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![Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors](/abs-image/US/2014/04/29/US08710057B2/abs.jpg.150x150.jpg)
1.发明授权Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors 有权咪唑并[1,2-B]吡嗪和吡唑并[1,5-A]吡啶衍生物及其作为蛋白激酶抑制剂的用途公开(公告)号：US08710057B2
公开(公告)日：2014-04-29
申请号：US13188195
申请日：2011-07-21
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
摘要翻译： 本发明提供包含以下结构（I）和（II）的咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂：或其立体异构体，前药或药学上可接受的盐 其中R，R 1，R 2和X如本文所定义。 还公开了用于治疗癌症和其它Pim激酶相关病症的组合物和方法。
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![Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors](/abs-image/US/2010/07/06/US07750007B2/abs.jpg.150x150.jpg)
2.发明授权Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors 有权咪唑并[1,2-β]哒嗪和吡唑并[1,5-a]嘧啶衍生物及其作为蛋白激酶抑制剂的用途公开(公告)号：US07750007B2
公开(公告)日：2010-07-06
申请号：US11935959
申请日：2007-11-06
IPC分类号： A61K31/5025 , A61K31/519 , C07D413/12 , C07D487/04 , A61K31/5375 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
摘要翻译： 本发明提供包含以下结构（I）和（II）的咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂：或其立体异构体，前药或药学上可接受的盐 其中R，R 1，R 2和X如本文所定义。 还公开了用于治疗癌症和其它Pim激酶相关病症的组合物和方法。
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![IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](/abs-image/US/2010/09/09/US20100227861A1/abs.jpg.150x150.jpg)
3.发明申请IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS 审中-公开咪唑并[1,2-β]吡嗪和吡唑并[1,5-α]吡啶衍生物及其作为蛋白激酶抑制剂的用途公开(公告)号：US20100227861A1
公开(公告)日：2010-09-09
申请号：US12785322
申请日：2010-05-21
IPC分类号： A61K31/5377 , A61K31/5025 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
摘要翻译： 本发明提供包含以下结构（I）和（II）的咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂：或其立体异构体，前药或药学上可接受的盐 其中R，R 1，R 2和X如本文所定义。 还公开了用于治疗癌症和其它Pim激酶相关病症的组合物和方法。
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![IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](/abs-image/US/2008/10/23/US20080261988A1/abs.jpg.150x150.jpg)
4.发明申请IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS 有权咪唑并[1,2-β]吡嗪和吡唑并[1,5-α]吡啶衍生物及其作为蛋白激酶抑制剂的用途公开(公告)号：US20080261988A1
公开(公告)日：2008-10-23
申请号：US11935959
申请日：2007-11-06
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
摘要翻译： 本发明提供包含以下结构（I）和（II）的咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂：或其立体异构体，前药或药学上可接受的盐 其中R，R 1，R 2和X如本文所定义。 还公开了用于治疗癌症和其它Pim激酶相关病症的组合物和方法。
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![IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](/abs-image/US/2011/11/17/US20110281863A1/abs.jpg.150x150.jpg)
5.发明申请IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS 有权咪唑并[1,2-B]吡嗪和吡唑并[1,5-A]吡啶衍生物及其作为蛋白激酶抑制剂的用途公开(公告)号：US20110281863A1
公开(公告)日：2011-11-17
申请号：US13188195
申请日：2011-07-21
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/519 , C07D487/04 , A61K31/5025 , A61K31/496
CPC分类号： C07D487/04
摘要： The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
摘要翻译： 本发明提供包含以下结构（I）和（II）的咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂：或其立体异构体，前药或药学上可接受的盐 其中R，R 1，R 2和X如本文所定义。 还公开了用于治疗癌症和其它Pim激酶相关病症的组合物和方法。
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6.发明授权Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same 有权包含蛋白激酶抑制剂的盐的药物制剂及其使用方法公开(公告)号：US08445502B2
公开(公告)日：2013-05-21
申请号：US12906640
申请日：2010-10-18
申请人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
发明人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , A61K31/7048 , A61K33/24 , A61K45/06 , C07D491/048 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
摘要翻译： 本发明涉及包含蛋白激酶抑制剂MP470的药物制剂，以及用于治疗涉及不期望的细胞增殖的病症如癌症的方法。
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7.发明申请PHARMACEUTICAL FORMULATIONS COMPRISING SALTS OF A PROTEIN KINASE INHIBITOR AND METHODS OF USING SAME 有权包含蛋白激酶抑制剂的盐的药物制剂及其使用方法公开(公告)号：US20110086112A1
公开(公告)日：2011-04-14
申请号：US12906640
申请日：2010-10-18
申请人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
发明人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
IPC分类号： A61K33/24 , C07D471/04 , A61K31/496 , A61P35/00
CPC分类号： A61K31/519 , A61K31/7048 , A61K33/24 , A61K45/06 , C07D491/048 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
摘要翻译： 本发明涉及包含蛋白激酶抑制剂MP470的药物制剂，以及用于治疗涉及不期望的细胞增殖的病症如癌症的方法。
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8.发明授权Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same 有权包含蛋白激酶抑制剂的盐的药物制剂及其使用方法公开(公告)号：US07820684B2
公开(公告)日：2010-10-26
申请号：US12041565
申请日：2008-03-03
申请人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
发明人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , A61K31/7048 , A61K33/24 , A61K45/06 , C07D491/048 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
摘要翻译： 本发明涉及包含蛋白激酶抑制剂MP470的药物制剂，以及用于治疗涉及不期望的细胞增殖的病症如癌症的方法。
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9.发明申请PHARMACEUTICAL FORMULATIONS COMPRISING SALTS OF A PROTEIN KINASE INHIBITOR AND METHODS OF USING SAME 有权包含蛋白激酶抑制剂的盐的药物制剂及其使用方法公开(公告)号：US20080226747A1
公开(公告)日：2008-09-18
申请号：US12041565
申请日：2008-03-03
申请人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
发明人： David J. Bearss , Rajashree Joshi-Hangal , Xiao-Hui Liu , Pasit Phiasivongsa , Sanjeev G. Redkar , Hariprasad Vankayalapati
IPC分类号： A61K31/519 , C07D491/048 , A61P35/00 , A61K33/24 , A61K31/7048
CPC分类号： A61K31/519 , A61K31/7048 , A61K33/24 , A61K45/06 , C07D491/048 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
摘要翻译： 本发明涉及包含蛋白激酶抑制剂MP470的药物制剂，以及用于治疗涉及不期望的细胞增殖的病症如癌症的方法。
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10.发明申请PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS JAK2 KINASE INHIBITORS 审中-公开吡嗪-2,4-二胺衍生物及其作为JAK2激酶抑制剂的用途公开(公告)号：US20080214558A1
公开(公告)日：2008-09-04
申请号：US12040002
申请日：2008-02-29
IPC分类号： A61K31/505 , C07D239/48 , C07D403/12 , C07D401/14 , A61K31/496 , A61P35/02 , A61P35/00
CPC分类号： C07D239/48 , C07D295/088 , C07D295/135 , C07D401/12
摘要： Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.
摘要翻译： 公开了具有作为JAK2激酶抑制剂的活性的嘧啶-2,4-二胺衍生物，以及用于治疗癌症和其它JAK2激酶相关病症的药物组合物和方法。
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