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公开(公告)号：US6080198A
公开(公告)日：2000-06-27
申请号：US964414
申请日：1997-11-04
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US5607478A
公开(公告)日：1997-03-04
申请号：US616047
申请日：1996-03-14
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US5874032A
公开(公告)日：1999-02-23
申请号：US545799
申请日：1996-04-15
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/864 , B29C47/866 , B29C47/0016 , B29K2027/18 , B29L2031/753
摘要： An improved method is provided for extruding ePTFE tube (12) for use in medical applications. A tube (12) of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components (22, 26). The die component (16) is maintained at a constant temperature during processing. The resulting green tube (12) has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube (12) is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube (12) structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube (12). This particular structure yields a tube (12) which exhibits a high degree of radial tear strength useful in medical applications.
摘要翻译： PCT No.PCT / US95 / 03018 Sec。 371日期：1996年4月15日 102（e）日期1996年4月15日PCT 1995年3月9日PCT公布。 公开号WO95 / 24304 日期1995年9月14日提供用于挤出用于医疗应用的ePTFE管（12）的改进方法。 PTFE的管（12）优选地在挤出过程中使用反向旋转的模具部件（22,26）挤出。 在加工期间，模具部件（16）保持恒定的温度。 所得到的绿色管（12）在垂直于挤出方向的方向上具有增强的纤维形成。 然后将PTFE绿色管（12）进行二次操作，例如拉伸和膨胀以产生医疗产品。 ePTFE管（12）结构由通过细长原纤维互连的节点限定。 节点和原纤维相对于管（12）的纵向轴线基本上随机倾斜。 这种特殊的结构产生一个管（12），其在医疗应用中表现出高度的径向撕裂强度。
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公开(公告)号：US06530765B1
公开(公告)日：2003-03-11
申请号：US09595548
申请日：2000-06-16
IPC分类号： B29C4724
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/866 , B29K2027/18 , B29L2031/753 , C08L27/18
摘要： An improved method and apparatus is provided for extruding ePTFE tube for use in medical applications. A tube of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components. The die component is maintained at a constant temperature during processing. The resulting green tube has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube. This particular structure yields a tube which exhibits a high degree of radial tear strength useful in medical applications.
摘要翻译： 提供了用于挤出用于医疗应用的ePTFE管的改进的方法和装置。 使用反向旋转的模具部件挤压PTFE管，优选在挤出工艺中。 在加工过程中，模具部件保持恒定的温度。 所得到的绿色管在垂直于挤出方向的方向上增强了纤维形态。 然后对PTFE绿色管进行拉伸和膨胀等二次操作以产生医疗产品。 ePTFE管结构由通过细长纤维互连的节点限定。 节点和原纤维相对于管的纵向轴线基本上随机倾斜。 这种特殊结构产生了一种在医疗应用中显示高度径向撕裂强度的管。
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公开(公告)号：US6001125A
公开(公告)日：1999-12-14
申请号：US40880
申请日：1998-03-18
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube. The stent provides patency to the endoprosthesis.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。 支架对内假体提供通畅。
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公开(公告)号：US6036724A
公开(公告)日：2000-03-14
申请号：US8265
申请日：1998-01-16
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。
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公开(公告)号：US5800512A
公开(公告)日：1998-09-01
申请号：US588052
申请日：1996-01-22
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。
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8.发明授权ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin 失效ePTFE小口径血管移植物通过包含共价键合的肝素的表面涂层具有显着的通畅性增强公开(公告)号：US06306165B1
公开(公告)日：2001-10-23
申请号：US08713800
申请日：1996-09-13
IPC分类号： A61F206
CPC分类号： A61L27/34 , A61L27/507 , A61L33/0029 , A61L33/0047 , A61L33/0094
摘要： Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.
摘要翻译： 公开了具有增强的通畅的可植入医疗装置。 公开了扩张聚四氟乙烯小口径血管移植物，其涂覆有聚合物结合的生物活性剂，其显示增强的通畅。 聚合物结合的生物活性剂可以包括抗血栓形成剂，抗生素，抗菌剂和抗病毒剂。 还提供了制备方法。
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公开(公告)号：US5716660A
公开(公告)日：1998-02-10
申请号：US455714
申请日：1995-05-31
摘要： An implantable prosthesis comprising an expanded polytetraethylene member having pores present in its wall structure wherein said pores contain a solid insoluble biocompatible, biodegradable material of natural origin. A process of preparing said prostheses is also disclosed.
摘要翻译： 一种可植入假体，其包含在其壁结构中存在的孔的膨胀聚四亚乙基构件，其中所述孔含有天然来源的固体不溶性生物相容性可生物降解的材料。 还公开了制备所述假体的方法。
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公开(公告)号：US5505887A
公开(公告)日：1996-04-09
申请号：US209543
申请日：1994-03-10
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/864 , B29C47/866 , B29C47/0016 , B29K2027/18 , B29L2031/753
摘要： An improved extrusion method is employed in a process which is used to form tubing for medical applications. The method includes providing an extrusion apparatus having a die which includes a die cavity and a mandrel within the die cavity. The die is rotated in a first rotational direction while the mandrel is rotated in a second rotational direction opposite the first direction. While the die and the mandrel are rotating, a PTFE paste is passed through the annular passage defined between the die and the mandrel. The die cavity is cooled to maintain the PTFE paste passing therethrough at a substantially non-elevated temperature.
摘要翻译： 在用于形成用于医疗应用的管道的方法中采用改进的挤出方法。 该方法包括提供具有模具的挤出设备，该模具在模腔内包括模腔和心轴。 模具沿着第一旋转方向旋转，同时心轴沿与第一方向相反的第二旋转方向旋转。 当模具和心轴旋转时，PTFE浆料通过限定在模具和心轴之间的环形通道。 冷却模腔以保持PTFE浆料在基本上不升高的温度下通过。
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