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公开(公告)号：US20060009412A1
公开(公告)日：2006-01-12
申请号：US11230995
申请日：2005-09-19
IPC分类号： A61K48/00
CPC分类号： C12N9/12 , A61K38/00 , A61K48/00 , C12N2799/021
摘要： The present invention describes methods for modulating angiogenesis in tissues using Src protein, modified Src protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Src protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Src protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Src protein, or modified forms thereof.
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公开(公告)号：US20060258686A1
公开(公告)日：2006-11-16
申请号：US10535325
申请日：2003-11-18
申请人： David Cheresh , Robert Paul , Brian Eliceiri
发明人： David Cheresh , Robert Paul , Brian Eliceiri
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A01K67/0271 , A61K38/45 , A61K48/00
摘要： Myocardial infarction in a mammal is treated by administering to the mammal a therapeutically effective amount of a chemical Src family tyrosine kinase protein inhibitor and the use of such inhibitor compounds for the preparation of a medicament for treating myocardial infarction. Myocardial infarction can be prevented by administering to the mammal a prophylactic amount of the inhibitor. The inhibitor preferably is an inhibitor of Src protein selected from the group consisting of a pyrazolopyrimidine class Src family tyrosine kinase inhibitor, a macrocyclic dienone class Src family tyrosine kinase inhibitor, a pyrido[2,3-d]pyrimidine class Src family tyrosine kinase inhibitor, a 4-anilino-3-quinolinecarbonitrile class Src family tyrosine kinase inhibitor, and a mixture thereof. The Src family tyrosine kinase inhibitors can be used to prepare medicaments for the treatment of myocardial infarction. Also disclosed are articles of manufacture containing a chemical Src family tyrosine kinase inhibitor.
摘要翻译： 通过向哺乳动物施用治疗有效量的化学品Src家族酪氨酸激酶蛋白抑制剂和这种抑制剂化合物用于制备用于治疗心肌梗塞的药物的用途来治疗哺乳动物的心肌梗死。 可以通过向哺乳动物施用预防量的抑制剂来防止心肌梗死。 抑制剂优选是Src蛋白的抑制剂，其选自吡唑并嘧啶类Src家族酪氨酸激酶抑制剂，大环二烯酮类Src家族酪氨酸激酶抑制剂，吡啶并[2,3-d]嘧啶类Src家族酪氨酸激酶抑制剂 ，4-苯胺基-3-喹啉甲腈类Src家族酪氨酸激酶抑制剂及其混合物。 Src家族酪氨酸激酶抑制剂可用于制备用于治疗心肌梗死的药物。 还公开了含有化学Src家族酪氨酸激酶抑制剂的制品。
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3.发明申请Methods and compositions useful for modulation of angiogenesis using protein kinase Raf and Ras 审中-公开使用蛋白激酶Raf和Ras调节血管发生的方法和组合物公开(公告)号：US20060040853A1
公开(公告)日：2006-02-23
申请号：US11219264
申请日：2005-09-02
申请人： John Hood , Brian Eliceiri , David Cheresh
发明人： John Hood , Brian Eliceiri , David Cheresh
摘要： The present invention describes methods for modulating angiogenesis in tissues using Raf and/or Ras protein, modified Raf or Ras protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Raf and/or Ras protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Raf and/or Ras protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Raf or Ras protein, or modified forms thereof.
摘要翻译： 本发明描述了使用Raf和/或Ras蛋白，修饰的Raf或Ras蛋白调节组织中血管生成的方法，以及编码这种方法的核酸。 特别地，本发明描述了使用非活性Raf和/或Ras蛋白质或其编码的核酸抑制血管生成或使用活性Raf和/或Ras蛋白质或其编码的核酸来增强血管生成的方法。 本发明还描述了基因递送系统用于提供编码Raf或Ras蛋白质的核酸或其修饰形式的用途。
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4.发明授权Methods and compositions useful for modulation of angiogenesis using tyrosine kinase Src 失效使用酪氨酸激酶Src调节血管发生的方法和组合物公开(公告)号：US07585841B2
公开(公告)日：2009-09-08
申请号：US11230995
申请日：2005-09-19
IPC分类号： A61K38/00
CPC分类号： C12N9/12 , A61K38/00 , A61K48/00 , C12N2799/021
摘要： The present invention describes methods for modulating angiogenesis in tissues using Src protein, modified Src protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Src protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Src protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Src protein, or modified forms thereof.
摘要翻译： 本发明描述了使用Src蛋白质，修饰的Src蛋白质和编码这种蛋白质的核酸调节组织中血管生成的方法。 特别地，本发明描述了使用无活性Src蛋白或其编码的核酸抑制血管生成或使用活性Src蛋白增强血管发生或编码其的核酸抑制血管发生的方法。 本发明还描述了使用基因递送系统提供编码Src蛋白的核酸或其修饰形式。
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5.发明授权Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases 有权用于调节血管生成和血管通透性的方法和组合物使用SRC或是酪氨酸激酶公开(公告)号：US06685938B1
公开(公告)日：2004-02-03
申请号：US09470881
申请日：1999-12-22
申请人： David A. Cheresh , Brian Eliceiri
发明人： David A. Cheresh , Brian Eliceiri
IPC分类号： A61K3845
CPC分类号： A61K38/45 , A01K67/0271 , A61K48/00 , C12N9/12 , C12N2799/021
摘要： The present invention describes methods for modulating vascular permeability (VP) in tissues using Src or modified Src protein, Yes protein or modified Yes protein, or mixtures thereof, and nucleic acids capable of expression such proteins. In particular, the invention describes methods for inhibiting VP using an inactive Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor, or for potentiating VP using an active, Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor. Related compositions and articles of manufacture are also disclosed.
摘要翻译： 本发明描述了使用Src或修饰的Src蛋白质，Yes蛋白质或修饰的Yes蛋白质或其混合物以及能够表达这种蛋白质的核酸调节组织中血管通透性（VP）的方法。 特别地，本发明描述了使用无活性Src或Yes蛋白质或其混合物或其编码的核酸抑制VP或使用活性，Src或Yes蛋白质或其混合物或其编码的核酸来增强VP的方法 。 还公开了相关的组合物和制品。
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公开(公告)号：US20080200481A1
公开(公告)日：2008-08-21
申请号：US12148001
申请日：2008-04-16
申请人： David A. Cheresh , Robert Paul , Brian Eliceiri
发明人： David A. Cheresh , Robert Paul , Brian Eliceiri
IPC分类号： A61K31/519 , A61P9/10
CPC分类号： A61K31/519 , A01K67/0271 , A61K38/45 , A61K48/00
摘要： Myocardial infarction in a mammal is treated by administering to the mammal a therapeutically effective amount of a chemical Src family tyrosine kinase protein inhibitor and the use of such inhibitor compounds for the preparation of a medicament for treating myocardial infarction. Myocardial infarction can be prevented by administering to the mammal a prophylactic amount of the inhibitor. The inhibitor preferably is an inhibitor of Src protein selected from the group consisting of a pyrazolopyrimidine class Src family tyrosine kinase inhibitor, a macrocyclic dienone class Src family tyrosine kinase inhibitor, a pyrido[2,3-d]pyrimidine class Src family tyrosine kinase inhibitor, a 4-anilino-3-quinolinecarbonitrile class Src family tyrosine kinase inhibitor, and a mixture thereof. The Src family tyrosine kinase inhibitors can be used to prepare medicaments for the treatment of myocardial infarction. Also disclosed are articles of manufacture containing a chemical Src family tyrosine kinase inhibitor.
摘要翻译： 通过向哺乳动物施用治疗有效量的化学品Src家族酪氨酸激酶蛋白抑制剂和这种抑制剂化合物用于制备用于治疗心肌梗塞的药物的用途来治疗哺乳动物的心肌梗死。 可以通过向哺乳动物施用预防量的抑制剂来防止心肌梗死。 抑制剂优选是Src蛋白的抑制剂，其选自吡唑并嘧啶类Src家族酪氨酸激酶抑制剂，大环二烯酮类Src家族酪氨酸激酶抑制剂，吡啶并[2,3-d]嘧啶类Src家族酪氨酸激酶抑制剂 ，4-苯胺基-3-喹啉甲腈类Src家族酪氨酸激酶抑制剂及其混合物。 Src家族酪氨酸激酶抑制剂可用于制备用于治疗心肌梗死的药物。 还公开了含有化学Src家族酪氨酸激酶抑制剂的制品。
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