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    Imidazopyridayine derivatives having antiviral activity
    1.
    发明授权
    Imidazopyridayine derivatives having antiviral activity 失效
    具有抗病毒活性的咪唑并噻吩衍生物

    公开(公告)号：US4690917A

    公开(公告)日：1987-09-01

    申请号：US800667

    申请日：1985-11-22

    申请人： David J. Knight ,  David I. C. Scopes ,  Richard Storer ,  Stuart Holman

    发明人： David J. Knight ,  David I. C. Scopes ,  Richard Storer ,  Stuart Holman

    IPC分类号： A61K31/50 ,  A61P31/12 ,  C07D487/04 ,  C07D519/00 ,  A61K31/70 ,  C07H3/02

    CPC分类号： C07D487/04 ,  Y02P20/55

    摘要： Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.3 and R.sub.4 each independently represents a hydrogen atom or a protecting group;R.sub.2 represents a halogen atom or a group of formula --NR.sub.a R.sub.b (where R.sub.a and R.sub.b, which may be the same or different, each represents a hydrogen atom or an alkyl group; or R.sub.a and R.sub.b may be linked to form, together with the nitrogen atom to which they are attached, a heterocyclic ring which optionally contains a further heteroatom);and their physiological equivalents as well as salts thereof with acids, exhibit antiviral activity against RNA viruses such as Influenza and/or are intermeidates for the preparation of antivirally active compounds.

    摘要翻译： 下式的化合物：其中R 1，R 3和R 4各自独立地表示氢原子或保护基; R 2表示卤素原子或式-NR a R b的基团（其中R a和R b可以相同或不同，各自表示氢原子或烷基;或者R a和R b可以与 它们所连接的氮原子，任选地含有另外的杂原子的杂环）; 和它们的生理等同物以及其与酸的盐，表现出对RNA病毒如流感的抗病毒活性和/或是用于制备抗病毒活性化合物的中间体。

    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
    6.
    发明授权
    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections 有权
    2'和3'-核苷前药用于治疗黄病毒科感染

    公开(公告)号：US07625875B2

    公开(公告)日：2009-12-01

    申请号：US11005444

    申请日：2004-12-06

    申请人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    发明人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07K9/003 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07H19/06 ,  C07H19/067 ,  A61K2300/00

    摘要： 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

    摘要翻译： 描述了1'，2'，3'或4'-支链β-D或β-L核苷的2'和3'-前药，或其药学上可接受的盐和衍生物，其可用于预防和治疗黄病毒科 感染等相关条件。 这些修饰的核苷对黄病毒和瘟病毒提供了优异的结果，包括丙型肝炎病毒和通常通过RNA依赖性RNA逆转录酶复制的病毒。 提供化合物，组合物，方法和用途用于治疗包括HCV感染在内的黄病毒科感染，包括施用有效量的本发明前药或其药学上可接受的盐或衍生物。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。