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    Piperazine derivatives, their preparation and uses in therapy
    7.
    发明授权
    Piperazine derivatives, their preparation and uses in therapy 失效

    公开(公告)号：US07109201B2

    公开(公告)日：2006-09-19

    申请号：US10471433

    申请日：2002-03-11

    申请人： Mervyn Thompson ,  Paul Adrian Wyman

    发明人： Mervyn Thompson ,  Paul Adrian Wyman

    IPC分类号： A61K31/496 ,  C07D403/04 ,  C07D401/14

    CPC分类号： C07D401/10 ,  C07D209/08

    摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed: in which Ra is a group of formula (i) wherein P2 is phenyl, naphthyl, heteroaryl or a 5 to 7 membered heterocyclic ring; P3 is phenyl, naphthyl or heteroaryl; R1 is NR4COR5, NR4SO2R5, CH2NR4SO2R5, CH2NR4COR5 or CH2NR4CO2R5 where R4 and R5 are independently hydrogen or C1-6alkyl; R2 and R3 are independently halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, COC1-6alkyl, haloC1-6alkyl, cyano or NR6R7 where R6 and R7 are independently hydrogen or C1-6alkyl; b and c are independently 0, 1, 2 or 3; Y is a single bond, CH2 or NH; W is —(CR9R10)t—where t is 2, 3 or 4 and R9 and R10 are independently hydrogen or C1-6alkyl or W is a group CH═CH; Rb is hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, COC1-6alkyl, cyano or C1-6alkoxy; and Rc is hydrogen or C1-6alkyl. Processes for preparation of the compounds and their uses in therapy, particularly depression, are also disclosed.