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公开(公告)号：US5589196A
公开(公告)日：1996-12-31
申请号：US252376
申请日：1994-06-01
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61K33/24 , A61Q15/00 , C01F7/00 , C01G1/06 , C01G25/04 , C07F9/00 , A61K7/32 , C01G25/00
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/44 , Y10S424/05
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromatography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
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公开(公告)号：US4775528A
公开(公告)日：1988-10-04
申请号：US036262
申请日：1987-04-09
CPC分类号： A61K8/44 , A61K8/26 , A61K8/28 , A61Q15/00 , Y10S424/05
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromotography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
摘要翻译： 通过在至少含有至少含有组合物的氢氧化铝组分的2-20重量％的水溶液中加热至少含有氯化氢氧化铝的组合物来制备具有稳定固体形式的稳定固体形式的羟基氧化锆和氢氧化铝的组合物，其具有改善的止汗效力 直到在交联葡聚糖上通过凝胶渗透色谱法测量的Kd = 0.7处的峰4的高度与K 3的峰3的比例至少为2:1，然后将溶液快速 干燥至固体形式。
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公开(公告)号：US5486347A
公开(公告)日：1996-01-23
申请号：US452554
申请日：1995-05-25
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61K33/24 , A61Q15/00 , C01F7/00 , C01G1/06 , C01G25/04 , C07F9/00 , A61K7/34 , A61K7/38 , C01G9/02
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/44 , Y10S424/05
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromatography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
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公开(公告)号：US5298640A
公开(公告)日：1994-03-29
申请号：US939808
申请日：1992-09-03
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61K33/24 , A61Q15/00 , C01F7/00 , C01G25/04 , C07F9/00 , A61K7/34 , A61K7/38 , B01D11/00
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromatography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
摘要翻译： 通过在至少含有至少含有组合物的氢氧化铝组分的2-20重量％的水溶液中加热至少含有氯化氢氧化铝的组合物来制备具有稳定固体形式的稳定固体形式的羟基氧化锆和氢氧化铝的组合物，其具有改善的止汗效力 直到在交联葡聚糖上通过凝胶渗透色谱法测定的Kd = 0.7时的峰4的高度与K 3的峰3的比例至少为2:1，然后使溶液迅速 干燥至固体形式。
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公开(公告)号：US5770186A
公开(公告)日：1998-06-23
申请号：US771364
申请日：1996-12-16
IPC分类号： A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61K33/24 , A61Q15/00 , C01F7/00 , C01G1/06 , C01G25/04 , C07F9/00 , A61K7/32 , C01G25/00
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/44 , Y10S424/05
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromatography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
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公开(公告)号：US5114705A
公开(公告)日：1992-05-19
申请号：US287096
申请日：1988-12-20
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/44 , Y10S424/05 , Y10S514/938
摘要： A composition of zirconyl hydroxy chloride and aluminum chlorhydroxide in stable solid form having improved antiperspirant efficacy when dissolved in water is made by heating a 2-20% by weight aqueous solution containing at least the aluminum chlorhydroxide component of the composition at a temperature of at least 50.degree. C. until the ratio of the height of peak 4 at Kd=0.7 to that of peak 3 at Kd=0.5 as measured by gel permeation chromatography on cross-linked dextran is at least 2:1, then subjecting the solution to rapid drying to solid form.
摘要翻译： 通过在至少含有至少含有组合物的氢氧化铝组分的2-20重量％的水溶液中加热至少含有氯化氢氧化铝的组合物来制备具有稳定固体形式的稳定固体形式的羟基氧化锆和氢氧化铝的组合物，其具有改善的止汗效力 直到在交联葡聚糖上通过凝胶渗透色谱法测定的Kd = 0.7时峰4的高度与K 3 = 3的峰3的比例至少为2:1，然后使溶液快速 干燥至固体形式。
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公开(公告)号：US06632420B1
公开(公告)日：2003-10-14
申请号：US09672350
申请日：2000-09-28
申请人： Raymond W. Cen , David T. Callaghan
发明人： Raymond W. Cen , David T. Callaghan
IPC分类号： A61K732
摘要： A clear personal care composition includes water, a volatile silicone, and a silicone polyether having a molecular weight greater than 1000 and an HLB greater than 4. The composition may be, for example, an antiperspirant or deodorant composition.
摘要翻译： 清洁的个人护理组合物包括水，挥发性硅氧烷和分子量大于1000且HLB大于4的硅氧烷聚醚。组合物可以是例如止汗剂或除臭剂组合物。
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公开(公告)号：US5368842A
公开(公告)日：1994-11-29
申请号：US968552
申请日：1992-10-29
摘要： The present invention embraces an aerosol antiperspirant composition which comprises a suspension of about 5 to 15% high efficacy aluminum salt in powder form in about 15 to 35% volatile silicone and about 40 to 80% liquefied hydrocarbon propellant with about 0.7 to 1.5% hydrophobic colloidal silica suspending agent and about 0.15 to 0.35% hydrophilic colloidal silica suspending agent. The composition of the present invention has superior antiperspirant efficacy and avoids the use of materials which have an adverse effect on efficacy, namely oil soluble emollient esters such as isopropyl myristate and polar agents such as ethanol.
摘要翻译： 本发明包括一种气溶胶止汗组合物，其包含约15至15％的粉末形式的约5至15％的高效率铝盐在约15至35％挥发性硅氧烷中的悬浮液和约40至80％液化烃推进剂，其中约0.7至1.5％的疏水性胶体 二氧化硅悬浮剂和约0.15至0.35％亲水胶体二氧化硅悬浮剂。 本发明的组合物具有优异的止汗功效，避免使用对功效不利的材料，即油溶性软化酯如肉豆蔻酸异丙酯和极性试剂如乙醇。
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