    3.
    发明申请
    Pyrvinium For The Treatment of Cancer 审中-公开
    Pyrvinium用于治疗癌症

    公开(公告)号:US20090099062A1

    公开(公告)日:2009-04-16

    申请号:US12129250

    申请日:2008-05-29

    摘要: The present invention concerns a pyrvinium compound or an analog thereof for the treatment of cancers. This compound inhibits Wnt activity in the cells of cancers such as adrenocortical, hepatocellular, hepatoblastoma, malignant melanoma, ovarian, Wilm's tumor, Barrett's esophageal, glioma, bladder, breast, gastric, head & neck, lung cell, mesothelioma, and cervical cancers. The present invention also provides a method for assaying for compounds that alter Wnt pathway activity. Also provided are methods for treating Wnt-related non-cancer disease states.

    摘要翻译: 本发明涉及用于治疗癌症的吡嗪鎓化合物或其类似物。 该化合物抑制癌细胞如肾上腺皮质,肝细胞,肝母细胞瘤,恶性黑素瘤,卵巢癌,威尔姆氏肿瘤,巴雷特氏食管癌,神经胶质瘤,膀胱癌,乳腺癌,胃癌,头颈部癌,肺细胞癌,间皮瘤和子宫颈癌中的Wnt活性。 本发明还提供了用于测定改变Wnt途径活性的化合物的方法。 还提供了用于治疗Wnt相关的非癌症疾病状态的方法。