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公开(公告)号：US07381747B2
公开(公告)日：2008-06-03
申请号：US11470730
申请日：2006-09-07
IPC分类号： A01N37/12
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; andR2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US20090203782A1
公开(公告)日：2009-08-13
申请号：US12426501
申请日：2009-04-20
IPC分类号： A61K31/195 , A61P37/06 , A61P29/00
CPC分类号： A61K45/06 , A61K31/195
摘要： This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及通过给予式1化合物或其药学上可接受的盐来治疗某些疾病的方法，其中：R1是氢，1至6个碳原子的直链或支链烷基或苯基; 并且R 2是4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个碳原子的烷氧基， - 烷基环烷基， - 烷基烷氧基 ， - 烷基OH， - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US07164034B2
公开(公告)日：2007-01-16
申请号：US10734917
申请日：2003-12-12
IPC分类号： C07C10/00
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US20080207755A1
公开(公告)日：2008-08-28
申请号：US12102268
申请日：2008-04-14
CPC分类号： A61K31/198
摘要： This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein:R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; andR2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及通过给予式1化合物或其药学上可接受的盐来治疗某些疾病的方法，其中：R 1是氢，1至6个碳原子的直链或支链烷基 或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US07138542B2
公开(公告)日：2006-11-21
申请号：US11314126
申请日：2005-12-21
IPC分类号： C07C61/06 , C07C61/08 , C07C53/126 , C07C53/134 , C07C53/136 , A61K31/131
CPC分类号： A61K31/131 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/18 , A61K31/41 , A61K31/4245 , A61K31/443 , A61K31/662
摘要： The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
摘要翻译： 本发明涉及一种治疗耳鸣的方法，该方法是通过给予α2δ配体，例如其中R 1是氢或直链或支链低级烷基的式及其药学上可接受的盐的化合物，和 n为4〜6的整数。
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公开(公告)号：US07026505B2
公开(公告)日：2006-04-11
申请号：US10353367
申请日：2003-01-29
IPC分类号： C07C229/08 , C07C229/06 , C07C229/04 , C07C229/02 , C07C229/00
CPC分类号： A61K31/131 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/18 , A61K31/41 , A61K31/4245 , A61K31/443 , A61K31/662
摘要： The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
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公开(公告)号：US20120329781A1
公开(公告)日：2012-12-27
申请号：US13597462
申请日：2012-08-29
IPC分类号： A61K31/195 , A61K31/4245 , A61K31/41 , A61K31/20 , A61K31/4525 , A61K31/343 , A61K31/451 , A61K31/496 , A61K31/445 , A61K31/38 , A61K31/4465 , A61K31/5375 , A61K31/55 , A61K31/415 , A61K31/381 , A61P29/00 , A61P25/00 , A61K31/197
CPC分类号： A61K31/5375 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/196 , A61K31/197 , A61K31/381 , A61K45/06 , A61K2300/00
摘要： The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.
摘要翻译： 本发明涉及α-2-δ配体和双重5-羟色胺 - 去甲肾上腺素再吸收抑制剂（DSNRI）或选择性5-羟色胺再吸收抑制剂（SSRI）和其中一种或两种的组合，特别是协同组合 选择性去甲肾上腺素再摄取抑制剂（SNRI）及其药学上可接受的盐，其药物组合物及其在治疗疼痛，特别是神经性疼痛中的用途。
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公开(公告)号：US07517002B2
公开(公告)日：2009-04-14
申请号：US11422611
申请日：2006-06-07
CPC分类号： B60N3/12
摘要： A pocketed panel assembly for a vehicle door is disclosed herein. The pocketed panel assembly includes a trim panel, a partial pocket structure, and a living hinge. The trim panel has a pivotal edge, and the partial pocket structure also has a pivotal edge. The living hinge integrally joins the pivotal edge of the trim panel to the pivotal edge of the partial pocket structure. In such a configuration, the partial pocket structure can be rotated about the living hinge and substantially abutted against the trim panel so as to form an open pocket on the trim panel.
摘要翻译： 本文公开了一种用于车门的袋式面板组件。 袋装面板组件包括装饰面板，部分口袋结构和活动铰链。 装饰板具有枢转边缘，并且部分凹穴结构还具有枢转边缘。 活动铰链将装饰板的枢转边缘一体地连接到部分凹穴结构的枢转边缘。 在这种构造中，部分袋结构可以围绕活动铰链旋转并且基本上抵靠装饰板，以便在装饰板上形成开口袋。
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9.发明授权Vehicle interior trim panel assembly having an integrated soft-touch arm rest and method of manufacturing same 失效具有集成的软触摸扶手的车辆内饰板组件及其制造方法公开(公告)号：US07005092B2
公开(公告)日：2006-02-28
申请号：US10439524
申请日：2003-05-16
申请人： David James Dooley , Mark Fero
发明人： David James Dooley , Mark Fero
IPC分类号： B29C44/06
CPC分类号： B32B5/18 , B29C44/18 , Y10T428/24331
摘要： The present invention relates to a method of manufacturing an interior trim panel assembly having an integrated soft-touch area for improved aesthetic trim component quality. The method of manufacturing a trim panel assembly for the interior of a vehicle having an integrated soft-touch area of the present invention includes placing a molded trim panel including a coverstock having an exposed outer surface and a foam backing disposed opposite the outer surface and a rigid substrate having at least one aperture bonded to the coverstock into a mold cavity. The method of manufacture further includes separating the bonded coverstock and rigid polymer substrate in a localized area to define an internal chamber accessible by the aperture. The method of manufacture also includes injecting soft foam into the internal chamber through the aperture so as to be juxtaposed between the coverstock and the rigid polymer substrate in at least one predetermined location to define an integrated soft-touch area.
摘要翻译： 本发明涉及一种制造具有集成的柔软触感区域的内装饰板组件的方法，以提高美学装饰件的质量。 制造具有本发明的集成软触摸区域的车辆内部的装饰板组件的方法包括：将包括具有暴露的外表面和与外表面相对设置的泡沫背衬的封面的模制装饰板放置在一起， 刚性基底具有至少一个孔，其结合到覆盖物到模腔中。 制造方法还包括在局部区域中分离粘合的覆盖物和刚性聚合物基质以限定由孔可接近的内部室。 制造方法还包括通过孔将软泡沫喷射到内室中，以便在至少一个预定位置上并置在覆盖物和刚性聚合物基底之间，以限定整合的软触摸区域。
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公开(公告)号：US20070284902A1
公开(公告)日：2007-12-13
申请号：US11422611
申请日：2006-06-07
IPC分类号： B60N3/12
CPC分类号： B60N3/12
摘要： A pocketed panel assembly for a vehicle door is disclosed herein. The pocketed panel assembly includes a trim panel, a partial pocket structure, and a living hinge. The trim panel has a pivotal edge, and the partial pocket structure also has a pivotal edge. The living hinge integrally joins the pivotal edge of the trim panel to the pivotal edge of the partial pocket structure. In such a configuration, the partial pocket structure can be rotated about the living hinge and substantially abutted against the trim panel so as to form an open pocket on the trim panel.
摘要翻译： 本文公开了一种用于车门的袋式面板组件。 袋装面板组件包括装饰面板，部分口袋结构和活动铰链。 装饰板具有枢转边缘，并且部分凹穴结构还具有枢转边缘。 活动铰链将装饰板的枢转边缘一体地连接到部分凹穴结构的枢转边缘。 在这种构造中，部分袋结构可以围绕活动铰链旋转并且基本上抵靠装饰板，以便在装饰板上形成开口袋。
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