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    Methods and compositions for diagnosis of ectopic pregnancy
    1.
    发明授权
    Methods and compositions for diagnosis of ectopic pregnancy 有权
    用于诊断异位妊娠的方法和组成

    公开(公告)号：US09568486B2

    公开(公告)日：2017-02-14

    申请号：US13397442

    申请日：2012-02-15

    申请人： David W Speicher ,  Kurt T. Barnhart ,  Lynn A. Beer

    发明人： David W Speicher ,  Kurt T. Barnhart ,  Lynn A. Beer

    IPC分类号： G01N33/76 ,  G01N33/68 ,  C07K14/705

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/76 ,  G01N2333/471 ,  G01N2333/70503 ,  G01N2560/00 ,  G01N2800/368 ,  G01N2800/60

    摘要： Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of ISM2, ADAM12, PST1, PSG7, PST11, PSG9, PSG2 and other genes identified therein, including combinations thereof. A selected gene, gene transcript or protein/peptide expression product, or profiles or signatures formed by combinations of same, detected in a biological fluid of a subject, enables comparison of the corresponding genes, proteins or profiles from that of a reference or control having a normal intrauterine pregnancy. Detection of characteristic changes in the gene profile or protein expression signature of the subject is correlated with a diagnosis of ectopic pregnancy. Various compositions for use in such diagnosis include PCR primer-probe sets or ligands, labeled or immobilized, which are capable of detecting the changes in expression or translation of these targets.

    摘要翻译： 提供了通过检测ISM2，ADAM12，PST1，PSG7，PST11，PSG9，PSG2和其中鉴定的其他基因（包括其组合）的表达变化来诊断哺乳动物受试者异位妊娠的方法和组合物。 在受试者的生物流体中检测到的选择的基因，基因转录物或蛋白质/肽表达产物或通过其组合形成的特征或特征可以与相应的基因，蛋白质或轮廓比较， 子宫内正常怀孕。 检测受试者的基因谱或蛋白质表达特征的特征变化与异位妊娠的诊断相关。 用于这种诊断的各种组合物包括能够检测这些靶标的表达或翻译变化的PCR引物 - 探针组或标记或固定的配体。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ECTOPIC PREGNANCY
    2.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ECTOPIC PREGNANCY 有权
    方法和组合物用于诊断胃肠疾病

    公开(公告)号：US20120214685A1

    公开(公告)日：2012-08-23

    申请号：US13397442

    申请日：2012-02-15

    申请人： David W. Speicher ,  Kurt T. Barnhart ,  Lynn A. Beer

    发明人： David W. Speicher ,  Kurt T. Barnhart ,  Lynn A. Beer

    IPC分类号： C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C07K2/00 ,  G01N33/573 ,  C07K16/18 ,  G01N33/566 ,  C12Q1/68 ,  C40B30/10 ,  C07K16/40 ,  C07H21/00 ,  C07K14/00

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/76 ,  G01N2333/471 ,  G01N2333/70503 ,  G01N2560/00 ,  G01N2800/368 ,  G01N2800/60

    摘要： Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of ISM2, ADAM12, PST1, PSG7, PST11, PSG9, PSG2 and other genes identified therein, including combinations thereof. A selected gene, gene transcript or protein/peptide expression product, or profiles or signatures formed by combinations of same, detected in a biological fluid of a subject, enables comparison of the corresponding genes, proteins or profiles from that of a reference or control having a normal intrauterine pregnancy. Detection of characteristic changes in the gene profile or protein expression signature of the subject is correlated with a diagnosis of ectopic pregnancy. Various compositions for use in such diagnosis include PCR primer-probe sets or ligands, labeled or immobilized, which are capable of detecting the changes in expression or translation of these targets.

    摘要翻译： 提供了通过检测ISM2，ADAM12，PST1，PSG7，PST11，PSG9，PSG2和其中鉴定的其他基因（包括其组合）的表达变化来诊断哺乳动物受试者异位妊娠的方法和组合物。 在受试者的生物流体中检测到的选择的基因，基因转录物或蛋白质/肽表达产物或通过其组合形成的特征或特征可以与相应的基因，蛋白质或轮廓比较， 子宫内正常怀孕。 检测受试者的基因谱或蛋白质表达特征的特征变化与异位妊娠的诊断相关。 用于这种诊断的各种组合物包括能够检测这些靶标的表达或翻译变化的PCR引物 - 探针组或标记或固定的配体。

    Endometriosis markers
    4.
    发明授权
    Endometriosis markers 有权
    子宫内膜异位症

    公开(公告)号：US07943324B2

    公开(公告)日：2011-05-17

    申请号：US11643956

    申请日：2006-12-22

    申请人： Kurt T. Barnhart ,  Beata Seeber ,  George L. Gerton ,  Mary D. Sammel

    发明人： Kurt T. Barnhart ,  Beata Seeber ,  George L. Gerton ,  Mary D. Sammel

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2333/75 ,  G01N2800/368

    摘要： The present invention relates to methods for determining a risk or identifying a condition associated with the presence of endometriosis in a subject as well as testing a candidate compound for a therapeutic activity for the treatment of endometriosis and sorting patients based on the risk of having endometriosis. Specifically, the methods utilize novel markers for assessing the risk of the patient having endometriosis.

    摘要翻译： 本发明涉及用于确定与受试者中子宫内膜异位症存在相关的风险或鉴定病症的方法，以及基于患有子宫内膜异位症的风险来测试用于治疗子宫内膜异位症和分类患者的治疗活性的候选化合物。 具体来说，该方法利用新的标记物来评估患有子宫内膜异位症的患者的风险。