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    Endothelial monocyte activating polypeptide II: a mediator which activates host response
    2.
    发明授权
    Endothelial monocyte activating polypeptide II: a mediator which activates host response 失效
    内皮单核细胞激活多肽II：激活宿主反应的介质

    公开(公告)号：US06734168B2

    公开(公告)日：2004-05-11

    申请号：US09851026

    申请日：2001-05-07

    申请人： David M. Stern ,  Matthias Clauss ,  Janet Kao ,  Mark Kayton ,  Steven K. Libutti

    发明人： David M. Stern ,  Matthias Clauss ,  Janet Kao ,  Mark Kayton ,  Steven K. Libutti

    IPC分类号： A61K3800

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/52

    摘要： The present invention provides for a purified endothelial monocyte activating polypeptide II, wherein the polypeptide has an apparent molecular weight of about 20,000 Daltons. The present invention also provides for an effector cell activating protein comprising a polypeptide having an amino acid sequence wherein at least four amino acid residues are the same as RIGRTVT and are in the same relative positions. The invention also provides for a DNA which encodes the effector cell activating protein. The invention also provides for methods of inducing inflammation in a subject and methods of treating tumors in a subject. The invention also provides for a pharmaceutical composition which comprises the endothelial monocyte activating polypeptide II and a carrier.

    摘要翻译： 本发明提供纯化的内皮单核细胞活化多肽II，其中所述多肽具有约20,000道尔顿的表观分子量。 本发明还提供了一种效应细胞活化蛋白，其包含具有氨基酸序列的多肽，其中至少四个氨基酸残基与RIGRTVT相同并且处于相同的相对位置。 本发明还提供编码效应细胞活化蛋白的DNA。 本发明还提供了在受试者中诱导炎症的方法和治疗受试者肿瘤的方法。 本发明还提供了包含内皮单核细胞活化多肽II和载体的药物组合物。

    Endothelial monocyte activating polypeptide II: a mediator which activates host response
    3.
    发明授权
    Endothelial monocyte activating polypeptide II: a mediator which activates host response 失效
    内皮单核细胞激活多肽II：激活宿主反应的介质

    公开(公告)号：US06228837B1

    公开(公告)日：2001-05-08

    申请号：US08360821

    申请日：1996-10-08

    申请人： David M. Stern ,  Matthias Clauss ,  Janet Kao ,  Mark Kayton ,  Steven K. Libutti

    发明人： David M. Stern ,  Matthias Clauss ,  Janet Kao ,  Mark Kayton ,  Steven K. Libutti

    IPC分类号： A61K3800

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/52

    摘要： This invention provides a purified endothelial monocyte activating polypeptide (EMAP II). It further provides a method of obtaining purified endothelial monocyte activating polypeptide (EMAP II), a method of making antibodies to it and a method of detecting it. This invention also provides an effector cell activating protein which contains an amino acid sequence homologous to RIGRIVT and a method of detecting same. This invention also provides a method of treating a tumor in a subject by administering an effective dose of endothelial monocyte activating polypeptide (EMAP II).

    摘要翻译： 本发明提供纯化的内皮单核细胞活化多肽（EMAP II）。 它进一步提供了获得纯化的内皮单核细胞活化多肽（EMAP II）的方法，一种制备抗体的方法及其检测方法。 本发明还提供了含有与RIGRIVT同源的氨基酸序列的效应细胞活化蛋白及其检测方法。 本发明还提供了通过施用有效剂量的内皮单核细胞活化多肽（EMAP II）来治疗受试者的肿瘤的方法。

    Quantitative assay of the angiogenic and antiangiogenic activity of a test molecule
    4.
    发明申请
    Quantitative assay of the angiogenic and antiangiogenic activity of a test molecule 审中-公开
    测试分子的血管生成和抗血管生成活性的定量测定

    公开(公告)号：US20050175980A1

    公开(公告)日：2005-08-11

    申请号：US10510652

    申请日：2003-04-09

    申请人： Steven Libutti ,  Mark Kayton

    发明人： Steven Libutti ,  Mark Kayton

    IPC分类号： A61K49/00 ,  C12Q1/00

    CPC分类号： A61K49/0008

    摘要： A method of measuring the angiogenic or antiangiogenic activity of a test molecule comprising (i) utilizing a modified CAM assay to assign an FVD value for a test region of interest and comparing this value to an FVD value for a control region of interest, or (ii) utilizing a modified CAM assay to determine the spectrophotometric absorbance value of a test region of interest and comparing this value to the spectrophotometric absorbance value of a control region of interest, wherein a lower value of the test region of interest as compared to the of the control region of interest is indicative of the test molecule being useful as an inhibitor of angiogenesis, and wherein a higher value of the test region of interest as compared to the value of the control region of interest is indicative of the test molecule being useful as a stimulator of angiogenesis.

    摘要翻译： 一种测量测试分子的血管生成或抗血管生成活性的方法，包括（i）利用修饰的CAM测定法为感兴趣的测试区域分配FVD值，并将该值与感兴趣的对照区域的FVD值进行比较，或（ ii）利用修饰的CAM测定法来确定感兴趣的测试区域的分光光度吸光度值，并将该值与感兴趣的对照区域的分光光度吸光度值进行比较，其中所测试的测试区域的值与 所述对照区域指示所述测试分子可用作血管生成抑制剂，并且其中所述测试区域的值与所述对照区域的值相比指示所述测试分子可用作 血管生成的刺激剂。

    Quantitative assay of the angiogenic and antiangiogenic activity of a test molecule
    5.
    发明申请
    Quantitative assay of the angiogenic and antiangiogenic activity of a test molecule 审中-公开
    测试分子的血管生成和抗血管生成活性的定量测定

    公开(公告)号：US20050136006A1

    公开(公告)日：2005-06-23

    申请号：US11014472

    申请日：2004-12-16

    申请人： Steven Libutti ,  Mark Kayton

    发明人： Steven Libutti ,  Mark Kayton

    IPC分类号： A61K49/00 ,  C12Q1/00 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00 ,  G06K9/00

    CPC分类号： A61K49/0008

    摘要： A method of measuring the angiogenic or antiangiogenic activity of a test molecule comprising (i) utilizing a modified CAM assay to assign an FVD value for a test region of interest and comparing this value to an FVD value for a control region of interest, or (ii) utilizing a modified CAM assay to determine the spectrophotometric absorbance value of a test region of interest and comparing this value to the spectrophotometric absorbance value of a control region of interest, wherein a lower value of the test region of interest as compared to the of the control region of interest is indicative of the test molecule being useful as an inhibitor of angiogenesis, and wherein a higher value of the test region of interest as compared to the value of the control region of interest is indicative of the test molecule being useful as a stimulator of angiogenesis. Furthermore, such measurements of angiogenic or antiangiogenic activity may be monitored in an animal or patient afflicted with a disease.

    摘要翻译： 一种测量测试分子的血管生成或抗血管生成活性的方法，包括（i）利用修饰的CAM测定法为感兴趣的测试区域分配FVD值，并将该值与感兴趣的对照区域的FVD值进行比较，或（ ii）利用修饰的CAM测定法来确定感兴趣的测试区域的分光光度吸光度值，并将该值与感兴趣的对照区域的分光光度吸光度值进行比较，其中所测试的测试区域的值与 所述对照区域指示所述测试分子可用作血管生成抑制剂，并且其中所述测试区域的值与所述对照区域的值相比指示所述测试分子可用作 血管生成的刺激剂。 此外，可以在患有疾病的动物或患者中监测血管生成或抗血管生成活性的这种测量。