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    Systems and methods for delivery of drugs
    1.
    发明申请
    Systems and methods for delivery of drugs 审中-公开
    用于输送药物的系统和方法

    公开(公告)号：US20090263346A1

    公开(公告)日：2009-10-22

    申请号：US12315876

    申请日：2008-12-04

    申请人： David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra Ottensmann

    发明人： David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra Ottensmann

    IPC分类号： A61K47/48 ,  A61P25/18

    CPC分类号： A61K9/146 ,  A61K9/0019 ,  A61K9/0024

    摘要： Systems and methods for delivering drugs. Crystalline polymeric systems, referred to as CYC carriers, are associated with the drugs, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.

    摘要翻译： 递送药物的系统和方法。 称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与药物相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 另一类的CYC载体是非聚合物。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 CYC载体优选是可生物侵蚀的。

    SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS
    10.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 有权
    用于输送材料的系统和方法

    公开(公告)号：US20110009571A1

    公开(公告)日：2011-01-13

    申请号：US12746178

    申请日：2008-12-03

    申请人： David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra N. Ottensmann ,  Natarajan Balachander

    发明人： David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra N. Ottensmann ,  Natarajan Balachander

    IPC分类号： C08G63/06

    CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K9/146

    摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.

    摘要翻译： 用于输送释放材料的系统和方法，例如药物和其他生物活性材料。 称为CYC载体的结晶聚合物体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 对于一些用途，特别是药物的递送，优选使用生物侵蚀性CYC载体。