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公开(公告)号：US10098986B1
公开(公告)日：2018-10-16
申请号：US16009468
申请日：2018-06-15
IPC分类号： A61K9/00 , A61L27/60 , A61L27/38 , A61L27/56 , A61L27/54 , A61L27/48 , A61L27/26 , A61L27/36
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US10149924B1
公开(公告)日：2018-12-11
申请号：US16108155
申请日：2018-08-22
IPC分类号： A61K9/00 , A61L27/60 , A61L27/36 , A61L27/26 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/38
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US10004830B2
公开(公告)日：2018-06-26
申请号：US15485358
申请日：2017-04-12
IPC分类号： A61K9/00 , A61L27/60 , A61L27/56 , A61L27/48 , A61L27/54 , A61L27/36 , A61L27/26 , A61L27/38
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US20170224867A1
公开(公告)日：2017-08-10
申请号：US15081202
申请日：2016-03-25
CPC分类号： A61L24/0036 , A61F13/2005 , A61F13/2017 , A61F13/2074 , A61F13/2082 , A61F13/36 , A61F2013/2014 , A61L24/0015 , A61L24/0042 , A61L24/043 , C08J2207/10
摘要： The invention relates to porous absorbent Composite Material, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides a hydrophilic Self-Dispersive, fragmentable and Bio-Absorbable Porous Composite foams, suitable for packing antrum or other cavities of the body, comprising of composite of polymers, which polymer preferably comprises —C(O)—O—; NH2/3+; —OH; —CH2OCH2C(O)O— groups as functional or —CH—O— (e.g. C2H4O; C6H10O5; C6H8O6); —CH—N—O— (e.g. C8H13NO5); O—C—C— (e.g. O—CH2-CH2); —C(O)N— groups in the backbone of the polymers e.g. gelatin, chitosan, collagen, alginate, polyvinyl alcohol, polyethylene glycol, keratin, cellulose.
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5.发明申请公开(公告)号：US20180369315A1
公开(公告)日：2018-12-27
申请号：US16115695
申请日：2018-08-29
IPC分类号： A61K36/9066 , A61F13/00 , A61L15/58 , A61L15/44 , A61L15/42 , A61L15/40 , A61L15/32 , A61L15/22 , A61L15/20 , A61L15/18 , A61K47/36 , A61K47/34 , A61K47/32 , A61K47/22 , A61K47/10 , A61K36/886 , A61K36/82 , A61K36/47 , A61K36/185 , A61K33/38 , A61K31/765 , A61K9/70
CPC分类号： A61K36/9066 , A61F13/00012 , A61F13/00017 , A61F2013/00638 , A61F2013/00646 , A61F2013/0091 , A61K9/7069 , A61K31/765 , A61K33/38 , A61K36/185 , A61K36/47 , A61K36/82 , A61K36/886 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61K2236/33 , A61K2236/51 , A61K2236/53 , A61L15/18 , A61L15/20 , A61L15/225 , A61L15/32 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/585 , A61L2300/104 , A61L2300/30 , A61L2300/404 , A61L2300/62 , A61L2300/802 , A61K2300/00
摘要： This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
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6.发明申请公开(公告)号：US20180353655A1
公开(公告)日：2018-12-13
申请号：US16108155
申请日：2018-08-22
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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7.发明申请公开(公告)号：US20180289865A1
公开(公告)日：2018-10-11
申请号：US16009468
申请日：2018-06-15
IPC分类号： A61L27/60 , A61L27/38 , A61L27/56 , A61L27/54 , A61L27/36 , A61L27/26 , A61L27/48 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.
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公开(公告)号：US10076552B2
公开(公告)日：2018-09-18
申请号：US15384383
申请日：2016-12-20
IPC分类号： A61K36/9066 , A61K36/886 , A61K36/82 , A61F13/00 , A61K36/47 , A61K33/38 , A61K9/70 , A61K31/765 , A61K36/185 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61L15/18 , A61L15/20 , A61L15/22 , A61L15/40 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/32
CPC分类号： A61K36/9066 , A61F13/00012 , A61F13/00017 , A61F2013/00638 , A61F2013/00646 , A61F2013/0091 , A61K9/7069 , A61K31/765 , A61K33/38 , A61K36/185 , A61K36/47 , A61K36/82 , A61K36/886 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61K2236/33 , A61K2236/51 , A61K2236/53 , A61L15/18 , A61L15/20 , A61L15/225 , A61L15/32 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/585 , A61L2300/104 , A61L2300/30 , A61L2300/404 , A61L2300/62 , A61L2300/802 , A61K2300/00
摘要： This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
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公开(公告)号：US10561701B2
公开(公告)日：2020-02-18
申请号：US16115695
申请日：2018-08-29
IPC分类号： A61K36/9066 , A61K36/886 , A61K36/47 , A61K33/38 , A61K36/82 , A61F13/00 , A61K9/70 , A61K31/765 , A61K36/185 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61L15/18 , A61L15/20 , A61L15/22 , A61L15/40 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/32
摘要： This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.
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公开(公告)号：US10293075B2
公开(公告)日：2019-05-21
申请号：US15081202
申请日：2016-03-25
摘要： The invention relates to porous absorbent Composite Material, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides a hydrophilic Self-Dispersive, fragmentable and Bio-Absorbable Porous Composite foams, suitable for packing antrum or other cavities of the body, comprising of composite of polymers, which polymer preferably comprises —C(O)—O—; NH2/3+; —OH; —CH2OCH2C(O)O— groups as functional or —CH—O— (e.g. C2H4O; C6H10O5; C6H8O6); —CH—N—O— (e.g. C8H13NO5); O—C—C— (e.g. O—CH2-CH2); —C(O)N— groups in the backbone of the polymers e.g. gelatin, chitosan, collagen, alginate, polyvinyl alcohol, polyethylene glycol, keratin, cellulose.
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