公开(公告)号：US07378388B2

公开(公告)日：2008-05-27

申请号：US11243619

申请日：2005-10-05

申请人： David B. Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

发明人： David B. Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

IPC分类号： A01N37/00 ,  A61K38/00

CPC分类号： A61K31/352 ,  A61K38/185 ,  G01N33/74 ,  G01N2500/10

摘要： Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.

摘要翻译： 提供了方法和试剂盒，用于操纵和预测女性受试者的生殖能力。 内源性神经营养因子的存在和外源性神经营养因子，特别是BDNF，NT-4/5和NGF的添加通过结合卵母细胞上的受体并刺激卵母细胞的成熟来增加女性患者的生殖能力。 拮抗剂的施用作为避孕药，因为拮抗剂可防止神经营养蛋白结合卵母细胞受体。 神经营养蛋白也可用于在体外刺激卵母细胞的成熟。

公开(公告)号：US07097984B2

公开(公告)日：2006-08-29

申请号：US10209779

申请日：2002-07-31

申请人： David B Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

发明人： David B Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

IPC分类号： G01N33/53 ,  G01N33/533 ,  G01N33/534

CPC分类号： A61K31/352 ,  A61K38/185 ,  G01N33/74 ,  G01N2500/10

摘要： Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.

公开(公告)号：US20060088884A1

公开(公告)日：2006-04-27

申请号：US11243619

申请日：2005-10-05

申请人： David Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

发明人： David Seifer ,  Robert Shelden ,  Bo Feng ,  Cheryl Dreyfus

IPC分类号： A61K38/18 ,  G01N33/53

CPC分类号： A61K31/352 ,  A61K38/185 ,  G01N33/74 ,  G01N2500/10

摘要： Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.