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公开(公告)号：US10098986B1
公开(公告)日：2018-10-16
申请号：US16009468
申请日：2018-06-15
IPC分类号： A61K9/00 , A61L27/60 , A61L27/38 , A61L27/56 , A61L27/54 , A61L27/48 , A61L27/26 , A61L27/36
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US10149924B1
公开(公告)日：2018-12-11
申请号：US16108155
申请日：2018-08-22
IPC分类号： A61K9/00 , A61L27/60 , A61L27/36 , A61L27/26 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/38
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US10004830B2
公开(公告)日：2018-06-26
申请号：US15485358
申请日：2017-04-12
IPC分类号： A61K9/00 , A61L27/60 , A61L27/56 , A61L27/48 , A61L27/54 , A61L27/36 , A61L27/26 , A61L27/38
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US20180147324A1
公开(公告)日：2018-05-31
申请号：US15485358
申请日：2017-04-12
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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5.发明申请公开(公告)号：US20180353655A1
公开(公告)日：2018-12-13
申请号：US16108155
申请日：2018-08-22
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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6.发明申请公开(公告)号：US20180289865A1
公开(公告)日：2018-10-11
申请号：US16009468
申请日：2018-06-15
IPC分类号： A61L27/60 , A61L27/38 , A61L27/56 , A61L27/54 , A61L27/36 , A61L27/26 , A61L27/48 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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