公开(公告)号：US20050176069A1

公开(公告)日：2005-08-11

申请号：US10650467

申请日：2003-08-28

申请人： David Lowery ,  Timothy Geary ,  Teresa Kubiak ,  Martha Larsen

发明人： David Lowery ,  Timothy Geary ,  Teresa Kubiak ,  Martha Larsen

IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/53 ,  G01N33/567

CPC分类号： C07K14/70571

摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

摘要翻译： 本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。 鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）的广谱无脊椎寄生虫寄生虫。

公开(公告)号：US20130149035A1

公开(公告)日：2013-06-13

申请号：US13413999

申请日：2012-03-07

申请人： Timothy Geary

发明人： Timothy Geary

IPC分类号： E01C11/16 ,  E01C21/00

CPC分类号： E01C5/12 ,  E01C11/005 ,  E01C23/06

摘要： A road patch for repair of potholes is disclosed. A pothole is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, a road patch is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The road patch forms a water proof seal over the surface area of the patch preventing water from seeping into the repaired pothole. The patch also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill.

摘要翻译： 公开了修补坑洼的道路补丁。 用沥青填充物预先修复坑洞，并按照当前的标准做法进行压实。 此后，将道路贴片放置在沥青填充物的压实顶表面上，重叠在相邻路面上并压缩。 道路贴片在贴剂的表面积上形成防水密封，防止水渗入修复的坑洞中。 该贴片还抵抗裂纹扩展，并最大限度地减少沥青切屑的可能性和沥青填料的破裂。

公开(公告)号：US08534954B2

公开(公告)日：2013-09-17

申请号：US13413999

申请日：2012-03-07

申请人： Timothy Geary

发明人： Timothy Geary

IPC分类号： E01C3/06

CPC分类号： E01C5/12 ,  E01C11/005 ,  E01C23/06

摘要： A road patch for repair of potholes is disclosed. A pothole is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, a road patch is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The road patch forms a water proof seal over the surface area of the patch preventing water from seeping into the repaired pothole. The patch also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill.

摘要翻译： 公开了修补坑洼的道路补丁。 用沥青填充物预先修复坑洞，并按照当前的标准做法进行压实。 此后，将道路贴片放置在沥青填充物的压实顶表面上，重叠在相邻路面上并压缩。 道路贴片在贴剂的表面积上形成防水密封，防止水渗入修复的坑洞中。 该贴片还抵抗裂纹扩展，并最大限度地减少沥青切屑的可能性和沥青填料的破裂。

公开(公告)号：US08722332B2

公开(公告)日：2014-05-13

申请号：US13638799

申请日：2011-03-30

申请人： Roger Prichard ,  Catherine Bourguinat ,  Timothy Geary ,  Rudolf Schenker

发明人： Roger Prichard ,  Catherine Bourguinat ,  Timothy Geary ,  Rudolf Schenker

IPC分类号： A61K31/495

CPC分类号： C12Q1/6888 ,  A61K31/495 ,  A61K31/555 ,  C07K14/4354 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 11, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 11, or at positions corresponding to positions 11 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.

摘要翻译： 本发明涉及一种用于确定Dirofilaria spp的响应性的方法。 通过确定对应于SEQ ID NO：1中位置11的任何位置的线虫的P-糖蛋白基因的位置处的线虫的基因型，并且任选地位于SEQ ID NO：1中的位置618，其中在位置上的基因型GG 对应于位置11或在对应于SEQ ID NO：1中的位置11和618的位置表示线虫可能耐大环内酯。 本发明还涉及用于选择治疗感染大环内酯抗性Dirofilaria spp线虫的动物和治疗动物的方法; 或用于选择预防动物以防止大环内酯抗性Dirofilaria spp线虫感染，并向动物提供预防性。 本发明还涉及与SEQ ID NO：1具有至少80％序列同一性的分离的核酸。

公开(公告)号：US20130137669A1

公开(公告)日：2013-05-30

申请号：US13638799

申请日：2011-03-30

申请人： Roger Prichard ,  Catherine Bourguinat ,  Timothy Geary ,  Rudolf Schenker

发明人： Roger Prichard ,  Catherine Bourguinat ,  Timothy Geary ,  Rudolf Schenker

IPC分类号： A01N43/22 ,  A61K31/495 ,  A61K31/555 ,  C12Q1/68

CPC分类号： C12Q1/6888 ,  A61K31/495 ,  A61K31/555 ,  C07K14/4354 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 1 1, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 1 1, or at positions corresponding to positions 1 1 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.

摘要翻译： 本发明涉及一种用于确定Dirofilaria spp的响应性的方法。 通过确定对应于SEQ ID NO：1中位置11和任选地位置618的线虫的P-糖蛋白基因中的位置处的线虫的基因型，其中在一个大肠杆菌中的基因型GG 对应于位置11的位置或与SEQ ID NO：1中的位置11和618相应的位置表示线虫可能耐大环内酯。 本发明还涉及用于选择治疗感染大环内酯抗性Dirofilaria spp线虫的动物和治疗动物的方法; 或用于选择预防动物以防止大环内酯抗性Dirofilaria spp线虫感染，并向动物提供预防性。 本发明还涉及与SEQ ID NO：1具有至少80％序列同一性的分离的核酸。