公开(公告)号：US4374770A

公开(公告)日：1983-02-22

申请号：US309664

申请日：1981-10-08

Applicant: John A. Hyatt ,  David S. Kashdan

Inventor： John A. Hyatt ,  David S. Kashdan

IPC: C07C51/58 ,  C07C107/06

CPC classification number: C07C51/58

Abstract: Disclosed is a process for converting aromatic aldehydes to the corresponding acid chlorides by reacting an aromatic aldehyde with sulfuryl chloride in the presence of a catalytic amount of a phosphine, phosphine oxide or phosphonium compound. The product compounds produced by the process of this invention are useful as chemical synthesis intermediates in the preparation of pharmaceuticals, dyes, herbicides and photographic chemicals.

Abstract translation: 公开了通过在催化量的膦，氧化膦或鏻化合物的存在下使芳族醛与磺酰氯反应来将芳族醛转化成相应的酰氯的方法。 通过本发明方法生产的产品化合物可用作制备药物，染料，除草剂和照相化学品的化学合成中间体。

公开(公告)号：US5182379A

公开(公告)日：1993-01-26

申请号：US533319

申请日：1990-06-05

Applicant: Phillip M. Cook ,  David S. Kashdan

Inventor： Phillip M. Cook ,  David S. Kashdan

IPC: C08B3/22 ,  C08B13/00 ,  C08G81/00 ,  C09D101/32

CPC classification number: C09D101/32 ,  C08B13/00 ,  C08B3/22 ,  C08G81/00 ,  Y10T428/31634 ,  Y10T428/31703 ,  Y10T428/3179 ,  Y10T428/3188

Abstract: Modified cellulose esters are described that are prepared by grafting melamine moieties onto the backbone of cellulose esters. The resulting materials are useful in coating applications for wood, leather, and metal substrates and yield highly solvent-resistant coatings with enhanced properties when heated in the presence of an acid catalyst.

Abstract translation: 描述了通过将三聚氰胺部分接枝到纤维素酯的主链上制备的改性纤维素酯。 所得材料可用于木材，皮革和金属基材的涂布应用中，并在酸催化剂存在下加热时产生具有增强性能的高耐溶剂性涂料。

公开(公告)号：US4795641A

公开(公告)日：1989-01-03

申请号：US087566

申请日：1987-08-20

Applicant: David S. Kashdan

Inventor： David S. Kashdan

IPC: C08L1/10 ,  A01N25/10 ,  A61K9/20 ,  A61K9/26 ,  A61K9/70 ,  A61K47/00 ,  A61K47/38 ,  C08K5/00 ,  C08L1/00 ,  C08L1/14 ,  D01F2/28 ,  C08L1/08

CPC classification number: A61K9/7007 ,  A01N25/10 ,  A61K9/2054 ,  C08L1/14

Abstract: Disclosed are polymer blends containing a minor amount of cellulose acetate and a major amount of cellulose acetate phthalate, cellulose acetate trimellitate or cellulose acetate succinate. The blends have reverse phase morphology, that is, the minor component forms a continuous phase. The blends are useful for zero-order controlled delivery of bioactive agents such as pharmaceutical and agricultural chemicals.

公开(公告)号：US5356634A

公开(公告)日：1994-10-18

申请号：US975758

申请日：1992-11-13

Applicant: Stephen H. Wu ,  Carol J. Greene ,  Shane K. Kirk ,  David S. Kashdan

Inventor： Stephen H. Wu ,  Carol J. Greene ,  Shane K. Kirk ,  David S. Kashdan

IPC: A23K1/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K9/20

CPC classification number: A61K9/5042 ,  A23K40/35 ,  A61K9/2866

Abstract: Provided is a controlled-release system for delivery of bioactive materials such as medicaments, cosmetic ingredients and agrichemicals using cellulose acetate succinate or certain blends of cellulose acetate phthalate polymers as enteric coating materials. Also provided is a method for delivering active ingredients to animals utilizing the controlled-release system of the invention.

Abstract translation: 提供了一种用于递送生物活性材料如药物，化妆品成分和农用化学品的控释系统，其使用醋酸琥珀酸乙酯或某些醋酸纤维素邻苯二甲酸酯聚合物的混合物作为肠溶衣材料。 还提供了使用本发明的控制释放系统将活性成分递送到动物的方法。

公开(公告)号：US4496762A

公开(公告)日：1985-01-29

申请号：US480039

申请日：1983-03-29

Applicant: David S. Kashdan

Inventor： David S. Kashdan

IPC: C07C231/14 ,  C07C235/34 ,  C07C103/76 ,  C07C102/08

CPC classification number: C07C231/14 ,  C07C2101/16

Abstract: An improved method for preparing a compound having the formula ##STR1## which is an intermediate in the preparation of dextromethorphan, the improved method comprises the steps of(A) hydrogenating a compound having the formula ##STR2## in the presence of a hydrogenation catalyst to obtain a compound having the formula ##STR3## (B) hydrogenating the product of Step (A) in the presence of a hydrogen treated rhodium catalyst to obtain a compound having the formula ##STR4## (C) reacting the product of Step (B) with 4-methoxyphenylacetic acid to obtain a mixture of compounds comprising ##STR5## (D) dehydrating the product mixture of Step (C).

Abstract translation: 改进的方法包括以下步骤：（A）在氢化催化剂存在下氢化具有式“IMAGE”的化合物， 得到具有式（A）的化合物（B）在氢处理的铑催化剂的存在下氢化步骤（A）的产物，得到具有下式的化合物：（C）使步骤（B）的产物 与4-甲氧基苯基乙酸反应，得到包含（D）步骤（C）的产物混合物脱水的化合物的混合物。