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公开(公告)号：US07285561B2
公开(公告)日：2007-10-23
申请号：US11486348
申请日：2006-07-13
IPC分类号： C07D471/04 , A61K31/4184 , A61K31/4188 , A61P19/02 , A61P25/28 , A61P11/00 , C07D487/04 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
摘要翻译： 本发明公开了对应于式I的化合物：其中A，Z，Z 1，Y，R 1和R 2定义如 说明书以及药物制剂，制备方法和用途。
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公开(公告)号：US07285559B2
公开(公告)日：2007-10-23
申请号：US11486193
申请日：2006-07-13
IPC分类号： C07D487/14 , A61K31/519 , A61P19/02 , A61P25/28
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
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公开(公告)号：US07081462B2
公开(公告)日：2006-07-25
申请号：US11122137
申请日：2005-05-04
IPC分类号： C07D487/14 , A61K31/519 , A61P19/02 , A61P25/28
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
摘要翻译： 本发明公开了对应于式I的化合物：其中A，Z，Z 1，Y，R 1和R 2定义如 说明书以及药物制剂，制备方法和用途。
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公开(公告)号：US06949560B2
公开(公告)日：2005-09-27
申请号：US10406364
申请日：2003-04-03
IPC分类号： A61P11/00 , A61P25/00 , A61P29/00 , C07D471/14 , C07D487/14 , A61K31/519 , A61P19/02 , A61P25/28
CPC分类号： C07D471/14 , C07D487/14
摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
摘要翻译： 本发明公开了对应于式I的化合物：其中A，Z，Z 1，Y，R 1和R 2定义如 说明书以及药物制剂，制备方法和用途。
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公开(公告)号：US06846828B2
公开(公告)日：2005-01-25
申请号：US10288968
申请日：2002-11-06
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P1/04 , A61P3/10 , A61P17/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/505 , C07D239/32
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.
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公开(公告)号：US07157580B2
公开(公告)日：2007-01-02
申请号：US10967430
申请日：2004-10-18
IPC分类号： C07D401/12 , C07D401/04 , C07D403/04 , C07D403/12
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein
摘要翻译： 氨基嘧啶和氨基吡啶（I）化合物，用于治疗炎症，代谢或恶性疾病的组合物和方法在本文中提供
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公开(公告)号：US08846705B2
公开(公告)日：2014-09-30
申请号：US12963413
申请日：2010-12-08
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US08318719B2
公开(公告)日：2012-11-27
申请号：US12765904
申请日：2010-04-23
IPC分类号： C07D403/14 , C07D413/04 , A61K31/5513 , A61K31/553 , A61P29/00
CPC分类号： C07D413/14 , C07D403/14
摘要： This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-II: wherein, variables Q1, Q2, R, X, Y1, Y2, Y2′, Y3, Y4, Y5, m, and p are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-II and at least one carrier, diluent or excipient.
摘要翻译： 本申请公开了根据通式I-II的5-苯基-1H-吡啶-2-酮，6-苯基-2H-哒嗪-3-酮和5-苯基-1H-吡嗪-2-酮衍生物：其中， 变量Q1，Q2，R，X，Y1，Y2，Y2'，Y3，Y4，Y5，m和p如本文所述限定Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I-II化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：US20120230951A1
公开(公告)日：2012-09-13
申请号：US13414854
申请日：2012-03-08
申请人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
发明人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
IPC分类号： A61K31/55 , A61P37/02 , A61P31/14 , A61K38/21 , C07D487/06 , A61K31/551
CPC分类号： C07D487/06 , A61K31/55 , A61K31/551 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本发明提供用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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10.发明授权公开(公告)号：US08193368B2
公开(公告)日：2012-06-05
申请号：US12583325
申请日：2009-08-18
IPC分类号： C07D257/04
CPC分类号： A61K31/41 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D241/12 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/08
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中R 1为任选取代的四唑基，R 2为任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，R 3，R 4，R 5和R 6如本文所定义。 还提供了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。
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