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1.发明申请POLYDIAZENIUMDIOLATED CYCLIC POLYAMINES WITH POLYPHASIC NITRIC OXIDE RELEASE AND RELATED COMPOUNDS, COMPOSITIONS COMPRISING SAME AND METHODS OF USING SAME 失效具有多环氮氧化物释放的聚二
亚乙基环状聚酰胺及其相关化合物，包含它们的组合物和使用它们的方法公开(公告)号：US20090068248A1
公开(公告)日：2009-03-12
申请号：US12268855
申请日：2008-11-11
IPC分类号： A61F2/04 , C07C245/00 , A61F2/06 , A61F2/82 , A61K31/655
CPC分类号： C07D255/00 , C07D257/02 , C07D259/00
摘要： The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
摘要翻译： 本发明提供式（I）化合物：其中R 1，R 2，R 3，R 4，R 5和R 6中的至少两个是N 2 O 2 M和相关化合物，使用这些化合物和组合物的底物，组合物和方法 其中一氧化氮的多相释放将是有益的生物学障碍。
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2.发明授权Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same 失效具有多相一氧化氮释放和相关化合物的聚二氮茚二环状多胺，包含其的组合物及其使用方法公开(公告)号：US07468435B2
公开(公告)日：2008-12-23
申请号：US10982576
申请日：2004-11-05
IPC分类号： C07D245/00
CPC分类号： C07D255/00 , C07D257/02 , C07D259/00
摘要： The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
摘要翻译： 本发明提供式（I）化合物：其中R 1，R 2，R 3，R 4，R 5和R 6中的至少两个是N 2 O 2 M和相关化合物的底物，组合物和使用这些化合物和组合物来治疗生物 其中一氧化氮的多相释放将是有益的障碍。
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3.发明授权Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same 失效具有多相一氧化氮释放和相关化合物的聚二氮茚二环状多胺，包含其的组合物及其使用方法公开(公告)号：US07928096B2
公开(公告)日：2011-04-19
申请号：US12268855
申请日：2008-11-11
IPC分类号： A61K31/33 , C07D255/02 , C07D257/02 , C07D259/00
CPC分类号： C07D255/00 , C07D257/02 , C07D259/00
摘要： The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
摘要翻译： 本发明提供式（I）化合物：其中R 1，R 2，R 3，R 4，R 5和R 6中的至少两个是N 2 O 2 M和相关化合物，使用这些化合物和组合物的底物，组合物和方法 其中一氧化氮的多相释放将是有益的生物学障碍。
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4.发明授权Methods for separation and detection of ketosteroids and other carbonyl-containing compounds 有权分离和检测酮类和其他含羰基化合物的方法公开(公告)号：US07807472B2
公开(公告)日：2010-10-05
申请号：US10511409
申请日：2003-04-15
CPC分类号： G01N33/743 , G01N30/02 , G01N30/7233 , G01N30/7266 , Y10S436/817 , Y10T436/24 , B01D15/325
摘要： Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.
摘要翻译： 公开了通过质谱（MS）检测和/或含羰基化合物如类固醇的色谱分离性的方法。 羰基化合物与磺酰肼化合物的反应提供了在电喷雾电离过程期间具有增强的电离效率的磺酰腙。 在特别公开的实施方案中，儿茶酚雌激素与对甲苯磺酰肼的衍生增强了通过大气压电离-MS（API-MS）的检测，例如电子喷雾离子化-MS（ESI-MS）和通过液相色谱法分离（例如HPLC ）在反相条件下。 在其它实施方案中，磺酰腙在碱性条件下进一步与磺酰卤反应以衍生化合物中的羟基。 磺酰肼衍生物的先前形成在与磺酰卤的随后碱性反应期间保护化合物的羰基键。
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