公开(公告)号：US20050090021A1

公开(公告)日：2005-04-28

申请号：US10398157

申请日：2001-10-09

申请人： David Walt ,  Shannon Stitzel

发明人： David Walt ,  Shannon Stitzel

IPC分类号： C40B60/14 ,  G01N21/77 ,  G01N33/543

CPC分类号： G01N21/7703 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00702 ,  C40B60/14

摘要： A micro-sphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

摘要翻译： 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的明显特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别每个传感器在随机色散中的传感器类型和位置 在传感器阵列中使用光学可询问编码方案的大量这种传感器。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US20080261323A1

公开(公告)日：2008-10-23

申请号：US12065667

申请日：2006-09-06

申请人： Dermot Diamond ,  Robert Byrne ,  Shannon Stitzel

发明人： Dermot Diamond ,  Robert Byrne ,  Shannon Stitzel

IPC分类号： G01N21/77

CPC分类号： G01N33/583 ,  G01N33/6839

摘要： Photochromic materials, such as spiropyran dyes, are disclosed that can be used for high-density optical storage and molecular switches. According to the disclosure these compounds can be used as transducers in optical sensors. When the spiropyran dye absorbs UV light it switches to the merocyanine form, and this structure has an active binding site for cations. When cations bind to the site, the resulting colored complex has a new absorption band in the visible spectrum. By shining white or green light on the colored complex, the dye is reverted to the closed spiropyran form, and the cation is released. The disclosure optimizes the immobilization of the spiropyran dye onto a polymer substrate via long chain alkyl groups. These long chain alkyl linkers enable the dye to reversibly form the preferred merocyanine (2):(1) cation sandwich complex.

摘要翻译： 公开了可用于高密度光学存储和分子开关的光致变色材料，例如螺吡喃染料。 根据公开内容，这些化合物可用作光学传感器中的换能器。 当吡咯啉染料吸收UV光时，它转变为部花青形式，并且该结构具有阳离子的活性结合位点。 当阳离子与该位点结合时，所得到的有色复合物在可见光谱中具有新的吸收带。 通过在有色复合物上照射白色或绿色光，染料被还原成封闭的螺吡喃形式，阳离子被释放。 本发明优化了通过长链烷基将螺吡喃染料固定在聚合物底物上。 这些长链烷基接头使得染料可逆地形成优选的部花青（2）：（1）阳离子三明治复合物。