公开(公告)号：US20110212529A1

公开(公告)日：2011-09-01

申请号：US11716899

申请日：2007-03-12

申请人： David Souza ,  Donna Armentano

发明人： David Souza ,  Donna Armentano

IPC分类号： C12N15/85 ,  C07H21/04 ,  C12N1/00 ,  C12N5/10

CPC分类号： C12N15/85 ,  C12N2830/008 ,  C12N2830/85

摘要： The invention is directed to novel combinations of muscle-specific enhancers and promoter elements useful for achieving persistent expression in the muscle or myocyctes. The muscle-specific promoter elements are derived from a muscle creatine kinase promoter, a troponin I promoter, a skeletal alpha-actin promoter, or a desmin promoter. The muscle-specific enhancer elements are derived from either troponin I internal regulatory elements, muscle creatine kinase enhancers, or desmin enhancers.

摘要翻译： 本发明涉及用于在肌肉或肌细胞中实现持续表达的肌肉特异性增强子和启动子元件的新颖组合。 肌肉特异性启动子元件来源于肌肉肌酸激酶启动子，肌钙蛋白I启动子，骨骼α-肌动蛋白启动子或结蛋白启动子。 肌肉特异性增强子元件来自肌钙蛋白I内调节元件，肌肉肌酸激酶增强子或结蛋白增强子。

公开(公告)号：US20140310591A1

公开(公告)日：2014-10-16

申请号：US14209824

申请日：2014-03-13

申请人： Thong Nguyen ,  Jay Finch ,  Erik Mason ,  Erik Mitchell ,  Cory Roloff ,  Nathaniel Caza ,  David Souza ,  Ryan Schmidt ,  Chrystine Twigg ,  Sean Walker

发明人： Thong Nguyen ,  Jay Finch ,  Erik Mason ,  Erik Mitchell ,  Cory Roloff ,  Nathaniel Caza ,  David Souza ,  Ryan Schmidt ,  Chrystine Twigg ,  Sean Walker

IPC分类号： G06F17/22

CPC分类号： G06F17/2247 ,  G06F17/24

摘要： Systems and methods for designing and implementing dynamic and template-based web page content are described herein. One example includes a presentation layer software development kit providing a full-featured graphical user interface for the design of web page components and structures. The presentation layer software development kit may integrate with various design, development, compilation, and testing tools to generate production-ready web page output in a scalable architecture. Using the presentation layer software development kit, modifications to the web page content may be generated, tested, and deployed in a real-time basis, reducing design and implementation times.