公开(公告)号：US20130225791A1

公开(公告)日：2013-08-29

申请号：US13818569

申请日：2011-08-25

申请人： David E. Reichert ,  Paul J.A. Kenis ,  Tobias D. Wheeler ,  Amit V. Desai ,  Dexing Zeng ,  Birce C. Önal

发明人： David E. Reichert ,  Paul J.A. Kenis ,  Tobias D. Wheeler ,  Amit V. Desai ,  Dexing Zeng ,  Birce C. Önal

IPC分类号： C07K1/13 ,  C07K1/107 ,  C07B59/00 ,  B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00889 ,  C07B59/00 ,  C07B59/008 ,  C07K1/1077 ,  C07K1/13

摘要： A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

公开(公告)号：US20080121045A1

公开(公告)日：2008-05-29

申请号：US11564779

申请日：2006-11-29

申请人： Matthew C. Cole ,  Paul J.A. Kenis

发明人： Matthew C. Cole ,  Paul J.A. Kenis

IPC分类号： G01F1/56

CPC分类号： G01N27/226 ,  B01L3/5027 ,  G01N27/12 ,  G01N27/22

摘要： A sensor array includes a plurality of q sensors, a common output lead electrically connected to each sensor, a plurality of m primary input leads each primary input lead electrically connected to n of the plurality of sensors, and a plurality of n secondary input leads each secondary input lead electrically connected to m of the plurality of sensors. The number of sensors q=m·n, m is at least 2, n is at least 2, and each sensor is electrically connected to one of the plurality of primary input leads and one of the plurality of secondary input leads.

摘要翻译： 传感器阵列包括多个q传感器，电连接到每个传感器的公共输出引线，多个m个主输入引线，每个主输入引线电连接到多个传感器中的n个，以及多个n个次级输入引线 二次输入引线与多个传感器的m电连接。 传感器的数量q = m.n，m至少为2，n至少为2，并且每个传感器电连接到多个主输入引线中的一个和多个辅助输入引线中的一个。