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    Novel compounds
    5.
    发明申请
    Novel compounds 失效
    新型化合物

    公开(公告)号：US20060235030A1

    公开(公告)日：2006-10-19

    申请号：US11389112

    申请日：2006-03-24

    Applicant: James Callahan ,  Zehong Wan ,  Hongxing Yan

    Inventor： James Callahan ,  Zehong Wan ,  Hongxing Yan

    IPC: A61K31/519 ,  C07D487/02

    CPC classification number: C07D487/04

    Abstract: Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

    Abstract translation: 新型取代的1,5,7-三取代-3,4-二氢嘧啶并[4,5-d]嘧啶-2-（1H） - 酮化合物及其组合物及其在CSBP / RK / p38激酶抑制剂治疗中的用途 。

    Nf-kb inhibitors
    7.
    发明申请
    Nf-kb inhibitors 失效
    Nf-kb抑制剂

    公开(公告)号：US20060058371A1

    公开(公告)日：2006-03-16

    申请号：US10517111

    申请日：2003-05-29

    Applicant: James Callahan ,  Zehong Wan

    Inventor： James Callahan ,  Zehong Wan

    IPC: A61K31/381 ,  C07D327/08

    CPC classification number: C07D333/68

    Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in which diseases excessive activation of NF-κB is implicated.

    Abstract translation: 本发明提供了使用它们用IkappaB的IKK-β磷酸化的氨基噻吩抑制剂治疗疾病的新型化合物和方法。 在这样做时，这些氨基噻吩抑制剂阻断转录因子NF-κB的病理活化，其中涉及NF-κB过度激活的疾病。

    Dual tone multiple frequency generator
    8.
    发明授权
    Dual tone multiple frequency generator 失效
    双音多频发生器

    公开(公告)号：US4061886A

    公开(公告)日：1977-12-06

    申请号：US617955

    申请日：1975-09-29

    Applicant: Michael James Callahan, Jr. ,  Gordon Bates Hoffman

    Inventor： Michael James Callahan, Jr. ,  Gordon Bates Hoffman

    IPC: H03B11/00 ,  H03B28/00 ,  H03L7/18 ,  H04L27/26 ,  H04M1/50 ,  H04M1/26

    CPC classification number: H04M1/505

    Abstract: A dual-tone multiple frequency signal generator is provided for use with telecommunications systems, data transfer systems and other applications. The tone encoding system utilizes MOS/LSI integrated circuitry on a single chip powered directly by telephone line voltages. An electronic keyboard circuit provides synchronized pulses to decode single-pole, single-throw keyboard switches by row and column. A crystal-controlled oscillator generates a reference frequency which is divided according to the row and column of an activated keyboard switch to obtain two pulse signals having frequencies representative of the activated switch. The outputs of the divider circuitry are fed to programmed logic array which generates two digitally coded signals each representing a sinusoidal waveform. A digital-to-analog ladder network converts the digitally coded signals to continuous sine waves, and an operational amplifier combines the sinusoidal waveforms to provide a dual-tone output. The integrated circuitry also utilizes electronic switches for the common functions of tone transmission, including applying power to the oscillator, disconnecting the audio transmitter and attenuating the input to the receiver. Complementary-symmetry, metal-oxide semi-conductor elements implement the circuitry design with bi-polar transistors on the same chip performing some of the common function switching.

    Abstract translation: 提供双音多频信号发生器用于电信系统，数据传输系统和其他应用。 音调编码系统在直接由电话线电压供电的单个芯片上使用MOS / LSI集成电路。 电子键盘电路提供同步脉冲，通过行和列解码单刀单掷键盘开关。 晶体振荡器产生根据激活的键盘开关的行和列分割的参考频率，以获得具有表示激活的开关的频率的两个脉冲信号。 分频器电路的输出被馈送到编程逻辑阵列，其产生每个表示正弦波形的两个数字编码信号。 数模转换梯形网将数字编码信号转换为连续正弦波，运算放大器组合正弦波形以提供双音输出。 集成电路还利用电子开关用于音调传输的共同功能，包括向振荡器施加电力，断开音频发射器并衰减到接收机的输入。 互补对称，金属氧化物半导体元件在同一芯片上实现具有双极晶体管的电路设计，执行一些通用功能切换。

    Protection for bi-directional switch
    9.
    发明授权
    Protection for bi-directional switch 有权
    保护双向开关

    公开(公告)号：US08248747B2

    公开(公告)日：2012-08-21

    申请号：US12627729

    申请日：2009-11-30

    Applicant: Michael James Callahan, Jr.

    Inventor： Michael James Callahan, Jr.

    IPC: H02H3/08 ,  H02H9/02

    CPC classification number: G01R19/16571 ,  H03K17/0826

    Abstract: A bi-directional protection circuit employs a single comparator for detecting fault conditions. Diodes are coupled between a detection node and voltage dividers setting references for inverting and non-inverting comparator inputs, each diode forward biased during one of the positive and negative halves of the alternating current input signal cycle and coupling the detection node to a respective one of the inverting and non-inverting comparator inputs, and reverse biased during the other of the positive and negative halves and decoupling the detection node from the other of the inverting and non-inverting comparator inputs. Upon an overcurrent condition during the positive half, a voltage at the inverting comparator input is drawn above the reference voltage at the non-inverting input. Upon an overcurrent condition during the negative half, a voltage at the non-inverting comparator input is drawn below the reference voltage at the inverting input.

    Abstract translation: 双向保护电路采用单个比较器来检测故障状况。 二极管耦合在检测节点和分压器之间，用于设置反相和非反相比较器输入的参考值，每个二极管在交流输入信号周期的正半周和负半周期期间正向偏置，并将检测节点耦合到 反相和非反相比较器输入，并在正半周和负半周中的另一个反向偏置，并将检测节点与反相和非反相比较器输入中的另一个去耦。 在正半周期的过电流条件下，反相比较器输入端的电压在非反相输入端上被吸引到基准电压之上。 在负半周期的过电流条件下，非反相比较器输入端的电压被拉低到反相输入端的参考电压以下。

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