利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.019 秒)

    Self-encoding sensor with microspheres
    3.
    发明申请
    Self-encoding sensor with microspheres 审中-公开
    具有微球的自编码传感器

    公开(公告)号：US20050090021A1

    公开(公告)日：2005-04-28

    申请号：US10398157

    申请日：2001-10-09

    申请人： David Walt ,  Shannon Stitzel

    发明人： David Walt ,  Shannon Stitzel

    IPC分类号： C40B60/14 ,  G01N21/77 ,  G01N33/543

    CPC分类号： G01N21/7703 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00702 ,  C40B60/14

    摘要： A micro-sphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    摘要翻译： 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的明显特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别每个传感器在随机色散中的传感器类型和位置 在传感器阵列中使用光学可询问编码方案的大量这种传感器。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

    CROSS-REACTIVE SENSORS
    5.
    发明申请
    CROSS-REACTIVE SENSORS 有权
    交叉传感器

    公开(公告)号：US20070122861A1

    公开(公告)日：2007-05-31

    申请号：US10221815

    申请日：2001-03-14

    申请人： David Walt ,  Caroline Schauer ,  Frank Steemers

    发明人： David Walt ,  Caroline Schauer ,  Frank Steemers

    IPC分类号： C12Q1/34 ,  C12Q1/37 ,  C12M3/00

    CPC分类号： C12Q1/44 ,  C12Q1/37

    摘要： The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.

    摘要翻译： 本发明提供了一种利用交叉反应识别元件的新型交叉反应传感器系统。 在本发明的系统中，所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用，由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个 的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂，由此分析所述可检测试剂，并且对所述信息进行处理以进行数据采集和解释。 在某些优选的实施方案中，直接检测可检测的试剂和/或变化，而在某些其它优选的实施方案中，可以借助于能够中继关于每个可产生的每个可检测试剂的信息的转导剂来检测可检测的试剂和/或变化 的所述物质的感兴趣的液体分析物，由此所述信息被处理用于数据采集和解释。 本发明还提供了用于分析分析物的方法，包括使一种或多种分析物与上述本发明的系统接触。

    Method and system of array imaging
    6.
    发明申请
    Method and system of array imaging 有权
    阵列成像的方法和系统

    公开(公告)号：US20070040095A1

    公开(公告)日：2007-02-22

    申请号：US11209432

    申请日：2005-08-22

    申请人： David Walt ,  Sandra Bencic-Nagale

    发明人： David Walt ,  Sandra Bencic-Nagale

    IPC分类号： G01J1/32 ,  H01J40/14

    CPC分类号： G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

    摘要： The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

    摘要翻译： 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并随时间增加强度以抵消光漂白的影响。

    Electro-optical stimulation/measurement
    7.
    发明申请
    Electro-optical stimulation/measurement 有权

    公开(公告)号：US20060013543A1

    公开(公告)日：2006-01-19

    申请号：US10503995

    申请日：2003-02-14

    申请人： David Walt ,  Sabine Szunerits

    发明人： David Walt ,  Sabine Szunerits

    IPC分类号： G02B6/44 ,  G02F1/295

    CPC分类号： G01D5/268 ,  A61B5/0071 ,  A61N1/08 ,  A61N1/205 ,  A61N5/0613 ,  A61N5/0622 ,  A61N2005/063 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/66

    摘要： An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

    Apparatus and method for cell migration assays
    8.
    发明申请
    Apparatus and method for cell migration assays 审中-公开
    用于细胞迁移测定的装置和方法

    公开(公告)号：US20080032324A1

    公开(公告)日：2008-02-07

    申请号：US11729431

    申请日：2007-03-28

    申请人： David Walt ,  Christopher Di Cesare

    发明人： David Walt ,  Christopher Di Cesare

    IPC分类号： C12N1/02 ,  C12M1/34

    CPC分类号： G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0065

    摘要： The present invention is directed to a method and apparatus for detecting and analyzing cell migration. More specifically, the present invention is directed to novel technology for analyzing cellular movement, including whole cell migration and subcellular component movement. Cells are distributed onto a substrate and monitored for migration or movement. According to one embodiment, when a labelled cell or portion of a cell passes over one of the delineations between detection units, such as individual fibers in a fiber optic bundle, the label causes a large intensity increase, which stays for a given “residence time” until the cell departs from the detection unit.

    摘要翻译： 本发明涉及一种用于检测和分析细胞迁移的方法和装置。 更具体地，本发明涉及用于分析细胞运动的新技术，包括全细胞迁移和亚细胞组分运动。 细胞分布在基质上并监测迁移或运动。 根据一个实施例，当标记的细胞或细胞的一部分经过诸如光纤束中的单个纤维的检测单元之间的描绘中的一个时，标签引起大的强度增加，其停留在给定的“停留时间 “直到细胞离开检测单元。

    Self-encoding sensor with microspheres
    10.
    发明申请
    Self-encoding sensor with microspheres 失效
    具有微球的自编码传感器

    公开(公告)号：US20050196317A1

    公开(公告)日：2005-09-08

    申请号：US11040504

    申请日：2005-01-21

    申请人： David Walt ,  Todd Dickinson

    发明人： David Walt ,  Todd Dickinson

    IPC分类号： C12M1/34 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/00 ,  G01N33/543 ,  G01N21/00

    CPC分类号： C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

    摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    摘要翻译： 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。