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公开(公告)号：US07381747B2
公开(公告)日：2008-06-03
申请号：US11470730
申请日：2006-09-07
IPC分类号： A01N37/12
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; andR2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US20090203782A1
公开(公告)日：2009-08-13
申请号：US12426501
申请日：2009-04-20
IPC分类号： A61K31/195 , A61P37/06 , A61P29/00
CPC分类号： A61K45/06 , A61K31/195
摘要： This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及通过给予式1化合物或其药学上可接受的盐来治疗某些疾病的方法，其中：R1是氢，1至6个碳原子的直链或支链烷基或苯基; 并且R 2是4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个碳原子的烷氧基， - 烷基环烷基， - 烷基烷氧基 ， - 烷基OH， - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US07164034B2
公开(公告)日：2007-01-16
申请号：US10734917
申请日：2003-12-12
IPC分类号： C07C10/00
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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4.发明申请Gabapentin for the Treatment of Overactive Bladder, Stress Incontinence and BPH 审中-公开加巴喷丁用于治疗膀胱过度活动症，应力失禁和BPH公开(公告)号：US20110039899A1
公开(公告)日：2011-02-17
申请号：US12200191
申请日：2008-08-28
申请人： Charles Price Taylor, JR. , Andrew John Thorpe , Simon Lemprier Westbrook , David Juergen Wustrow
发明人： Charles Price Taylor, JR. , Andrew John Thorpe , Simon Lemprier Westbrook , David Juergen Wustrow
IPC分类号： A61K31/4245 , A61K31/195 , A61K31/41 , A61K31/40 , A61P13/00
CPC分类号： A61K31/662 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06
摘要： Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of LUTS, other than urinary incontinence, associated with OAB and/or BPH.
摘要翻译： α-2-δ配体或其药学上可接受的衍生物在制备用于治疗与OAB和/或BPH相关的尿失禁的LUTS的药物中的用途。
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公开(公告)号：US07432299B2
公开(公告)日：2008-10-07
申请号：US10726878
申请日：2003-12-02
申请人： Charles Price Taylor, Jr. , Andrew John Thorpe , Pieter Hadewijn Van Der Graaf , Christopher Peter Wayman , David Juergen Wustrow
发明人： Charles Price Taylor, Jr. , Andrew John Thorpe , Pieter Hadewijn Van Der Graaf , Christopher Peter Wayman , David Juergen Wustrow
IPC分类号： A61K31/195
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06
摘要： Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of premature ejaculation.
摘要翻译： α-2-δ配体或其药学上可接受的衍生物在制备用于治疗早泄的药物中的用途。
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公开(公告)号：US20080207755A1
公开(公告)日：2008-08-28
申请号：US12102268
申请日：2008-04-14
CPC分类号： A61K31/198
摘要： This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein:R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; andR2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及通过给予式1化合物或其药学上可接受的盐来治疗某些疾病的方法，其中：R 1是氢，1至6个碳原子的直链或支链烷基 或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US07122678B2
公开(公告)日：2006-10-17
申请号：US11078961
申请日：2005-03-11
申请人： Justin Stephen Bryans , David Christopher Horwell , Andrew John Thorpe , David Juergen Wustrow , Po-Wai Yuen
发明人： Justin Stephen Bryans , David Christopher Horwell , Andrew John Thorpe , David Juergen Wustrow , Po-Wai Yuen
IPC分类号： C07D209/54 , C07C69/74 , C07C61/06
CPC分类号： C07D221/20 , C07C49/417 , C07C69/608 , C07C69/612 , C07C205/51 , C07C205/53 , C07C229/28 , C07C229/34 , C07C2601/04 , C07C2601/08 , C07C2602/50 , C07D209/96 , C07D307/94 , C07D311/96
摘要： The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
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公开(公告)号：US06921835B2
公开(公告)日：2005-07-26
申请号：US10448834
申请日：2003-05-30
申请人： Justin Stephen Bryans , David Christopher Horwell , Andrew John Thorpe , David Juergen Wustrow , Po-Wai Yuen
发明人： Justin Stephen Bryans , David Christopher Horwell , Andrew John Thorpe , David Juergen Wustrow , Po-Wai Yuen
IPC分类号： A61P1/04 , A61K20060101 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/215 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , C07C20060101 , C07C61/04 , C07C61/06 , C07C69/608 , C07C69/612 , C07C205/51 , C07C205/53 , C07C229/00 , C07C229/28 , C07C229/32 , C07C229/34 , C07D209/96 , C07D221/20 , C07D307/94 , C07D311/96
CPC分类号： C07D221/20 , C07C49/417 , C07C69/608 , C07C69/612 , C07C205/51 , C07C205/53 , C07C229/28 , C07C229/34 , C07C2601/04 , C07C2601/08 , C07C2602/50 , C07D209/96 , C07D307/94 , C07D311/96
摘要： The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
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公开(公告)号：US06436974B1
公开(公告)日：2002-08-20
申请号：US09980187
申请日：2001-11-30
IPC分类号： A61K314245
CPC分类号： C07D403/04 , C07D413/04
摘要： The instant invention is a novel series of amino heterocycles useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, and sleep disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed.
摘要翻译： 本发明是用于治疗癫痫，微弱发作，运动功能减退，颅内障碍，神经变性障碍，抑郁，焦虑，恐慌，疼痛，神经病理学障碍和睡眠障碍的新型氨基杂环。 还公开了用于制备的方法和可用于制备的中间体。
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公开(公告)号：US07250433B2
公开(公告)日：2007-07-31
申请号：US10795760
申请日：2004-03-08
申请人： Nancy Sue Barta , Norman Lloyd Colbry , Raymond Hudack, Jr. , Kristin Knapp Lin , Jacob Bradley Schwarz , Andrew John Thorpe , David Juergen Wustrow , Zhijian Zhu
发明人： Nancy Sue Barta , Norman Lloyd Colbry , Raymond Hudack, Jr. , Kristin Knapp Lin , Jacob Bradley Schwarz , Andrew John Thorpe , David Juergen Wustrow , Zhijian Zhu
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D257/04 , C07D271/07
摘要： This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl β-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (α2δ ligands). Such compounds have affinity for the α2δ subunit of a calcium channel.
摘要翻译： 本发明涉及下式的新型四唑和恶二唑类β-氨基酸衍生物，其中G是其中R 1至R 4定义如说明书中所定义，含有它们的药物组合物 及其用于治疗各种中枢神经系统等疾病的用途。 本发明的环丙基β-氨基酸衍生物表现出作为α2delta配体（α2delta配体）的活性。 这些化合物对钙离子通道的α2delta亚基具有亲和力。
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