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8 条记录 (耗时 0.029 秒)

    Mismatch repair detection
    1.
    发明授权
    Mismatch repair detection 失效

    公开(公告)号：US06406847B1

    公开(公告)日：2002-06-18

    申请号：US09271055

    申请日：1999-03-17

    申请人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

    发明人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156

    摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

    Mismatch repair detection
    3.
    发明授权
    Mismatch repair detection 失效
    不匹配修复检测

    公开(公告)号：US06709827B2

    公开(公告)日：2004-03-23

    申请号：US10072047

    申请日：2002-02-08

    申请人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

    发明人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156

    摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

    摘要翻译： 用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。 将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。 得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。 此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

    Mismatch repair detection
    4.
    发明申请
    Mismatch repair detection 审中-公开
    不匹配修复检测

    公开(公告)号：US20050239080A1

    公开(公告)日：2005-10-27

    申请号：US10728122

    申请日：2003-12-03

    申请人： David Cox ,  Malek Faham ,  Siamak Baharloo

    发明人： David Cox ,  Malek Faham ,  Siamak Baharloo

    IPC分类号： C12N1/21 ,  C12N15/74 ,  C12Q1/68

    CPC分类号： C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156

    摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

    摘要翻译： 用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。 将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。 得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。 此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

    E-COMMERCE SYSTEMS AND METHODS
    6.
    发明申请
    E-COMMERCE SYSTEMS AND METHODS 审中-公开
    电子商务系统和方法

    公开(公告)号：US20070203747A1

    公开(公告)日：2007-08-30

    申请号：US11567726

    申请日：2006-12-06

    申请人： Siamak Baharloo ,  James Gilmore ,  Michael Stapleton ,  Anthony Stevens ,  Martin Naley ,  Nicole Brockway

    发明人： Siamak Baharloo ,  James Gilmore ,  Michael Stapleton ,  Anthony Stevens ,  Martin Naley ,  Nicole Brockway

    IPC分类号： G06Q50/00 ,  G06Q10/00 ,  C12Q1/00

    CPC分类号： G06Q30/00 ,  G06Q50/22 ,  Y02A90/22

    摘要： The invention is in general directed to methods and processes for generating revenue via an electronic commerce website. The invention is also directed to methods of processing product orders and selling product related to protocols, workflows, or other applications. The invention also contemplates methods for selling products, which include previously ordered products, related products, substitute products, and equivalent products, including but not limited to equivalent protocol products, matched reagent sets, kits, and biomodules for practicing said protocols and equivalent protocols.

    摘要翻译： 本发明一般涉及通过电子商务网站产生收入的方法和过程。 本发明还涉及处理产品订单并销售与协议，工作流程或其他应用相关的产品的方法。 本发明还考虑了销售产品的方法，包括先前订购的产品，相关产品，替代产品和等同产品，包括但不限于等效的协议产品，匹配的试剂盒，试剂盒和用于实施所述协议和等效协议的生物模块。