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9 条记录 (耗时 0.061 秒)

    Methods for treating an ischemic disorder and improving stroke outcome
    2.
    发明授权
    Methods for treating an ischemic disorder and improving stroke outcome 失效
    治疗缺血性疾病和改善中风结局的方法

    公开(公告)号：US06315995B1

    公开(公告)日：2001-11-13

    申请号：US09053871

    申请日：1998-04-01

    申请人： David J. Pinsky ,  David Stern ,  Ann Marie Schmidt ,  Eric Rose ,  Robert A. Solomon

    发明人： David J. Pinsky ,  David Stern ,  Ann Marie Schmidt ,  Eric Rose ,  Robert A. Solomon

    IPC分类号： A61K3816

    CPC分类号： C12N9/644 ,  A61K38/4846 ,  C07K14/70564 ,  C07K16/2854 ,  C12Y304/21022

    摘要： The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable Factor IXa compound in a sufficient amount over a sufficient time period so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IXa in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.

    摘要翻译： 本发明提供一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的药学上可接受的因子IXa化合物，以治疗受试者的缺血性疾病。 本发明还提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IXa以抑制凝血，以便治疗缺血性疾病 学科。

    Solution for prolonged organ preservation
    3.
    发明授权
    Solution for prolonged organ preservation 失效
    长期器官保存的解决方案

    公开(公告)号：US5370989A

    公开(公告)日：1994-12-06

    申请号：US206197

    申请日：1994-03-03

    申请人： David M. Stern ,  Mehmet C. Oz ,  Roman Nowygrod ,  Shin Koga ,  David J. Pinsky

    发明人： David M. Stern ,  Mehmet C. Oz ,  Roman Nowygrod ,  Shin Koga ,  David J. Pinsky

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： The present invention provides an aqueous solution for organ preservation or maintenance, including: a vasodilator in an amount sufficient to maintain vascular homeostasis; D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability; potassium ions in a concentration greater than about 110 mM; and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about the physiologic pH value. The invention also provides a method of preserving or maintaining an organ, including contacting the organ with the solution.

    摘要翻译： 本发明提供了一种用于器官保存或维持的水溶液，包括：足以维持血管内环境稳定的血管扩张剂; D-葡萄糖的量足以支持细胞内功能和维持细胞生物能量; 足以支持细胞内功能和维持细胞生物能量的镁离子; 分子量大于20,000道尔顿的大分子，其量足以维持内皮完整性和细胞活力; 浓度大于约110mM的钾离子; 以及足以在器官保存期间在约生理pH值下保持器官保存或维持溶液的平均pH的缓冲剂。 本发明还提供了保存或维持器官的方法，包括使器官与溶液接触。

    CD39/ECTO-adpase as a treatment for thrombotic and ischemic disorders
    4.
    发明授权
    CD39/ECTO-adpase as a treatment for thrombotic and ischemic disorders 失效
    CD39 / ECTO-adpase作为血栓形成和缺血性疾病的治疗

    公开(公告)号：US06867177B2

    公开(公告)日：2005-03-15

    申请号：US09374586

    申请日：1999-08-13

    申请人： David J. Pinsky

    发明人： David J. Pinsky

    IPC分类号： A61K38/00 ,  C07K14/705 ,  A01N37/18 ,  C07K1/00

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： The present invention provides a method of treating or preventing thrombotic or ischemic disorders in a subject which comprises administering an agent to the subject, wherein the agent inhibits ADP-mediated platelet aggregation by increasing ADP catabolism, and a method for determining whether a compound inhibits platelet aggregation by increasing ADP catabolism so as to treat or prevent thrombotic or ischemic disorders in a subject, comprising: (a) inducing thrombotic or ischemic disorders in an animal, which animal is an animal model for thrombotic or ischemic disorders; (b) measuring the stroke outcome in the animal, (c) measuring platelet deposition and/or fibrin deposition in ischemic tissue, and (d) comparing the stroke outcome in step (b) and the platelet deposition and/or fibrin deposition with that of the animal model in the absence of the compound so as to identify a compound capable of treating or preventing thrombotic or ischemic disorders in a subject.

    摘要翻译： 本发明提供了治疗或预防受试者血栓形成或缺血性疾病的方法，其包括向受试者施用药剂，其中所述药物通过增加ADP分解代谢来抑制ADP介导的血小板聚集，以及用于确定化合物是否抑制血小板的方法 通过增加ADP分解代谢来治疗或预防受试者的血栓形成或缺血性疾病，其包括：（a）在动物中诱导血栓形成或缺血性疾病，所述动物是血栓形成或缺血性障碍的动物模型; （b）测量动物的中风结局，（c）测量缺血组织中的血小板沉积和/或纤维蛋白沉积，和（d）将步骤（b）中的中风结果与血小板沉积和/或纤维蛋白沉积与 的化合物，以鉴定能够治疗或预防受试者血栓形成或缺血性疾病的化合物。

    Solution for prolonged organ preservation
    6.
    发明授权
    Solution for prolonged organ preservation 失效
    长期器官保存的解决方案

    公开(公告)号：US5552267A

    公开(公告)日：1996-09-03

    申请号：US350319

    申请日：1994-12-05

    申请人： David M. Stern ,  Mehmet C. Oz ,  Roman Nowygrod ,  Shin Koga ,  David J. Pinsky

    发明人： David M. Stern ,  Mehmet C. Oz ,  Roman Nowygrod ,  Shin Koga ,  David J. Pinsky

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： An aqueous solution for organ preservation or maintenance, which contains: a vasodilator in an amount sufficient to maintain vascular homeostasis; D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability; potassium ions in a concentration greater than about 110 mM; and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about physiologic pH or above.

    摘要翻译： 用于器官保存或维持的水溶液，其包含：足以维持血管内环境稳定的血管扩张剂; D-葡萄糖的量足以支持细胞内功能和维持细胞生物能量; 足以支持细胞内功能和维持细胞生物能量的镁离子; 分子量大于20,000道尔顿的大分子，其量足以维持内皮完整性和细胞活力; 浓度大于约110mM的钾离子; 以及足以在器官保存期间在约生理pH或以上保持器官保存或维持溶液的平均pH的量的缓冲液。

    Methods for treating ischemic disorders using carbon monoxide
    7.
    发明授权
    Methods for treating ischemic disorders using carbon monoxide 有权
    使用一氧化碳治疗缺血性疾病的方法

    公开(公告)号：US08128963B2

    公开(公告)日：2012-03-06

    申请号：US10679135

    申请日：2003-10-03

    申请人： David J. Pinsky ,  David M. Stern ,  Charles J. Prestigiacome

    发明人： David J. Pinsky ,  David M. Stern ,  Charles J. Prestigiacome

    IPC分类号： A61K33/00 ,  A61P9/10

    CPC分类号： C12N9/644 ,  A61K38/4846 ,  C07K14/70564 ,  C07K16/2854 ,  C12Y304/21022

    摘要： The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of a selectin antagonist in a sufficient amount over a sufficient time period to prevent white blood cell accumulation so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject carbon monoxide gas in a sufficient amount over a sufficient period of time thereby treating the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IX in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.

    摘要翻译： 本发明提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够量的时间向所述受试者施用药学上可接受的形式的选择素拮抗剂，以防止白细胞积聚，从而治疗缺血性 主题无序。 本发明进一步提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的一氧化碳气体，从而治疗受试者的缺血性疾病。 本发明进一步提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IX以抑制凝血，以便治疗缺血性障碍 学科。

    NUCLEOTIDE PHOSPHATE DISSIPATION AS A TREATMENT FOR VASCULAR DISORDERS
    8.
    发明申请
    NUCLEOTIDE PHOSPHATE DISSIPATION AS A TREATMENT FOR VASCULAR DISORDERS 审中-公开
    磷酸氢钙作为血管疾病的治疗药物

    公开(公告)号：US20090130092A1

    公开(公告)日：2009-05-21

    申请号：US12261870

    申请日：2008-10-30

    申请人： David J. Pinsky ,  Danica Petrovic-Djergovic

    发明人： David J. Pinsky ,  Danica Petrovic-Djergovic

    IPC分类号： A61K39/395 ,  A61K38/43

    CPC分类号： A61K38/465 ,  C12Y301/03005

    摘要： The present invention provides a method of treating or preventing immunoinflammatory, vascular, thrombotic or ischemic disorders in a subject, the method comprises administering to the subject an agent which dissipates nucleotide phosphates or generates a product which stimulates adenosine receptors. The present invention also provides a method of treating or preventing immunoinflammatory, thrombotic or ischemic disorders in a subject by inhibiting leukocyte infiltration into a site which comprises administering to the subject an effective amount a described agent. Agents described for use in the methods of the invention include CD73, a fragment a mutant, or a modified form thereof.

    摘要翻译： 本发明提供了治疗或预防受试者的免疫炎症，血管，血栓形成或缺血性疾病的方法，所述方法包括向受试者施用耗散磷酸核苷酸或产生刺激腺苷受体的产物的药剂。 本发明还提供了通过抑制白细胞浸润到一个部位来治疗或预防受试者的免疫炎性，血栓形成或缺血性疾病的方法，其包括向受试者施用有效量的所述试剂。 描述用于本发明方法的试剂包括CD73，突变体片段或其修饰形式。