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    Antibodies against nogo receptor
    1.
    发明授权
    Antibodies against nogo receptor 有权
    针对nogo受体的抗体

    公开(公告)号：US07973139B2

    公开(公告)日：2011-07-05

    申请号：US11090847

    申请日：2005-03-25

    Applicant: Adam Bell ,  Craig A. Rosen

    Inventor： Adam Bell ,  Craig A. Rosen

    IPC: C07K16/00 ,  C07K14/00 ,  C12N15/85 ,  C12N5/12 ,  A61K39/395

    CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    Abstract: The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

    Abstract translation: 本发明涉及特异性结合Nogo受体（NogoR）的抗体和相关分子。 这样的抗体具有例如用于治疗脊髓损伤，脑损伤，麻痹，退行性神经系统疾病和中风的用途。 本发明还涉及编码抗NogoR抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

    Systems and methods for delivery of drugs
    3.
    发明申请
    Systems and methods for delivery of drugs 审中-公开
    用于输送药物的系统和方法

    公开(公告)号：US20090263346A1

    公开(公告)日：2009-10-22

    申请号：US12315876

    申请日：2008-12-04

    Applicant: David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra Ottensmann

    Inventor： David Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra Ottensmann

    IPC: A61K47/48 ,  A61P25/18

    CPC classification number: A61K9/146 ,  A61K9/0019 ,  A61K9/0024

    Abstract: Systems and methods for delivering drugs. Crystalline polymeric systems, referred to as CYC carriers, are associated with the drugs, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.

    Abstract translation: 递送药物的系统和方法。 称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与药物相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 另一类的CYC载体是非聚合物。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 CYC载体优选是可生物侵蚀的。

    Colon Specific Gene and Protein and Cancer
    6.
    发明申请
    Colon Specific Gene and Protein and Cancer 审中-公开
    结肠特异性基因和蛋白质和癌症

    公开(公告)号：US20070178108A1

    公开(公告)日：2007-08-02

    申请号：US11696199

    申请日：2007-04-04

    Applicant: Patrick Dillon ,  Yi Li ,  Daniel Soppet ,  Adam Bell ,  D. Duan ,  Ralph Alderson ,  Wendy Halpern

    Inventor： Patrick Dillon ,  Yi Li ,  Daniel Soppet ,  Adam Bell ,  D. Duan ,  Ralph Alderson ,  Wendy Halpern

    IPC: A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

    CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57419

    Abstract: Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.

    Abstract translation: 公开了人结肠特异性多核苷酸（DNA和RNA），多肽和抗体，以及使用和产生这种多核苷酸，多肽和抗体的方法。 更具体地，公开了利用这些多核苷酸，多肽和抗体检测，诊断，预防，治疗和/或改善癌症（特别是胃肠道癌症如结肠癌和胰腺癌）的方法。 还公开了通过结肠特异性蛋白质和/或通过结肠特异性蛋白质受体靶向和破坏癌细胞（特别是胃肠道癌症例如结肠和胰腺癌）的组合物和方法。 此外，还公开了筛选结肠特异性蛋白质的拮抗剂和结合配偶体的方法以及这些拮抗剂和结合配偶体的治疗用途。

    Systems and methods for delivery of materials
    7.
    发明授权
    Systems and methods for delivery of materials 有权
    材料交付的系统和方法

    公开(公告)号：US08524259B2

    公开(公告)日：2013-09-03

    申请号：US12746178

    申请日：2008-12-03

    Applicant: David D. Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra N. Ottensmann ,  Natarajan Balachander

    Inventor： David D. Taft ,  Steven Bitler ,  Qiang Zheng ,  Stelios Tzannis ,  Adam Bell ,  Wei-Guo Dai ,  Sandra N. Ottensmann ,  Natarajan Balachander

    IPC: C08G63/06

    CPC classification number: A61K9/0024 ,  A61K9/0019 ,  A61K9/146

    Abstract: Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.

    Abstract translation: 用于输送释放材料的系统和方法，例如药物和其他生物活性材料。 称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 对于一些用途，特别是药物的递送，优选使用生物侵蚀性CYC载体。

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