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    Methods of inducing mucosal immunity
    3.
    发明授权
    Methods of inducing mucosal immunity 失效
    诱导粘膜免疫的方法

    公开(公告)号：US06348449B1

    公开(公告)日：2002-02-19

    申请号：US08357398

    申请日：1994-12-16

    申请人： David B. Weiner ,  Bin Wang ,  Kenneth E. Ugen

    发明人： David B. Weiner ,  Bin Wang ,  Kenneth E. Ugen

    IPC分类号： A01N4304

    CPC分类号： A61K31/7052 ,  A61K31/711 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/292 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/541 ,  C07K14/005 ,  C12N15/87 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/13022 ,  C12N2740/13034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2770/24222

    摘要： Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize an individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively.

    摘要翻译： 公开了在个体中针对蛋白质和肽诱导粘膜免疫的方法。 所述方法包括向局部或通过灌洗施用选自直肠，阴道，尿道，舌下和颊部的粘膜组织的步骤，所述核酸分子包含编码蛋白质或肽的核苷酸序列，所述核苷酸序列包含针对 需要哪种粘膜免疫。 可以使用这些方法来免疫个体免受病原体感染，过度增殖性疾病或自身免疫性疾病的使用，该核酸分子编码分别与参与过度增殖性疾病或自身免疫性疾病的细胞相关的病原体抗原或蛋白质共享表位的蛋白质和肽 。

    Method for the treatment of malignancies
    4.
    发明授权
    Method for the treatment of malignancies 有权
    恶性肿瘤治疗方法

    公开(公告)号：US08927518B1

    公开(公告)日：2015-01-06

    申请号：US13969078

    申请日：2013-08-16

    申请人： Richard Heller ,  Kenneth E. Ugen

    发明人： Richard Heller ,  Kenneth E. Ugen

    IPC分类号： A61K48/00 ,  C12N15/87 ,  A61N1/32

    CPC分类号： A61K48/0083 ,  A61K38/00 ,  A61K48/005 ,  A61N1/327 ,  C07K14/70532

    摘要： A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four days between the first and second treatments and a time of three days between the second and third treatments. It was found that the intratumor treatments using electroporation not only resulted in tumor regression but also induced an immune memory response which prevented the formation of new tumors.

    摘要翻译： 本文提供了治疗癌性肿瘤的方法。 该方法包括将有效剂量的针对IL-12，B7-1或IL-15编码的质粒注入癌性肿瘤中，随后向肿瘤施用至少一个高电压，短持续时间的脉冲。 电穿孔脉冲可以在至少700V / cm下施用持续时间小于1毫秒。 用电穿孔进行肿瘤内治疗可以以至少两种治疗方案施用，治疗之间的时间为约7天。 电穿孔的瘤内治疗可以在三次治疗方案中进行，在第一次和第二次治疗之间四天的时间和第二次和第三次治疗之间的三天的时间。 发现使用电穿孔的肿瘤内治疗不仅导致肿瘤消退，而且诱导免疫记忆反应，其阻止新肿瘤的形成。