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1.发明申请E.coli host cells with modified phos/psts periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs 有权具有修饰的phos / psts周质磷酸结合蛋白的大肠杆菌宿主细胞，以及重组生产厂的制造方法公开(公告)号：US20070054354A1
公开(公告)日：2007-03-08
申请号：US10531402
申请日：2003-10-15
CPC分类号： C07K14/245 , C12N1/20
摘要： The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type copurify with said recombinant antibody.
摘要翻译： 本发明提供了表达重组抗体的大肠杆菌宿主细胞，其特征在于已将遗传修饰的大肠杆菌宿主细胞改变为野生型与所述重组抗体共培养的一种或多种大肠杆菌蛋白质的至少一种物理性质。
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公开(公告)号：US20060196502A1
公开(公告)日：2006-09-07
申请号：US10545686
申请日：2004-02-13
申请人： Murray Pilcher , Andrew Chapman , Nigel Thomson
发明人： Murray Pilcher , Andrew Chapman , Nigel Thomson
CPC分类号： A61G10/02 , A61G2203/46 , A63B2213/006
摘要： A simulated altitude training system for providing deleted oxygen gas at variable levels for a range of users each user has a predetermined plan and has an individual identifier. The system automatically delivers the correct oxygen level according to the prescribed individual plan. Also provided are alternative embodiments for providing the individualised oxygen level as well as a membrane heating system.
摘要翻译： 一种模拟高度训练系统，用于为每个用户具有预定计划并具有单独标识符的用户范围提供可变水平的缺氧氧气。 系统根据规定的个人计划自动提供正确的氧气含量。 还提供了用于提供个体化氧水平的替代实施例以及膜加热系统。
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公开(公告)号：US08518201B2
公开(公告)日：2013-08-27
申请号：US12799162
申请日：2010-04-20
CPC分类号： E01C3/06
摘要： A tubing with improved compression strength for a subsurface water drainage system comprising a core polymeric support structure wrapped longitudinally in first and second geotextile materials, wherein the core polymeric support structure is heated to soften the polymeric material and wherein the first and second geotextile materials overlap and are adhered together with a hot melt adhesive and tensioned to tightly wrap the core, thereby forming the tubing.
摘要翻译： 一种用于地下排水系统具有改进的压缩强度的管道，其包括在第一和第二土工织物材料中纵向缠绕的芯聚合物支撑结构，其中所述芯聚合物支撑结构被加热以软化聚合材料，并且其中第一和第二土工织物材料重叠 用热熔粘合剂粘合在一起并张紧以紧紧包裹芯，由此形成管。
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公开(公告)号：US20100272513A1
公开(公告)日：2010-10-28
申请号：US12799162
申请日：2010-04-20
CPC分类号： E01C3/06
摘要： A tubing with improved compression strength for a subsurface water drainage system comprising a core polymeric support structure wrapped longitudinally in first and second geotextile materials, wherein the core polymeric support structure is heated to soften the polymeric material and wherein the first and second geotextile materials overlap and are adhered together with a hot melt adhesive and tensioned to tightly wrap the core, thereby forming the tubing.
摘要翻译： 一种用于地下排水系统具有改进的压缩强度的管道，其包括在第一和第二土工织物材料中纵向缠绕的芯聚合物支撑结构，其中所述芯聚合物支撑结构被加热以软化聚合材料，并且其中第一和第二土工织物材料重叠 用热熔粘合剂粘合在一起并张紧以紧紧包裹芯，由此形成管。
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公开(公告)号：US20100212336A1
公开(公告)日：2010-08-26
申请号：US12678906
申请日：2008-09-17
CPC分类号： F25D31/002 , F25C5/12 , F25C5/20 , F25C2301/002 , F25D17/02
摘要： The present invention provides a control system for controlling the ice volume fraction of a circulating ice-containing medium. The control system comprises a freezer apparatus for generating an ice-containing medium, a pump for circulating the ice-containing medium through a flow circuit comprising an outward line, a main line and a return line, and a bypass line connecting the outward line and return line to form a bypass circuit. In use, the time taken for circulating ice-containing medium to pass through the bypass circuit is less than the time taken for circulating ice-containing medium to pass through the flow circuit. The present invention also provides a method for controlling the ice volume fraction of a circulating ice-containing medium using such a control system.
摘要翻译： 本发明提供一种用于控制循环含冰介质的冰体积分数的控制系统。 控制系统包括用于产生含冰介质的冷冻装置，用于使含冰介质循环通过包括外线，主线和返回管线的流动回路的泵，以及连接外部线路和 返回线路形成旁路电路。 在使用中，使含冰介质循环通过旁路回路所花费的时间小于使含冰介质循环通过流路所需的时间。 本发明还提供一种使用这种控制系统来控制循环含冰介质的冰体积分数的方法。
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公开(公告)号：US20090077999A1
公开(公告)日：2009-03-26
申请号：US12224996
申请日：2007-03-05
申请人： Andrew Chapman , Andrew Hillis , Howard Biddle , Jeremy Carey
发明人： Andrew Chapman , Andrew Hillis , Howard Biddle , Jeremy Carey
CPC分类号： F25D31/002 , B67D1/0864 , B67D1/0865 , F25C2301/002
摘要： The present invention relates to a system for cooling a beverage, the system comprising: a beverage line (5) connectable to a beverage supply for transporting beverage from the beverage supply through an insulated carrier to a dispensation site (1), a cooling medium generator (2) for generating a cooling medium; a cooling line (6) for transporting the cooling medium from the cooling medium generator through the insulated carrier so as to allow heat exchange between the cooling medium in the cooling line and the beverage in the beverage line; and a pump (3) for pumping the cooling medium through the cooling line. The cooling medium generator (2) is an ice slush generator. The present invention also relates to a method of cooling a beverage flowing through a beverage line using ice slush as a cooling medium.
摘要翻译： 本发明涉及一种用于冷却饮料的系统，该系统包括：可连接到饮料供应源的饮料生产线（5），用于将饮料从饮料供应通过绝缘载体输送到分配部位（1）;冷却介质发生器 （2），用于产生冷却介质; 冷却管线（6），用于将冷却介质从冷却介质发生器通过绝缘载体输送，以便允许冷却管线中的冷却介质与饮料管线中的饮料之间进行热交换; 以及用于通过冷却管线泵送冷却介质的泵（3）。 冷却介质发生器（2）是冰浆发生器。 本发明还涉及一种使用冰淇淋作为冷却介质来冷却流过饮料管线的饮料的方法。
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公开(公告)号：US20060233800A1
公开(公告)日：2006-10-19
申请号：US11374231
申请日：2006-03-13
申请人： Diljeet Athwal , Derek Brown , Andrew Weir , Andrew Popplewell , Andrew Chapman , David King
发明人： Diljeet Athwal , Derek Brown , Andrew Weir , Andrew Popplewell , Andrew Chapman , David King
IPC分类号： A61K39/395 , C07K16/24 , C07K16/46
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
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公开(公告)号：US08615497B1
公开(公告)日：2013-12-24
申请号：US12005125
申请日：2007-12-19
申请人： Andrew Chapman , David Martin
发明人： Andrew Chapman , David Martin
CPC分类号： H04L63/20 , G06F17/2229 , G06F17/2725 , G06F17/30085 , G06F17/30371
摘要： A record is managed by obtaining from an external system on which a stored object comprising the record is stored a property of the stored object as stored on the external system. A stored property associated with the record is compared with the obtained property of the stored object. In the event the comparison does not match, responsive action is taken.
摘要翻译： 通过从包含记录的存储对象存储存储在外部系统上的存储对象的属性的外部系统获得记录来管理记录。 与记录相关联的存储属性与获取的存储对象的属性进行比较。 如果比较不匹配，则采取响应式措施。
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公开(公告)号：US08418569B2
公开(公告)日：2013-04-16
申请号：US12449570
申请日：2008-04-11
IPC分类号： G01L5/24
CPC分类号： G01L5/0042 , G01L5/24 , G01L25/003
摘要： A variable torque-rate test point for the performance testing of rotary tools for threaded fasteners comprises a screw-threaded bolt (1) having a moment of inertia comparable to that of a bolt to be tightened using the rotary tool. The bolt (1) is tightened in the test joint against a torque-rate adjustment device (6) which can be adjusted to simulate a hard or a soft joint. The adjustment device (6) comprises a washer portion (7) beneath the bolt head (4), at least one spring beam (8) extending from a reaction point (9) radially outwardly of the bolt (1), and a pivotal bearing member (10) or other pivot at a mid portion of the beam (8). The beam (8) flexes as it extends in cantilever over the pivot point, and that flexure can be adjusted to vary the torque-rate of the test joint by varying the distance between the pivot point and the rotary axis of the bolt (1).
摘要翻译： 用于螺纹紧固件的旋转工具的性能测试的可变扭矩率测试点包括螺旋螺栓（1），其具有与使用旋转工具紧固的螺栓的惯性矩相当的惯性矩。 螺栓（1）在测试接头中被紧固在扭矩调节装置（6）上，扭矩调节装置（6）可被调节以模拟硬接头或软接头。 调节装置（6）包括在螺栓头（4）下方的垫圈部分（7），从螺栓（1）的径向向外的反应点（9）延伸的至少一个弹簧梁（8）和枢转轴承 构件（10）或其他枢轴在梁（8）的中部。 梁（8）随着悬臂在枢轴点上的延伸而弯曲，并且可以通过改变枢轴点和螺栓（1）的旋转轴线之间的距离来调整弯曲以改变测试接头的扭矩率， 。
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公开(公告)号：US20100132481A1
公开(公告)日：2010-06-03
申请号：US12449570
申请日：2008-04-11
IPC分类号： G01L5/24
CPC分类号： G01L5/0042 , G01L5/24 , G01L25/003
摘要： A variable torque-rate test point for the performance testing of rotary tools for threaded fasteners comprises a screw-threaded bolt (1) having a moment of inertia comparable to that of a bolt to be tightened using the rotary tool. The bolt (1) is tightened in the test joint against a torque-rate adjustment device (6) which can be adjusted to simulate a hard or a soft joint. The adjustment device (6) comprises a washer portion (7) beneath the bolt head (4), at least one spring beam (8) extending from a reaction point (9) radially outwardly of the bolt (1), and a pivotal bearing member (10) or other pivot means at a mid portion of the beam (8). The beam (8) flexes as it extends in cantilever over the pivot point, and that flexure can be adjusted to vary the torque-rate of the test joint by varying the distance between the pivot point and the rotary axis of the bolt (1).
摘要翻译： 用于螺纹紧固件的旋转工具的性能测试的可变扭矩率测试点包括螺旋螺栓（1），其具有与使用旋转工具紧固的螺栓的惯性矩相当的惯性矩。 螺栓（1）在测试接头中被紧固在扭矩调节装置（6）上，扭矩调节装置（6）可被调节以模拟硬接头或软接头。 调节装置（6）包括在螺栓头（4）下方的垫圈部分（7），从螺栓（1）的径向向外的反应点（9）延伸的至少一个弹簧梁（8）和枢转轴承 构件（10）或其他枢转装置在梁（8）的中部。 梁（8）随着悬臂在枢轴点上的延伸而弯曲，并且可以通过改变枢轴点和螺栓（1）的旋转轴线之间的距离来调整弯曲以改变测试接头的扭矩速率， 。
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