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公开(公告)号：US20130210733A1
公开(公告)日：2013-08-15
申请号：US13704216
申请日：2011-06-16
IPC分类号： A61K31/517 , A61K38/05 , A61K45/06 , A61K31/353 , A61K31/437
CPC分类号： A61K31/517 , A61K31/00 , A61K31/137 , A61K31/353 , A61K31/437 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods of treating lung disease in a subject by administering to the subject a therapeutically effective amount of a mitotic kinesin inhibitor, optionally in combination with another therapy.
摘要翻译： 本文提供了通过向受试者施用治疗有效量的有丝分裂驱动蛋白抑制剂，任选地与另一种治疗组合来治疗受试者的肺部疾病的方法。
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2.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US06743599B1
公开(公告)日：2004-06-01
申请号：US10106665
申请日：2002-03-25
IPC分类号： C12Q142
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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3.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US06410254B1
公开(公告)日：2002-06-25
申请号：US09314464
申请日：1999-05-18
IPC分类号： C12Q142
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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4.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US07378254B2
公开(公告)日：2008-05-27
申请号：US11655733
申请日：2007-01-18
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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公开(公告)号：US07202051B1
公开(公告)日：2007-04-10
申请号：US11270193
申请日：2005-11-08
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
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公开(公告)号：US20090029344A1
公开(公告)日：2009-01-29
申请号：US12150596
申请日：2008-04-28
IPC分类号： C12Q1/00
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
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7.发明申请COMPOSITIONS AND ASSAYS UTILIZING ADP OR PHOSPHATE FOR DETECTING PROTEIN MODULATORS 审中-公开用于检测蛋白质调节剂的ADP或磷酸酯的组成和测定公开(公告)号：US20090117534A1
公开(公告)日：2009-05-07
申请号：US12253877
申请日：2008-10-17
IPC分类号： C12Q1/25
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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8.发明申请Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US20070254310A1
公开(公告)日：2007-11-01
申请号：US11655733
申请日：2007-01-18
申请人： Jeffrey Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： G01N33/573
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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公开(公告)号：US08587670B2
公开(公告)日：2013-11-19
申请号：US12096235
申请日：2006-11-16
申请人： Kenneth Wood , Stephen Hodges , Lyndsay Williams , James Srinivasan , Carsten Rother , Antonio Criminisi , John Chiloyan
发明人： Kenneth Wood , Stephen Hodges , Lyndsay Williams , James Srinivasan , Carsten Rother , Antonio Criminisi , John Chiloyan
IPC分类号： H04N5/225
CPC分类号： H04N5/232 , G06F19/00 , H04N1/00323 , H04N1/2112 , H04N5/23245 , H04N2201/212
摘要： An image capture device is described which is operable in any one of a number of capture modes. The device comprises a camera, a memory and a processor. The memory stores a plurality of sets of capture triggers, with each set of capture triggers being associated with one of the plurality of capture modes. The processor selects one of the plurality of capture modes, such that the device is operable in the selected capture mode. In the selected capture mode, an image is captured automatically when a capture trigger within the associated set of capture triggers is satisfied.
摘要翻译： 描述了可以以多种捕获模式中的任何一种操作的图像捕获装置。 该装置包括相机，存储器和处理器。 存储器存储多组捕获触发，其中每组捕获触发与多个捕获模式之一相关联。 所述处理器选择所述多个捕获模式之一，使得所述设备在所选择的捕获模式中可操作。 在选择的拍摄模式下，当相关联的捕捉触发组中的捕获触发被满足时，会自动捕获图像。
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公开(公告)号：US20070230801A1
公开(公告)日：2007-10-04
申请号：US11760124
申请日：2007-06-08
申请人： David Sinclair , Kenneth Wood
发明人： David Sinclair , Kenneth Wood
IPC分类号： G06F17/30
CPC分类号： G06F17/30256 , G06F17/3025 , G06F17/30262 , G06F17/30265 , G06K9/4652 , G06K9/4685
摘要： A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analysed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet, is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analysed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8). Library images having matching regions are retrieved from the library (1).
摘要翻译： 提供了用于对图书馆（1）中的图像进行分类以用于随后的选择性检索的技术。 每个库图像被分段（2）成多个相干区域。 针对多个视觉特性来分析每个区域，每个视觉属性根据视觉属性的值归入一个数字。 然后将属性编号与可用属性范围的带进行比较（4），并将计算机可读字符（例如字母表的字母）归因于每个属性值。 然后以预定顺序布置（5）字符以形成区域字符串。 然后对每个区域的字符串进行索引（7），以按区域字符串形成图像的索引（8）。 对于图像检索，以相同的方式分析目标图像（10）以形成区域字符串，然后提供给文本检索系统（12），用于检测与索引（8）中的条目的匹配。 从库（1）检索具有匹配区域的库图像。
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