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    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
    1.
    发明授权
    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect 失效
    渗透式输送装置，具有可扩展的孔口用于脉动输送效果

    公开(公告)号：US5318558A

    公开(公告)日：1994-06-07

    申请号：US984387

    申请日：1992-12-01

    申请人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    发明人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.

    摘要翻译： 由胶囊从生理环境渗透输入药物驱动的药物递送胶囊设置有间歇地打开以实现脉动递送效果的输送孔。 其中形成孔的壁由弹性材料构成，弹性材料优选为弹性体，该弹性材料在渗透输液进行时由胶囊内部的压力升高引起的压差下伸展。 孔口足够小，使得当弹性壁松弛时，通过孔口的药物的流速基本上为零，但是当由于壁上的压力差超过阈值而使弹性壁拉伸时，孔口充分扩张到 允许以生理有益的速率释放药物。

    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
    2.
    发明授权
    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect 失效
    渗透式输送装置，具有可扩展的孔口用于脉动输送效果

    公开(公告)号：US5221278A

    公开(公告)日：1993-06-22

    申请号：US849910

    申请日：1992-03-12

    申请人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    发明人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.

    摘要翻译： 由胶囊从生理环境渗透输入药物驱动的药物递送胶囊设置有间歇地打开以实现脉动递送效果的输送孔。 其中形成孔的壁由弹性材料构成，弹性材料优选为弹性体，该弹性材料在渗透输液进行时由胶囊内部的压力升高引起的压差下伸展。 孔口足够小，使得当弹性壁松弛时，通过孔口的药物的流速基本上为零，但是当由于壁上的压力差超过阈值而使弹性壁拉伸时，孔口充分扩张到 允许以生理有益的速率释放药物。

    Ruminal drug delivery device
    5.
    发明授权
    Ruminal drug delivery device 失效

    公开(公告)号：US5904934A

    公开(公告)日：1999-05-18

    申请号：US82196

    申请日：1998-05-21

    申请人： Frederick H. Maruyama ,  Judy A. Magruder

    发明人： Frederick H. Maruyama ,  Judy A. Magruder

    IPC分类号： A61K9/00 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall. The invention is also directed to methods and articles for providing a consistent delivery of drug from a ruminal drug delivery device.

    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
    6.
    发明授权
    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
    用于将流体敏感生长激素递送至牛类动物的渗透系统

    公开(公告)号：US5728088A

    公开(公告)日：1998-03-17

    申请号：US269596

    申请日：1994-07-01

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61D7/00 ,  A61M31/002

    摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal. The exit means may include means for compensating for slight variations in the efflux rate of the beneficial agent and means for maintaining for a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.

    摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 所述壁还可以包括端盖，所述端盖可以包括用于使用于超声波焊接的端盖适配到第一壁部分的装置和用于保持有益剂与出口装置接触的装置。 隔室包括有益剂和可膨胀装置。 递送系统包括用于将有益剂递送到动物的出口装置。 出口装置可以包括用于补偿有益剂的流出速率的轻微变化的装置和用于维持有益剂从装置向外的足够的速度或流出速率的装置，同时最小化流体从外部环境扩散回装置 。

    Implantable delivery dispenser
    7.
    发明授权
    Implantable delivery dispenser 失效
    可搬运分配器

    公开(公告)号：US5112614A

    公开(公告)日：1992-05-12

    申请号：US407489

    申请日：1989-09-14

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Jeremy C. Wright

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Jeremy C. Wright

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.

    摘要翻译： 封闭的可植入分配器包括围绕包含第一组合物的隔室的壁，第一组合物包含有益剂，油，助溶剂和聚合物胶凝剂，第二可膨胀组合物，第一和第二组合物之间的第三边界保持组合物，以及出口 港口。